Results 81 to 90 of about 5,839 (199)

Metamizole-induced agranulocytosis: utilisation trends, pharmacovigilance signals and regulatory risk-minimisation in Switzerland

Swiss Medical Weekly
 INTRODUCTION: The therapeutic role of metamizole (dipyrone) remains controversial because of the risk of metamizole-induced agranulocytosis, a very rare, idiosyncratic, life-threatening adverse reaction.
Oliver Wildner, Isabelle Wenker, Stephanie Storre, Thomas Stammschulte   +3 more
doaj   +1 more source

Efek Proteksi Otak Metamizol Intravena Sebagai Farmakologik Hipotermi Terhadap Suhu Inti Dan Kadar Interleukin-6 Pada Pasien Cedera Kepala Berat

Jurnal Neuroanestesi Indonesia, 2017
Latar Belakang dan Tujuan: Cedera kepala berat merupakan salah satu penyebab mortalitas dan morbiditas bagi pasien pasca trauma. Sirkulasi sitokin interleukin-6 (IL-6) pada cedera kepala berat dan proteksi otak dalam pengaturan suhu berhubungan dengan ...
Muhammad Erias, Ruli Herman Sitanggang, Tatang Bisri   +2 more
doaj   +1 more source

Diagnosis and management of neutropenia in adults: Expert guidance

British Journal of Haematology, Volume 209, Issue 2, Page 432-440, August 2026.
Severe neutropenia can result from decreased production of neutrophil precursors in the bone marrow, as in the case of severe congenital neutropenia, or from increased utilization of neutrophils or their accelerated destruction as for drug‐induced neutropenia or autoimmune neutropenia. Severe chronic neutropenia increases susceptibility to bacterial or
Karl Welte, Cornelia Zeidler, Julia Skokowa, Sabine Mellor‐Heineke, Audrey Anna Bolyard, David Dale   +5 more
wiley   +1 more source

HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ASSAY OF METAMIZOLE, THIAMINE AND PYRIDOXINE IN TABLET [PDF]

, 2016
The aim of the present study was develop and validate HPLC method for the simultaneous assay of metamizole, thiamine and pyridoxine in tablet. Metamizole is a substance that is easily hydrolyzed in the presence of water and oxygen.
Maritha, Vevi
core   +1 more source

Metabolism and Drug-Drug Interaction Studies of Metamizole in Humans [PDF]

, 2021
Metamizole is a non-opioid analgesic with additional antipyretic and spasmolytic properties. It was introduced nearly 100 years ago, but due to a severe but rare side-effect agranulocytosis, it has been withdrawn from the market in several countries ...
Bachmann, Fabio
core  

Allergic Reactions to Metamizole: Immediate and Delayed Responses [PDF]

, 2016
[EN] Background: Pyrazolones are the most common causes of selective nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity. We studied a large group of patients with immediate and delayed selective responses to metamizole.
Blanca-López, Natalia, Cornejo-Garcia, José Antonio, Agúndez, Jose A.G., Pérez-Sanchez, Natalia, Blanca, Miguel, Canto, María Gabriela, Mayorga, Cristobalina, Torres, Maria José, Perkins, James R., Miranda Alonso, Miguel Ángel, Doña, Inmaculada, García-Martín, Elena, Andreu, Inmaculada   +12 more
core   +1 more source

Hematological safety of metamizole: retrospective analysis of WHO and Swiss spontaneous safety reports [PDF]

, 2021
Purpose: Since the 1970s, the use of metamizole is controversial due to the risk of agranulocytosis. The aim of this study was to analyze individual case safety reports (ICSRs) of metamizole-associated hematological adverse drug reactions (ADRs). Methods:
Tramonti, Alexandra, Krähenbühl, Stephan, Blaser, Lea, Haschke, Manuel, Rätz Bravo, Alexandra, Egger, Pascal   +5 more
core  

Metamizole (dipyrone) [PDF]

Klinická farmakologie a farmacie, 2021
Jitka Rychlíčková, Hana Jurečková
openaire   +1 more source

The Adequacy of Anesthesia Guidance for Vitreoretinal Surgeries with Preemptive Paracetamol/Metamizole

Pharmaceuticals
Despite the possibility of postoperative pain occurrence, in some patients, vitreoretinal surgeries (VRSs) require performance of general anesthesia (GA).
Michał Jan Stasiowski, Anita Lyssek-Boroń, Nikola Zmarzły, Kaja Marczak, Beniamin Oskar Grabarek   +4 more
doaj   +1 more source

Dose evaluation of intravenous metamizole (dipyrone) in infants and children: a prospective population pharmacokinetic study. [PDF]

, 2019
PURPOSE: The prodrug metamizole is prescribed intravenously for postoperative pain in children, including off-label use in infants
Bachmann, Fabio, Bielicki, Julia A, van den Anker, JN, Holland-Cunz, S, Atkinson, Andrew, Borter, Carole, Holland-Cunz, Stefan, Atkinson, A, Haschke, M, Erb, Thomas O, Gürtler, N, Pfister, Marc, Duthaler, U, Haschke, Manuel, Gotta, V, Erb, TO, Pfister, M, Borter, C, Ziesenitz, Victoria C, Bachmann, F, van den Anker, Johannes N, Gürtler, Nicolas, Gotta, Verena, Ziesenitz, VC, Bielicki, JA, Rodieux, Frédérique, Rodieux, F, Duthaler, Urs   +27 more
core   +2 more sources