Results 11 to 20 of about 838,128 (221)

Detection of Metallo-beta-lactamase blaVIM-1 Gene in Clinical Isolates of Pseudomonas Aeruginosa in Mashhad

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2016
Introduction: Carbapenems are one of the latest drugs for treatment of threatening infections of Pseudomonas aeruginosa. Resistance to these antibiotics is sometimes caused by carbapnmase class B, such as VIM metallo-beta-lactamase (MBL) that is growing ...
M Nakhaei Moghaddam, M Hosseini Hasanabady   +1 more
doaj   +1 more source

Identification of São Paulo metallo-beta-lactamase-1-producing Pseudomonas aeruginosa in the Central-West region of Brazil: a case study

Revista da Sociedade Brasileira de Medicina Tropical
: Metallo-beta-lactamase production is an important mechanism for carbapenem resistance of Pseudomonas aeruginosa , which represents an emerging public health challenge.
Wirlaine Glauce Maciel, Kesia Esther da Silva, José Victor Bortolotto Bampi, Graciela Mendonça dos Santos Bet, Ana Carolina Ramos, Ana Cristina Gales, Simone Simionatto   +6 more
doaj   +2 more sources

Prevalence of metallo-β-lactamase-encoding genes among carbapenem-resistant Pseudomonas aeruginosa strains isolated from burn patients in Iran

Revista da Sociedade Brasileira de Medicina Tropical
Carbapenem-resistant Pseudomonas aeruginosa (CRPA) has been considered a major cause of infection and mortality in burn patients, especially in developing countries such as Iran. One of the most common mechanisms of carbapenem resistance is production of
Fereshteh Jabalameli, Elahe Taki, Mohammad Emaneini, Reza Beigverdi   +3 more
doaj   +2 more sources

Metallo Beta Lactamase Enzymes. [PDF]

Indian J Microbiol
Multidrug resistance has become more common in Gram-negative bacteria, making them one of the emerging public health problems with extremely detrimental effects on the world economy. These drugs are broad-spectrum-lactam antibiotics used as a last-resort treatment against multidrug-resistant microorganisms (MDROs).
Kareem SM, Hamzah IH, Ali MG.
europepmc   +3 more sources

Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates

, 2022
With the emergence and rapid spreading of NDM-1 and existence of clinically relevant VIM-1 and IMP-1, discovery of pan inhibitors targeting metallo-beta-lactamases (MBLs) became critical in our battle against bacterial infection.
Winnie Prosise (14231582), Shu-Wei Yang (2351068), Alex G. Therien (10156446), Weidong Pan (1427614), Giovanna Scapin (1427611), Christine Yang (149071), Li Xiao (307908), Jianping Pan (5473910), Amy Flattery (1349508), Thierry Fischmann (1586191), Alexander Pasternak (161010), Mihirbaran Mandal (2026381), Priya Dayananth (1720108), Todd W. Mayhood (2383978), Alexei V. Buevich (1433287), Katherine Young (526710), Jim Tata (1463734), Carrie Markgraf (14231588), Jacqueline D. Hicks (2335909), Nicholas Murgolo (1349487), Reynalda Keh de Jesus (14231579), Asra Mirza (1427602), Payal Sheth (3875491), Haifeng Tang (488592), Jin Wu (216487), Todd Black (1882981), Jing Su (23377), Yuriko Root (14231576), Rumin Zhang (2729599), Shuzhi Dong (2352922), Emma R. Parmee (298242), Haiqun Tang (2127373), Daniel F. Wyss (2177280), Inhou Chu (2026375), Charles Garlisi (4397194), Hai-Young Kim (156469), Lianzhu Liang (2276707), William K. Hagmann (1370268), Donald Chu (14231585), Artjohn Villafania (6917033), Guoqing Li (23674), Ronald Painter (2646250), Edward DiNunzio (12293994), Ann E. Weber (1416991)   +43 more
core   +2 more sources

Broad antibiotic resistance profile of the subclass B3 metallo-β-lactamase GOB-1, a di-zinc enzyme. [PDF]

, 2011
peer reviewedThe metallo-β-lactamase (MBL) GOB-1 was expressed via a T7 expression system in Escherichia coli BL21(DE3). The MBL was purified to homogeneity and shown to exhibit a broad substrate profile, hydrolyzing all the tested β-lactam compounds ...
Nathalie Selevsek, Carine Bebrone, Louise E. Horsfall, Lassaux, Patricia, Benoit M. R. Liénard, Kurt M. Hoffmann, Hoffmann, Kurt, Poirel, Laurent, Michael B. Kupper, Horsfall, Louise E., Horsfall, Louise E.; id_orcid, Bebrone, Carine, Izougarhane, Youssef, Jean-Marie Frère, Lienard, Benoit M. R., Youssef Izougarhane, Selevsek, Nathalie, Kupper, Michael B., Patricia Lassaux, Kupper, Michaël, Horsfall, Louise, Laurent Poirel, Liénard, Benoit, Galleni, Moreno, Frère, Jean-Marie, Hoffmann, Kurt M., Moreno Galleni   +26 more
core   +1 more source

One origin for metallo-β-lactamase activity, or two? An investigation assessing a diverse set of reconstructed ancestral sequences based on a sample of phylogenetic trees [PDF]

, 2014
This work was supported by BBSRC (grant BB/F016778/1)Bacteria use metallo-β-lactamase enzymes to hydrolyse lactam rings found in many antibiotics, rendering them ineffective.
Barker, Daniel, Rosanna G. Alderson, John B. O. Mitchell, Daniel Barker, Alderson, Rosanna Grace, Alderson, Rosanna G, Mitchell, John B O, Mitchell, John B. O., Mitchell, John B. O.; id_orcid   +8 more
core   +1 more source

Neutralizing Carbapenem Resistance by Co-Administering Meropenem with Novel β-Lactam-Metallo-β-Lactamase Inhibitors

Antibiotics, 2023
Virulent Enterobacterale strains expressing serine and metallo-β-lactamases (MBL) genes have emerged responsible for conferring resistance to hard-to-treat infectious diseases. One strategy that exists is to develop β-lactamase inhibitors to counter this
Nakita Reddy, Letisha Girdhari, Mbongeni Shungube, Arnoldus C. Gouws, Byron K. Peters, Kamal K. Rajbongshi, Sooraj Baijnath, Sipho Mdanda, Thandokuhle Ntombela, Thilona Arumugam, Linda A. Bester, Sanil D. Singh, Anil Chuturgoon, Per I. Arvidsson, Glenn E. M Maguire, Hendrik G. Kruger, Thavendran Govender, Tricia Naicker   +17 more
doaj   +1 more source

Extended spectrum and metalo beta-lactamase producing airborne Pseudomonas aeruginosa and Acinetobacter baumanii in restricted settings of a referral hospital: a neglected condition

Antimicrobial Resistance and Infection Control, 2017
Background Frequently encountered multidrug-resistant bacterial isolates of P. aeruginosa and A. baumannii are common and prevalent in a hospital environment.
Fithamlak Bisetegen Solomon, Fiseha Wadilo, Efrata Girma Tufa, Meseret Mitiku   +3 more
doaj   +1 more source

Metallo-β-Lactamase Inhibitor Phosphonamidate Monoesters

, 2022
Being the second leading cause of death and the leading cause of disability-adjusted life years worldwide, infectious diseases remaincontrary to earlier predictionsa major consideration for the public health of the 21st century. Resistance development of
Hanna Andersson (1408987), Linus Sandegren (12066), Manuela Vorácová (11998639), Anna Andersson Rasmussen (11998645), Lisa Allander (11998648), Susann Skagseth (11998642), Katarzyna Palica (11998636), Madlen Hubert (1963375), Hanna-Kirstirep Schrøder Leiros (11998651), Máté Erdélyi (1364241)   +9 more
core   +1 more source