Results 101 to 110 of about 23,484 (216)

Phase Separation of Nucleic Acids: Mechanisms, Properties, and Applications

Angewandte Chemie International Edition, Volume 65, Issue 11, 9 March 2026.
Recent discoveries have shown that single‐stranded long‐chain nucleic acids can undergo temperature‐induced phase separation, enabling formation of micrometer‐sized condensates. This Minireview discusses the current mechanistic understanding of this phenomenon, highlights strategies for controlling the physical and chemical properties of these ...
Weixiang Chen, Johann Fritzen, Andreas Walther   +2 more
wiley   +1 more source

Metalloenzymes as Therapeutic Targets

Current Medicinal Chemistry, 2019

Barbara, Richichi, Georgios A, Spyroulias, Jean-Yves, Winum, Raivis, Žalubovskis   +3 more
openaire   +2 more sources

The search for exudates from Eurasian watermilfoil and hydrilla [PDF]

, 2002
Secondary metabolites are produced by aquatic plants, and in some instances, exudation of these metabolites into the surrounding water has been detected.
Glomski, Lee Ann M., Lembi, C.A., Nicholson, R.L., Wood, K.V.   +3 more
core  

Cobalt‐Salen Catalysed Hydration of Alkenes With Water: A Complementary Ionic Approach to the Mukaiyama Hydration

Advanced Synthesis &Catalysis, Volume 368, Issue 5, 3 March 2026.
A cobalt‐salen catalysed hydration of olefins with water is reported, resulting in Markovnikov alcohol products. The reaction proceeds rapidly under mild conditions and exhibits excellent functional group tolerance, supporting a wide range of styrenyl and non‐activated alkenes.
David G. Groves, Reece H. Hoogesteger, Balakumar Emayavaramban, Craig P. Johnston   +3 more
wiley   +1 more source

Editorial: Metalloenzymes: Potential Drug Targets

Frontiers in Pharmacology, 2021
Jamshed Iqbal, Claus Jacob, Jean Sévigny, Jean Sévigny   +3 more
doaj   +1 more source

Antagonistic effect of rhizospheric bacteria against white rot (Sclerotium cepivorum) of garlic (Allium sativum L.) under in vitro and in vivo conditions

Agrosystems, Geosciences &Environment, Volume 9, Issue 1, March 2026.
Abstract Garlic (Allium sativum), a vegetable crop used for food, medicine, and condiments, is affected by white rot (Sclerotium cepivorum). Garlic yield reduction is influenced by several factors, with biotic stresses, particularly fungal pathogens, being among the most significant.
Mussa Adal Mohammed, Asmare Dejen Demeke
wiley   +1 more source

Inhibition of α-, β-, γ-, and δ-carbonic anhydrases from bacteria and diatoms with N′-aryl-N-hydroxy-ureas

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
The inhibition of α-, β-, γ-, and δ-class carbonic anhydrases (CAs, EC 4.2.1.1) from bacteria (Vibrio cholerae and Porphyromonas gingivalis) and diatoms (Thalassiosira weissflogii) with a panel of N’-aryl-N-hydroxy-ureas is reported. The α-/β-CAs from V.
Emanuela Berrino, Murat Bozdag, Sonia Del Prete, Fatmah A. S. Alasmary, Linah S. Alqahtani, Zeid AlOthman, Clemente Capasso, Claudiu T. Supuran   +7 more
doaj   +1 more source

Chromones as Nonclassical Inhibitors of Carbonic Anhydrase IX and XII Isoforms: Probing Chromone‐Based Derivatives

Archiv der Pharmazie, Volume 359, Issue 3, March 2026.
Chromone‐based derivatives were synthesized and evaluated for selective inhibition of tumor‐associated carbonic anhydrases IX and XII. Structure–activity relationships, docking studies, and ADMET profiling revealed promising candidates with selective tumoral isoform inhibition, supporting their potential as anticancer leads. ABSTRACT A small library of
Lisa Sequeira, Simona Distinto, Carlos Fernandes, Erica Sanna, Rita Meleddu, Marco Gaspari, Filippo Cottiglia, Alessia Onali, Andrea Angeli, Fernanda Borges, Eugenio Uriarte, Stefano Alcaro, Claudiu T. Supuran, Elias Maccioni   +13 more
wiley   +1 more source

Activation studies of the α- and β-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae with amines and amino acids

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
The α- and β-class carbonic anhydrases (CAs, EC 4.2.1.1) from the pathogenic bacterium Vibrio cholerae, VchCAα, and VchCAβ, were investigated for their activation with natural and non-natural amino acids and amines.
Andrea Angeli, Sonia Del Prete, Sameh M. Osman, Fatmah A. S. Alasmary, Zeid AlOthman, William A. Donald, Clemente Capasso, Claudiu T. Supuran   +7 more
doaj   +1 more source

CA IX Inhibition by a Sulfonamide Compound: A Therapeutic Approach Against Breast Cancer

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
Synergistic Efficacy of MMH‐I and 5‐Fluorouracil Combination Therapy in CA IX‐Expressing Breast Cancer Models: Pathological and Metabolic Insights. ABSTRACT Carbonic anhydrase IX (CA IX) is overexpressed in many solid tumors, contributing to cancer cell proliferation, survival, invasion, and metastasis.
Sükrü Akmese, Ebru Temiz, Elif Gürel, Ismail Koyuncu, Mustafa Durgun, Muhammet Emin Guldur, Kadir Egi, Beyza Ozerol   +7 more
wiley   +1 more source