Results 81 to 90 of about 5,434 (205)

Constitutional symptoms and response to Penicillin G in erysipelas and cellulitis – a monocentric, retrospective, explorative study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 6, Page 746-754, June 2026.
Summary Background: Erysipelas, caused by streptococci, should be treated with penicillin, while uncomplicated cellulitis (phlegmon), often caused by Staphylococcus aureus, requires penicillinase‐resistant beta‐lactam antibiotics, which have a higher risk of adverse effects. Distinguishing between these infections is important.
Helena Schieffers, Cord Sunderkötter
wiley   +1 more source

Dose evaluation of intravenous metamizole (dipyrone) in infants and children: a prospective population pharmacokinetic study. [PDF]

, 2019
PURPOSE: The prodrug metamizole is prescribed intravenously for postoperative pain in children, including off-label use in infants
Bachmann, Fabio, Bielicki, Julia A, van den Anker, JN, Holland-Cunz, S, Atkinson, Andrew, Borter, Carole, Holland-Cunz, Stefan, Atkinson, A, Haschke, M, Erb, Thomas O, Gürtler, N, Pfister, Marc, Duthaler, U, Haschke, Manuel, Gotta, V, Erb, TO, Pfister, M, Borter, C, Ziesenitz, Victoria C, Bachmann, F, van den Anker, Johannes N, Gürtler, Nicolas, Gotta, Verena, Ziesenitz, VC, Bielicki, JA, Rodieux, Frédérique, Rodieux, F, Duthaler, Urs   +27 more
core   +1 more source

Metamizole-induced agranulocytosis: utilisation trends, pharmacovigilance signals and regulatory risk-minimisation in Switzerland

Swiss Medical Weekly
 INTRODUCTION: The therapeutic role of metamizole (dipyrone) remains controversial because of the risk of metamizole-induced agranulocytosis, a very rare, idiosyncratic, life-threatening adverse reaction.
Oliver Wildner, Isabelle Wenker, Stephanie Storre, Thomas Stammschulte   +3 more
doaj   +1 more source

Allgemeinsymptome und Ansprechen auf Benzylpenicillin bei Erysipel und unkomplizierter Phlegmone – eine monozentrische, retrospektive, explorative Studie

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 6, Page 746-754, June 2026.
Zusammenfassung Hintergrund Erysipele gelten als durch Streptokokken verursachte Infektionen und sollen daher mit Penicillin behandelt werden, während Phlegmonen meist durch Staphylococcus aureus hervorgerufen werden und Penicillinase‐feste Betalaktamantibiotika benötigen. Letztere bergen ein höheres Risiko für unerwünschte Wirkungen.
Helena Schieffers, Cord Sunderkötter
wiley   +1 more source

Hematological safety of metamizole: retrospective analysis of WHO and Swiss spontaneous safety reports [PDF]

, 2021
Purpose: Since the 1970s, the use of metamizole is controversial due to the risk of agranulocytosis. The aim of this study was to analyze individual case safety reports (ICSRs) of metamizole-associated hematological adverse drug reactions (ADRs). Methods:
Tramonti, Alexandra, Krähenbühl, Stephan, Blaser, Lea, Haschke, Manuel, Rätz Bravo, Alexandra, Egger, Pascal   +5 more
core  

Factors associated with potentially inappropriate medication use, medication underuse and overuse in older adults in the German National Cohort

Journal of Internal Medicine, Volume 299, Issue 6, Page 754-775, June 2026.
Abstract Background Effectively identifying individuals exposed to drug underuse, overuse and potentially inappropriate medication (PIM) in older adults is essential for minimizing preventable drug‐related harms. Methods We analysed data from 54,296 individuals aged 60–74 years from the German National Cohort (NAKO).
Miriam Degen, Ulrike Haug, Oliver H. F. Scholle, Yaw Awuku‐Larbi, Sigrid Carlsson, Nina Ebert, Volker Harth, Anja M. Hauri, Margit Heier, Anne Herrmann, Michael Leitzmann, Jakob Linseisen, Claudia Meinke‐Franze, Nadia Obi, Phil Pendt, Thomas Reinhold, Barbara Thorand, Hermann Brenner, Ben Schöttker   +18 more
wiley   +1 more source

Metamizole relieves pain by influencing cytokine levels in dorsal root ganglia in a rat model of neuropathic pain [PDF]

, 2020
Background Treatment of neuropathic pain is still challenging. Recent studies have suggested that dorsal root ganglia (DRG), which carry sensory neural signals from the peripheral nervous system to the central nervous system, are important for ...
Makuch, Wioletta, Piotrowska, Anna, Zajączkowska, Renata, Rojewska, Ewelina, Mika-Kula, Joanna, Kwiatkowski, Klaudia, Wordliczek, Jerzy, Pawlik, Katarzyna   +7 more
core   +1 more source

Enhancing Preclinical Rigor: Evaluating Robustness and Numerical Stability in a Chronic Pancreatitis Mouse Model

Annals of the New York Academy of Sciences, Volume 1560, Issue 1, June 2026.
In a modified cerulein‐induced chronic pancreatitis (CP) mouse model, key hallmarks of CP were robustly induced in male and female C57BL/6J (BL6) and BALB/c mice, whereas cytokine responses varied partly according to strain and sex. The RORγt inhibitor GSK805 reduced Il23r expression in the BL6 strain, significantly decreased collagen I deposition and ...
Annika Thämlitz, Muhammad Imran Khan, Benjamin Schulz, Lorenzo Pilch, Brigitte Vollmar, Dietmar Zechner   +5 more
wiley   +1 more source

Allergic Reactions to Metamizole: Immediate and Delayed Responses [PDF]

, 2016
[EN] Background: Pyrazolones are the most common causes of selective nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity. We studied a large group of patients with immediate and delayed selective responses to metamizole.
Blanca-López, Natalia, Cornejo-Garcia, José Antonio, Agúndez, Jose A.G., Pérez-Sanchez, Natalia, Blanca, Miguel, Canto, María Gabriela, Mayorga, Cristobalina, Torres, Maria José, Perkins, James R., Miranda Alonso, Miguel Ángel, Doña, Inmaculada, García-Martín, Elena, Andreu, Inmaculada   +12 more
core   +1 more source

Efek Samping Agranulositosis Imbas Metamizole: Kajian Pustaka

Agranulositosis merupakan kondisi yang jarang terjadi, namun dapat berpotensi fatal dan menyebabkan kematian apabila tidak ditindaklanjuti secara tepat dan cepat. Insidensi agranulositosis yaitu 6,2 juta kasus/penduduk/tahun.
Pribadi, Ezra Immanuelly, Marzuki, Jefman Efendi, Herawati, Fauna   +2 more
core   +1 more source