Results 121 to 130 of about 291,831 (295)
Solving the Amyloid Paradox: Unveiling the Complex Pathogenicity of Amyloid Fibrils
Aggregate, EarlyView.This review addresses the gap between strong evidence for the involvement of amyloid fibrils in neurodegeneration and the failure of anti‐amyloid therapies, a phenomenon herein termed the “amyloid paradox.” To address this paradox, we provide a comprehensive summary of the current understanding of fibrils' pathogenic properties and mechanisms ...
Maksim I. Sulatsky +3 more
wiley +1 more source
Angewandte Chemie, EarlyView.Malleicyprol, a virulence factor of notorious animal and human pathogens of the Burkholderia pseudomallei (BP) group, results from the fusion of two individual polyketide chains. The noncanonical condensation domain of the PKS–NRPS hybrid synthetase BurF forms an ester bond, and the terminal reductase domain mediates a reductive chain release followed ...
Jonas Fiedler +5 more
wiley +2 more sources
Journal of Applied Poultry Research, 2019 SUMMARY: High-quality protein feeds are needed in ecological and organic poultry production. Feeds that are rich in methionine (MET) are particularly important because synthetic amino acids are generally prohibited in organic livestock production ...
I. Upadhyaya +13 more
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Autonomous Navigation of Bio‐Intelligent Cyborg Insect Based on Insect Visual Perception
Advanced Intelligent Systems, EarlyView.The bio‐intelligent cyborg insect (BCI) introduces a noninvasive ultraviolet‐based control method, leveraging natural sensory behaviors for adaptive navigation. By integrating biological and artificial intelligence, BCI minimizes habituation and enhances locomotion in complex environments.
Chowdhury Mohammad Masum Refat +4 more
wiley +1 more source
Genetics of Response to ECT, TMS, Ketamine and Esketamine
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT Treatment‐resistant mood disorders are often managed with intensive interventions that include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), ketamine, and esketamine, but the role of genetics in clinical response to those interventions is yet to be clearly determined.
Clio E. Franklin +18 more
wiley +1 more source
Metabolic alterations in human pulmonary artery smooth muscle cells treated with PDGF‐BB
Animal Models and Experimental Medicine, EarlyView.Metabolic abnormalities are considered to play a key regulatory role in vascular remodeling of pulmonary arterial hypertension. We analyzed the metabolome in the culture supernatants of human pulmonary artery smooth muscle cells (PASMC) during the malignant proliferation phenotype transition via a targeted metabolomics method. Significant and extensive
Meng‐Jie Zhang +9 more
wiley +1 more source
Cerebrospinal Fluid Metabolome in Central Nervous System Infections: A Study of Diagnostic Accuracy
Annals of Neurology, EarlyView.Objective To assess the diagnostic accuracy of metabolites in cerebrospinal fluid (CSF) for central nervous system (CNS) infections. Methods Patients were derived from three prospective cohort studies in the Netherlands. All studies included adults suspected of a CNS infection who underwent a diagnostic lumbar puncture.
Steven L. Staal +7 more
wiley +1 more source
STUDIES IN METHIONINE AND SULFUR METABOLISM. I. THE FATE OF INTRAVENOUSLY ADMINISTERED METHIONINE, IN NORMAL INDIVIDUALS AND IN PATIENTS WITH LIVER DAMAGE 12 [PDF]
, 1948 Laurance W. Kinsell +4 more
openalex +1 more source