Results 101 to 110 of about 5,434 (205)

Potential Cytoprotective and Anti-Apoptotic Effect of Metamizole Alone and in Combination with Cytostatic Drugs Observed In Vitro in Canine (D-17) and Human (U-2 OS) Osteosarcoma Cell Lines

Biomedicines
Metamizole (dipyrone) is still a frequently used drug in human and veterinary medicine, especially for pain relief, sometimes also in osteosarcoma treatment.
Dominik Poradowski, Aleksander Chrószcz, Radosław Spychaj, Vedat Onar   +3 more
doaj   +1 more source

Influence of Nonopioid Analgesics on Healthy Nucleus Pulposus Cells

Global Spine Journal, 2014
Introduction Recent advances in our understanding of intervertebral disc biology led to an increased interest in the development of cell transplantation therapies.
C. Eder, J. Trifinopoulos, S. Schildboeck, N. Koppensteiner, J. Zolles, E. Falkner, M. Ogon   +6 more
doaj   +1 more source

Discovering interactions in polypharmacy: Impact of metamizole on the metabolism of quetiapine [PDF]

Aims Metamizole is quite an old drug with analgesic, antipyretic and spasmolytic properties. Recent findings have shown that it may induce several cytochrome P450 (CYP) enzymes, especially CYP3A4 and CYP2B6. The clinical relevance of these properties is
Schoretsanitis, Georgios; https://orcid.org/, Neuner, Irene; https://orcid.org/, Hiemke, Christoph; https://orcid.org/, Watermeyer, Fabian, Gaebler, Arnim Johannes; https://orcid.org/, Haen, Ekkehard; https://orcid.org/, Paulzen, Michael; https://orcid.org/   +6 more
core   +1 more source

The effect of metoclopramide on the antinociceptive, locomotor and neurobehavioral effects of metamizole in mice

Macedonian Veterinary Review
Combining analgesic medications with distinct pharmacodynamics may result in effective analgesia and reduced adverse effects by lowering dosages of one or both medications. The objective was to investigate the nature of interactions of metoclopramide and
Zena Sattam Hamed, Khalid Ahmed Shaban, Ghada Abdul-Munem Faris   +2 more
doaj   +1 more source

Chronic use of metamizole: not so safe after all?

, 2017
Item does not contain fulltextMetamizole can be used in both short- and long-term pain relief therapies and has a relatively favourable safety profile compared with classic NSAIDs.
Koehestanie, P., Vuik, F.E., Terhaar sive Droste, J.S., Herbers, A.H.   +3 more
core  

Effects of Metamizole, 4-Methylaminoantipyrine, and 4-Aminoantipyrine on LX-2 Liver Cell Line Viability and Apoptosis

Molecules
Metamizole (dipyrone) is a non-opioid analgesic widely used in human and veterinary medicine, despite ongoing concerns about its safety due to risks such as agranulocytosis and potential hepatotoxicity.
Georgiana-Iulia Lupu, Emoke Pall, Mihai Cenariu, Monica Irina Nan, Sanda Andrei   +4 more
doaj   +1 more source

Selective induction of human hepatic cytochromes P450 2B6 and 3A4 by metamizole

, 2007
The pyrazolone drug metamizole is a widely used analgesic. Analysis of liver microsomes from patients treated with metamizole revealed selectively higher expression of cytochromes P450, CYP2B6 and CYP3A4 (3.8- and 2.8-fold, respectively), and 2.9-fold ...
Schwab, M., Hengstler, J., Burk, O., Eichelbaum, M., Nussler, A., Zanger, U., Blievernicht, J., Saussele, T., Nussler, N.   +8 more
core   +1 more source

SYNERGISM OF THE ANALGESIC ACTIVITY OF METAMIZOLE SODIUM WITH KETAMINE AND DEXMEDETOMIDINE IN MULTIMODAL ANALGESIA IN A MODEL OF ACUTE VISCERAL PAIN

Клінічна та профілактична медицина
Introduction. Multimodal analgesia is a cornerstone of opioid-sparing strategies for acute pain management. Metamizole is a widely used non-opioid analgesic with combined peripheral and central mechanisms; however, its potentiation by central adjuvants ...
Mariia V. Matvieienko, Mykola O. Chyzh, Fedir V. Hladkykh, Olha V. Basarab, Madona O. Gogiya   +4 more
doaj   +1 more source

Dipyrone (metamizole)

, 2018
Dipyrone (metamizole) is a non-opioid analgesic commonly used in Germany, which can, in very rare cases, cause life-threatening agranulocytosis. The prescribing information calls for regular monitoring of the differential blood count in cases of long-term treatment.
Stamer, Ulrike M., Gundert-Remy, Ursula, Biermann, E., Erlenwein, Joachim, Meissner, W., Wirz, Stefan, Stammschulte, T.   +6 more
openaire   +1 more source

Data Metamizole Acceptance Rat

Data concerning the following project/manuscript:No option for analgesia refinement: Sprague-Dawley rats reject voluntary ingestion of metamizole via drinking water or palatable carrier media Background: The non-opioid analgesic metamizole (MET) is ...
Glasenapp, Aylina, Bankstahl, Jens P., Moraga-Amaro, Rodrigo, Timartas, Derya, Bankstahl, Marion   +4 more
core   +1 more source