Results 51 to 60 of about 4,715 (225)

Comparative transcriptomic analysis of two important life stages of Angiostrongylus cantonensis: fifth-stage larvae and female adults

Genetics and Molecular Biology
The mechanisms involved in the fast growth of Angiostrongylus cantonensis from fifth-stage larvae (L5) to female adults and how L5 breaks through the blood-brain barrier in a permissive host remain unclear. In this work, we compared the transcriptomes of
Liang Yu, Binbin Cao, Ying Long, Meks Tukayo, Chonglv Feng, Wenzhen Fang, Damin Luo   +6 more
doaj   +1 more source

AIP56: A Novel Bacterial Apoptogenic Toxin

Toxins, 2010
Photobacterium damselae subsp. piscicida (Phdp) is a Gram-negative pathogen agent of an important fish septicemia. The key virulence factor of Phdp is the plasmid-encoded exotoxin AIP56, which is secreted by exponentially growing pathogenic strains ...
Manuel T. Silva, Nuno M. S. dos Santos, Ana do Vale   +2 more
doaj   +1 more source

LmaPA2G4, a homolog of human Ebp1, is an essential gene and inhibits cell proliferation in L. major. [PDF]

PLoS Neglected Tropical Diseases, 2014
We have identified LmaPA2G4, a homolog of the human proliferation-associated 2G4 protein (also termed Ebp1), in a phosphoproteomic screening. Multiple sequence alignment and cluster analysis revealed that LmaPA2G4 is a non-peptidase member of the M24 ...
Brianna Norris-Mullins, Kaitlin VanderKolk, Paola Vacchina, Michelle V Joyce, Miguel A Morales   +4 more
doaj   +1 more source

Two New M23 Peptidoglycan Hydrolases With Distinct Net Charge

Frontiers in Microbiology, 2021
Bacterial peptidoglycan hydrolases play an essential role in cell wall metabolism during bacterial growth, division, and elongation (autolysins) or in the elimination of closely related species from the same ecological niche (bacteriocins).
Alicja Wysocka, Elżbieta Jagielska, Łukasz Łężniak, Izabela Sabała   +3 more
doaj   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

MMP19 (matrix metallopeptidase 19) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2014
Review on MMP19, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
Chan, KC, Lung, ML
openaire   +2 more sources

Functional and Proteomic Characterization of Acanthophis antarcticus Venom: Evidence of Fibrinogenolytic and Serine Peptidase Inhibitory Activities

Toxins
Acanthophis antarcticus, commonly known as the death adder, is a venomous Australian snake and a member of the Elapidae family. Due to its robust body and triangular head, it was historically misclassified as a viper.
Monica V. Falla, Enzo P. Sousa, Karen de Morais-Zani, Rodrigo Valladão, Natalia G. Santos, Nathalia C. Galizio, Mariana S. Rodrigues, Heloisa F. Almeida, Adriana R. Lopes, Mauricio N. Moises, Ivo Lebrun, Patrick J. Spencer, Daniel C. Pimenta, Guilherme R. Coelho   +13 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Extracellular vesicle microRNA and protein cargo profiling in three clinical-grade stem cell products reveals key functional pathways

Molecular Therapy: Nucleic Acids, 2023
The cell origin-specific payloads within extracellular vesicles (EVs) mediate therapeutic bioactivity for a wide variety of stem cell types. In this study, we profiled the microRNA (miRNA) and protein cargos found within EVs produced by three clinical ...
Ramana Vaka, Sandrine Parent, Yousef Risha, Saad Khan, David Courtman, Duncan J. Stewart, Darryl R. Davis   +6 more
doaj   +1 more source