Results 61 to 70 of about 4,715 (225)
Advanced Science, EarlyView.ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu +10 more
wiley +1 more source
The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases
Frontiers in Immunology, 2017 Antigenic peptides presented by the major histocompatibility complex class I (MHC-I) molecules for recognition by cytotoxic T-lymphocytes are processed by members of the oxytocinase sub-family of M1 aminopeptidases ERAP1, ERAP2, and IRAP.
Athanasios Papakyriakou +2 more
doaj +1 more source
Structural and sequence analysis of imelysin-like proteins implicated in bacterial iron uptake. [PDF]
PLoS ONE, 2011 Imelysin-like proteins define a superfamily of bacterial proteins that are likely involved in iron uptake. Members of this superfamily were previously thought to be peptidases and were included in the MEROPS family M75.
Qingping Xu +14 more
doaj +1 more source
Precision Medicine Approaches to Prevent Gastric Cancer
Gut and Liver, 2021 Gastric cancer remains one of the most common causes of cancer-related death worldwide, although the incidence is declining gradually. The primary risk factor for gastric cancer is Helicobacter pylori infection.
Juntaro Matsuzaki +2 more
doaj +1 more source
Advanced Science, EarlyView.Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl +20 more
wiley +1 more source
Computational Insights into the Mechanisms and Structures of Peptide Bond Cleaving Metalloenzymes and Their Synthetic Analogues [PDF]
, 2016 The selective hydrolysis of peptide or amide bond is required in a wide range of biological, biotechnological and industrial applications. There are significant kinetic barriers to these reactions since peptide bonds are extremely stable and possess a ...
Zhang, Tingting
core +3 more sources
Advanced Science, EarlyView.Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng +12 more
wiley +1 more source
Effect of nanoparticles on the expression and activity of matrix metalloproteinases
Nanotechnology Reviews, 2018 Matrix metallopeptidases, commonly known as matrix metalloproteinases (MMPs), are a group of proteolytic enzymes whose main function is the remodeling of the extracellular matrix. Changes in the activity of these enzymes are observed in many pathological
Matysiak-Kucharek Magdalena +4 more
doaj +1 more source
PLoS ONE, 2020 Despite increasing research on the gut-skin axis, there is a lack of comprehensive studies on the improvement of skin health through the regulation of the intestinal condition in humans.
Bora Nam +9 more
doaj +1 more source
Bioinformatic mapping of a more precise Aspergillus niger degradome
Scientific Reports, 2021 Aspergillus niger has the ability to produce a large variety of proteases, which are of particular importance for protein digestion, intracellular protein turnover, cell signaling, flavour development, extracellular matrix remodeling and microbial ...
Zixing Dong +2 more
doaj +1 more source