Results 61 to 70 of about 6,440 (201)

The Secretome of Human Trophoblast Stem Cells Attenuates Senescence‐Associated Traits

Aging Cell, Volume 25, Issue 2, February 2026.
Human trophoblast stem cell‐derived secretome/conditioned medium (hTSC‐CM) and the extracellular vesicles (EVs) therein suppress DNA damage and NF‐κB activation in senescent fibroblasts, in turn reducing the production of senescence‐associated secretory phenotype (SASP) factors. This study highlights hTSC‐CM and EVs as potential senotherapeutic agents.
Kotb Abdelmohsen, Jennifer L. Martindale, Martina Rossi, Chang Hoon Shin, Apala Pal, Rachel Munk, Martin Salamini‐Montemurri, Mirko Baranzini, Ethan M. Arends, Maja Mustapic, Yuta Lee, Jau‐Nan Lee, Sicco H. Popma, Justin Hu, Nathan Duda, Carlos J. Nogueras‐Ortiz, Dimitrios Kapogiannis, Chang‐Yi Cui, Myriam Gorospe   +18 more
wiley   +1 more source

The immuneregulator role of neprilysin (NEP) in invertebrates [PDF]

, 2012
Neprilysin (NEP) represents an important enzyme in both vertebrates and invertebrates. In the present report we have focused our attention to invertebrates. In particular, a structure related to CD10/NEP as well as its activity in different tissues, such
A. Grimaldi, D. Malagoli, E. Ottaviani, M. de Eguileor   +3 more
core  

Seasonal phenotype‐specific expression of microRNAs during metamorphosis in the European map butterfly Araschnia levana

, 2020
The European map butterfly (Araschnia levana ) is a well‐known example of seasonal polyphenism because the spring and summer imagoes exhibit distinct morphological phenotypes.
Baudach, A., Mukherjee, K., Vilcinskas, A., Vogel, H.   +3 more
core   +1 more source

Secretome Profiling of Young Multipotent Stem Cells Reveals Angiogenic and Immunomodulatory Mechanisms Supporting Aged Neuromuscular Health

Aging Cell, Volume 25, Issue 2, February 2026.
Young multipotent muscle‐derived stem/progenitor cells (MDSPCs) secrete a unique profile of pro‐angiogenic and immunomodulatory proteins that are diminished with age. Systemic transplantation of young MDSPCs into naturally aged mice activates pathways in neuromuscular tissues, enhancing health and driving molecular, structural, and functional ...
Seth D. Thompson, Chelsea L. Rugel, Maddlyn R. Haller, Jodi L. Curtin, Sudarshan Dayanidhi, Mitra Lavasani   +5 more
wiley   +1 more source

Transcriptional factor regulation network and competitive endogenous RNA (ceRNA) network determining response of esophageal squamous cell carcinomas to neoadjuvant chemoradiotherapy [PDF]

PeerJ, 2019
Background Neoadjuvant chemoradiotherapy (nCRT) followed by surgery benefits survival for patients with esophageal squamous cell carcinomas (ESCC) compared with surgery alone, but the clinical outcomes of nCRT are heterogeneous.
Mingrui Shao, Wenya Li
doaj   +2 more sources

Chloroplast Proteins without Cleavable Transit Peptides [PDF]

, 2009
Most chloroplast proteins (cp proteins) are nucleus-encoded, synthesized on cytosolic ribosomes as precursor proteins containing a presequence (cTP), and post-translationally imported via the Tic/Toc complex into the organelle, where the cTP is removed ...
Armbruster, Ute, Aseeva, Elena, Dietzmann, Angela, Fenino, Elena, Hertle, Alexander, Leister, Dario, Makarenko, Elina, Pribil, Mathias, Scharfenberg, Michael, Schliebner, Ivo, Voigt, Christian, Zühlke, Jessica   +11 more
core   +1 more source

Echinacoside Improves Pulmonary Vascular Remodeling by Regulating the L‐ and T‐Type Ca2+ Channels in the Prevention and Treatment of Pulmonary Hypertension

Pulmonary Circulation, Volume 16, Issue 1, January 2026.
ABSTRACT The typical pathology of pulmonary hypertension (PH) is characterized by pulmonary vasoconstriction and irreversible pulmonary vascular remodeling. Vascular remodeling is the process of structural changes and cellular rearrangement of blood vessels due to injury and is a significant factor in conditions such as PH.
Yuefu Zhao, Jinyu Wang, Yujie Qiao, Xiangyun Gai, Jiacheng Hu, Hongmai Wang, Qingqing Xia, Qiuqin Hu, Zhanqiang Li, Cen Li, Hongtao Bi   +10 more
wiley   +1 more source

Differential Properties of Venom Peptides and Proteins in Solitary vs. Social Hunting Wasps

Toxins, 2016
The primary functions of venoms from solitary and social wasps are different. Whereas most solitary wasps sting their prey to paralyze and preserve it, without killing, as the provisions for their progeny, social wasps usually sting to defend their ...
Si Hyeock Lee, Ji Hyeong Baek, Kyungjae Andrew Yoon   +2 more
doaj   +1 more source

Virulence and Antimicrobial Resistance in Enterococci Isolated from Urinary Tract Infections [PDF]

, 2013
Purpose: Urinary tract infection (UTI) is the most common nosocomial infection among hospitalized patients. Meanwhile, most frequent infections involving enterococci affect the urinary tract.
Ahad Bazmani, Alka Hasani, Behrouz Naghili, Mohammad Aghazadeh, Mortaza Milani, Reza Ghotaslou, Yaeghob Sharifi   +6 more
core   +1 more source

Genomic Connectivity and Adaptation Signals of the Freshwater Sponge Ephydatia muelleri Across Its Distribution

Journal of Biogeography, Volume 53, Issue 1, January 2026.
ABSTRACT Aim Genetic connectivity and local adaptation were examined across the distribution of the freshwater sponge Ephydatia muelleri. Because it occupies an exceptional breadth of freshwater environments across a broad geographic range, this species offers key insights into biogeographic processes shaping genetic structure and adaptation in inland ...
Laura de la Cruz‐Castillejo, Robert Cassidy, Konstantina Mitsi, Carles Galià‐Camps, Ana Benítez‐López, Carlota Gracia‐Sancha, Jose Lorente‐Sorolla, Almudena Álvarez‐Fernández, Rocío Mozo, Stephen Kolomyjec, Scott Nichols, Renata Manconi, Raquel Pereira, Karen Evans, Valeria Itskovich, April L. Horton, Sally P. Leys, Sergi Taboada, Ana Riesgo   +18 more
wiley   +1 more source