Molecular Metabolism, 2019 Objective: Accumulation of visceral white adipose tissue (WAT) associates with insulin resistance, adipose tissue inflammation, and metabolic syndrome, whereas accumulation of subcutaneous WAT may be protective.
Alfred K. Ramirez +5 more
doaj +1 more source
Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection [PDF]
, 2017 Urinary tract infections: targeting enzymes might help Identifying bacterial and host enzymes that support biofilm formation may help prevent urinary tract infections caused by catheters.
Caparon, Michael G +5 more
core +3 more sources
Secretion of Metalloendopeptidase 24.15 (EC 3.4.24.15) [PDF]
DNA and Cell Biology, 1999 The metalloendopeptidase EP24.15 (EC3.4.24.15) is a neuropeptide-metabolizing enzyme present in neural and endocrine tissues, presumably functioning extracellularly. Because the majority of the EP24.15 activity is identified in the soluble fraction of cellular homogenates, suggesting that the enzyme is primarily an intracellular protein, we addressed ...
Ferro, E. S. +3 more
openaire +3 more sources
Adhesive and degradative properties of human placental cytotrophoblast cells in vitro. [PDF]
, 1989 Human fetal development depends on the embryo rapidly gaining access to the maternal circulation. The trophoblast cells that form the fetal portion of the human placenta have solved this problem by transiently exhibiting certain tumor-like properties ...
Cui, TY +7 more
core +3 more sources
Peptidic inhibitors of insulin-degrading enzyme with potential for dermatological applications discovered via phage display. [PDF]
PLoS ONE, 2018 Insulin-degrading enzyme (IDE) is an atypical zinc-metalloendopeptidase that hydrolyzes insulin and other intermediate-sized peptide hormones, many of which are implicated in skin health and wound healing.
Caitlin N Suire +7 more
doaj +1 more source
Heliyon, 2023 Nephrotic Syndrome is the most widespread pediatric kidney disorder. Genetic alterations in podocyte genes are thought to be responsible for the disease. G-quadruplexes are non-conventional guanine-rich DNA and RNA structures, which are commonly found in
Mona Saad +2 more
doaj +1 more source
Acute cocaine treatment increases thimet oligopeptidase in the striatum of rat brain [PDF]
, 2012 Many studies indicate that thimet oligopeptidase (EC3.4.24.15; TOP) can be implicated in the metabolism of bioactive peptides, including dynorphin 1-8, alpha-neoendorphin, beta-neoendorphin and GnRH.
Andersen, Monica Levy +13 more
core +1 more source
Secreted proteins as signalling molecules in Streptomyces development = Secreted proteins as signalling molecules in Streptomyces development [PDF]
, 2007 A streptomycesek Gram-pozitív, micéliális növekedésű mikroorganizmusok, melyek életciklusuk során komplex morfológiai differenciálódáson mennek keresztül, s ez jellemzően spóraképzéssel fejeződik be.
Biró, Sándor +1 more
core
Peripheral blood gene expression reveals an inflammatory transcriptomic signature in Friedreich's ataxia patients. [PDF]
, 2018 Transcriptional changes in Friedreich's ataxia (FRDA), a rare and debilitating recessive Mendelian neurodegenerative disorder, have been studied in affected but inaccessible tissues-such as dorsal root ganglia, sensory neurons and cerebellum-in animal ...
Coppola, Giovanni +11 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney +4 more
wiley +1 more source