Results 51 to 60 of about 5,484 (240)

Nicotinamide Riboside Improves Mitochondrial Function and Oocyte Maturation in Aged Mice: A Multitarget Mechanistic Study Using Network Pharmacology and Molecular Simulations

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Mitochondrial dysfunction plays a critical role in ovarian aging and the associated decline in female fertility. Nicotinamide riboside (NR), a vitamin B3 derivative and dietary NAD+ precursor, has shown antiaging potential, yet its molecular mechanisms in ovarian function are not fully understood.
Ningyu Sun, Xiang Cheng, Lu Lu, Wuwen Zhang, Kai Li, Yuanyuan Chen, Yun Li, Chunling Liu, Qinhua Zhang, Ping Yin, Anupama Bose   +10 more
wiley   +1 more source

Cholesterol‐Lowering and Radical Scavenging Potential of Fermented Black Kale (Brassica oleracea var. acephala): From Pilot‐Scale Production to in Vivo Study

ChemFoodChem, Volume 1, Issue 2, December 1, 2025.
Abstract Vegetables are rich in bioactive compounds, including fibers and minerals, providing a conspicuous contribution to achieving health benefits. In this study, black kale (Brassica oleracea var. acephala, BK) was fermented using Saccharomyces cerevisiae LI180‐7 strain at pilot scale, producing a safe and consumable product featured by improved ...
Mirco Vacca, Annamaria Tarantini, Mohamad Khalil, Danilo Vona, Francesco M. Calabrese, Giuseppe Celano, Carmen A. Apa, Matteo Bernardi, Leonardo Mancini, Gianni Pietragalla, Laura Mahdi, Domenico Rubino, Matteo Spagnuolo, Gianluca Bleve, Piero Portincasa, Maria De Angelis   +15 more
wiley   +1 more source

Stepwise metamorphosis of the tubeworm Hydroides elegans is mediated by a bacterial inducer and MAPK signaling [PDF]

, 2016
Diverse animal taxa metamorphose between larval and juvenile phases in response to bacteria. Although bacteria-induced metamorphosis is widespread among metazoans, little is known about the molecular changes that occur in the animal upon stimulation by ...
Antoshechkin, Igor, Medeiros, João M., Newman, Dianne K., Pilhofer, Martin, Shikuma, Nicholas J.   +4 more
core   +2 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

A Novel Hyaluronidase from Brown Spider (Loxosceles intermedia) Venom (Dietrich's Hyaluronidase): From Cloning to Functional Characterization [PDF]

, 2013
Loxoscelism is the designation given to clinical symptoms evoked by Loxosceles spider's bites. Clinical manifestations include skin necrosis with gravitational spreading and systemic disturbs. the venom contains several enzymatic toxins.
Chaim, Olga Meiri, Ferrer, Valeria Pereira, Gremski, Luiza Helena, Gremski, Waldemiro, Mari, Thiago Lopes de, Nader, Helena Bonciani, Senff-Ribeiro, Andrea, Silva, Dilza Trevisan, Silveira, Rafael Bertoni da, Veiga, Silvio Sanches   +9 more
core   +9 more sources

Metzincin's canonical methionine is responsible for the structural integrity of the zinc-binding site [PDF]

, 2017
The metzincins constitute a subclan of metalloproteases possessing a HEXXHXXGXXH/D zinc-binding consensus sequence where the three histidines are zinc ligands and the glutamic acid is the catalytic base.
Baumann, Ulrich, Bumann, Mario, Hege, Thomas, Oberholzer, Anselm E., Russo, Santina   +4 more
core  

The gene-expression profile of renal medulla in ISIAH rats with inherited stress-induced arterial hypertension [PDF]

, 2016
Metabolic pathways enriched with genes differentially expressed in ISIAH and WAG renal medulla.
Arcady L. Markel, Larisa A. Fedoseeva, Marina A. Ryazanova, Nikita I. Ershov, Olga E. Redina, Vadim M. Efimov   +5 more
core   +6 more sources

Megathrust Earthquake Legacy Linked to Changes in Widespread Potential for Methane and Iron Cycling in Glaciated Wetlands

AGU Advances, Volume 6, Issue 5, October 2025.
Abstract Freshwater wetlands are major sources of global methane emissions through biogenic methanogenesis, a process increasingly influenced by climate change. High latitude wetlands are subject to uniquely altered biogeochemical inputs due to disproportionate warming.
Jessica Z. Buser‐Young, Byron C. Crump, Nicolas Harrichhausen, Frederick S. Colwell   +3 more
wiley   +1 more source

The Life of a Kidney Podocyte

Acta Physiologica, Volume 241, Issue 8, August 2025.
ABSTRACT Aim Podocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective
Desiree Loreth, Wiebke Sachs, Catherine Meyer‐Schwesinger   +2 more
wiley   +1 more source

The Extracellular Vesicles of the Helminth Pathogen, Fasciola hepatica: Biogenesis Pathways and Cargo Molecules Involved in Parasite Pathogenesis [PDF]

, 2015
Extracellular vesicles (EVs) released by parasites have important roles in establishing and maintaining infection. Analysis of the soluble and vesicular secretions of adult Fasciola hepatica has established a definitive characterization of the total ...
Bernal, Dolores, Brennan, Gerard P, Cwiklinski, Krystyna, Dalton, John P, de la Torre-Escudero, Eduardo, Dufresne, Philippe J, Marcilla, Antonio, O'Neill, Sandra, Paterson, Steve, Robinson, Mark W, Tort, Jose, Trelis, Maria   +11 more
core   +1 more source