Results 71 to 80 of about 4,715 (225)

In Silico Predictions of Ecological Plasticity Mediated by Protein Family Expansions in Early-Diverging Fungi

Journal of Fungi, 2022
Early-diverging fungi (EDF) are ubiquitous and versatile. Their diversity is reflected in their genome sizes and complexity. For instance, multiple protein families have been reported to expand or disappear either in particular genomes or even whole ...
Małgorzata Orłowska, Anna Muszewska
doaj   +1 more source

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Theoretical Insights into the Functioning of Metallopeptidases and Their Synthetic Analogues

, 2015
Conspectus The selective hydrolysis of a peptide or amide bond (−(O)­C–NH−) by a synthetic metallopeptidase is required in a wide range of biological, biotechnological, and industrial applications. In nature, highly specialized enzymes known as proteases
Barman, Arghya, Zhang, Tingting, Ozbil, Mehmet, Bora, Ram Prasad, Paul, Thomas J, Prabhakar, Rajeev   +5 more
core   +1 more source

The Therapeutic Potential of Adipose Tissue-Derived Mesenchymal Stem Cells to Enhance Radiotherapy Effects on Hepatocellular Carcinoma

Frontiers in Cell and Developmental Biology, 2019
Several studies have investigated strategies to improve the clinical efficacy of radiotherapy (RT) against hepatocellular carcinoma (HCC), yet the prognosis remains poor.
Lingyun Wu, Qiuying Tang, Xin Yin, DanFang Yan, Mengmeng Tang, Jiaojiao Xin, Qiaoling Pan, Chiyuan Ma, Senxiang Yan   +8 more
doaj   +1 more source

Intracellular pH regulates amyloid precursor protein intracellular domain accumulation

Neurobiology of Disease, 2007
The amyloid precursor protein (APP) metabolism is central to pathogenesis of Alzheimer’s disease (AD). Parenchymal amyloid deposits, a neuropathological hallmark of AD, are composed of amyloid-beta peptides (Abeta).
Valérie Vingtdeux, Malika Hamdane, Séverine Bégard, Anne Loyens, André Delacourte, Jean-Claude Beauvillain, Luc Buée, Philippe Marambaud, Nicolas Sergeant   +8 more
doaj   +1 more source

Multiple Architectures and Mechanisms of Latency in Metallopeptidase Zymogens [PDF]

Chemical Reviews, 2018
Metallopeptidases cleave polypeptides bound in the active-site cleft of catalytic domains through a general base/acid mechanism. This involves a solvent molecule bound to a catalytic zinc and general regulation of the mechanism through zymogen-based latency.
Joan L. Arolas, Theodoros Goulas, Anna Cuppari, F. Xavier Gomis-Rüth   +3 more
openaire   +2 more sources

Proteolytic Matrix Metallopeptidases and Inhibitors in BCR-ABL1-Negative Myeloproliferative Neoplasms: Correlation with JAK2^V617F Mutation Status

, 2011
<i>Background/Aims:</i> Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) share the same acquired lesion JAK2^V617F and may exhibit substantial overlap. Variability in JAK activation and allele burden,
C.M. Vadikolia, C. Tsatalas, D. Pantelidou, E. Spanoudakis, I. Bazdiara, G. Bourikas, A. Anastasiadis, G. Trypsianis, K. Anagnostopoulos, I. Kotsianidis, A. Kortsaris, D. Margaritis   +11 more
core   +1 more source

Metallopeptidase inhibition potentiates bradykinin-induced hyperalgesia [PDF]

Pain, 2011
The neuropeptide bradykinin (BK) sensitizes nociceptor activation following its release in response to inflammatory injury. Thereafter, the bioactivity of bradykinin is controlled by the enzymatic activities of circulating peptidases. One such enzyme, the metalloendopeptidase EC3.4.24.15 (EP24.15), is co-expressed with bradykinin receptors in primary ...
Ruben, Gomez, Elaine D, Por, Kelly A, Berg, William P, Clarke, Marc J, Glucksman, Nathaniel A, Jeske   +5 more
openaire   +2 more sources

Plasma Proteome Reflects Tissue Damage and Clinical Manifestations in Patients With Inflammatory Myopathies

Arthritis &Rheumatology, EarlyView.
Objective Tissue‐specific biomarkers that are reliable and associated with clinical manifestations of idiopathic inflammatory myopathy (IIM) are lacking. The blood circulation in individuals serves as a central conduit, allowing communication between tissues and facilitating clearance and recycling of tissue‐derived proteins.
Yue‐Bei Luo, Josefin Kenrick, Angeles S. Galindo‐Feria, Antonella Notarnicola, Ana Daniela Ulloa Navas, Irene Peralta‐Garcia, Orane Demuynck, Andrea Kemp, Valérie Leclair, Karin Lodin, Eveline Van Gompel, Lara Dani, Fabricio Espinosa‐Ortega, Maryam Dastmalchi, Leonid Padyukov, Charlotta Preger, María Bueno Álvez, Mathias Uhlén, Peter Nilsson, Fredrik Edfors, Lina‐Marcela Diaz‐Gallo, Elisa Pin, Ingrid E. Lundberg, Begum Horuluoglu   +23 more
wiley   +1 more source

Pharmacological activation of neurolysin and associated metallopeptidases for therapeutic applications

, 2022
Metallopeptidases (MPs; EC subclass 3.4.24), are the most diverse group of peptidases with wide-ranging roles in the processing and function of biologically active peptides in mammalian organisms.
Hadi Esfahani, Shiva
core