Neural regulation of cancer: from mechanobiology to inflammation. [PDF]
Despite recent progress in cancer research, the exact nature of malignant transformation and its progression is still not fully understood. Particularly metastasis, which accounts for most cancer death, is a very complex process, and new treatment ...
Kim, Tae-Hyung+2 more
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First description of cervical intradural thymoma metastasis [PDF]
Thymoma and thymic carcinoma are rare epithelial tumors, which originate from the thymus gland. According to the World Health Organization there are "organotypic" (types A, AB, B1, B2, and B3) and "non-organotypic" (thymic carcinomas) thymomas.
Colistra, Davide+5 more
core +1 more source
Abstract Aggressive primary tumors express transcriptional signatures that correlate with their metastatic propensity. A number of these signatures have been deployed in the clinic as risk stratification tools. However, the molecular basis of these clinically useful prognostic signatures has remained a largely unresolved area of ...
Anita Wolfer, Sridhar Ramaswamy
openaire +3 more sources
Anti-S100A4 Antibody Suppresses Metastasis Formation by Blocking Stroma Cell Invasion
The small Ca-binding protein, S100A4, has a well-established metastasis-promoting activity. Moreover, its expression is tightly correlated with poor prognosis in patients with numerous types of cancer.
Jörg Klingelhöfer+6 more
doaj +1 more source
L1-regularized neural ranking for risk stratification and its application to prediction of time to distant metastasis in luminal node negative chemotherapy naïve breast cancer patients [PDF]
Can we predict if an early stage cancer patient is at high risk of developing distant metastasis and what clinicopathological factors are associated with such a risk? In this paper, we propose a ranking based censoring-aware machine learning model for answering such questions.
arxiv
Symptomatic CNS Radiation Necrosis Requiring Neurosurgical Resection During Treatment with Lorlatinib in ALK-Rearranged NSCLC: A Report of Two Cases. [PDF]
Central nervous system (CNS) metastasis carries a significant morbidity and mortality in anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC).
Al-Holou, Wajd+7 more
core +1 more source
Cancer is one of the most life threatening diseases afflicting mankind. Oral carcinogenesis is a multifactorial process involving numerous genetic events that alter normal functions of oncogenes and tumour suppressor genes. These changes lead to a cell phenotype with increased cell proliferation, with loss of cell cohesion, and infiltration of adjacent
Pallavi Shirol+3 more
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Objective: The expression of B-cell lymphoma 2 (Bcl-2) seems to be influenced by the endocrine environment. Numerous reports demonstrate the diverse expression of Bcl-2 family members under sex steroid regulation.
Xiao-Fei Zhang+16 more
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Bone metastasis pattern of cancer patients with bone metastasis but no visceral metastasis
Bone metastasis of cancer can be a result from systemic blood spreading or vertebral venous plexus spreading. Systemic blood pathway induced bone metastasis can happen in any bone in the body since the spreading is considered to be random. However, it remains unknown whether there is any pattern of vertebral venous plexus related bone metastasis.
Mingyu Zhu+16 more
openaire +3 more sources
PKM2 Drives Hepatocellular Carcinoma Progression by Inducing Immunosuppressive Microenvironment
Background and AimsPyruvate kinase M2 (PKM2) is an essential regulator of the Warburg effect, but its biological function promoting immune escape of hepatocellular carcinoma (HCC) is unclear.MethodsGEPIA web tool and immunohistochemistry (IHC) analysis ...
Tian-En Li+14 more
doaj +1 more source