Results 121 to 130 of about 524,170 (287)

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Chunggan extract (CGX), methionine-and choline-deficient (MCD) diet-induced hepatosteatosis and oxidative stress in C57BL/6 mice [PDF]

, 2013
Hyun Jung Park, J-M Han, H-G Kim, M. S. Choi, JS Lee, Hye Won Lee, C-G Son   +6 more
openalex   +1 more source

The effect of feeding adequate or deficient vitamin B6 or folic acid to breeders on methionine metabolism in 18-day-old chick embryos

, 2021
Jianwei Lu, Jordan Weil, P. Maharjan, M.K. Manangi, S. Cerrate, C.N. Coon   +5 more
openalex   +1 more source

Inhibition of HDACs (Histone Deacetylases) Ameliorates High-Fat Diet–Induced Hypertension Through Restoration of the MsrA (Methionine Sulfoxide Reductase A)/Hydrogen Sulfide Axis [PDF]

, 2021
Jin Ki Jung, Ga-Eun Yoon, GiBong Jang, Kwon Moo Park, Inkyeom Kim, Jee In Kim   +5 more
openalex   +1 more source

Discovery of a Potent and Selective TEAD Degrader with Durable Degradation Activity

Advanced Science, EarlyView.
KG‐FP‐003, a highly potent TEAD‐YAP PROTAC derived from the patented inhibitor is developed. It selectively degrades endogenous TEAD proteins in HiBiT systems without IMiD‐related off‐target effects. Screening across 867 cancer cell lines revealed broad and superior anti‐tumor activity, highlighting its therapeutic potential through targeted TEAD ...
Linhui Cao, Jing Yang, Yuhang Liu, Xiaotong Chen, Yufang Shi, Yunshuo Zhao, Yong Zhang, Jian Chen, Bowen Li, Wuqiang Wen, Lu Chen, Bo Peng, Lu Huang, Yanli Sun, Lixin Zhou, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Zhixiang Guo, Jing Xing, Guangya Zhu, Yazhou Wang, Baishan Jiang, Jing Lu, Kehao Zhao, Wenchao Lu   +25 more
wiley   +1 more source

Multi-criteria assessment of pea protein quality in rats: a comparison between casein, gluten and pea protein alone or supplemented with methionine

, 2020
Florence Guillin, Claire Gaudichon, Laetitia Guérin‐Deremaux, Catherine Lefranc‐Millot, Dalila Azzout‐Marniche, Nadezda Khodorova, Juliane Calvez   +6 more
openalex   +2 more sources

A Facile Method for the Separation of Methionine Sulfoxide Diastereomers, Structural Assignment, and DFT Analysis [PDF]

, 2019
Jevgenij A. Raskatov, Scott C. Virgil, Hsiau‐Wei Lee, Lawrence M. Henling, Ka Chan, Ariel J. Kuhn, Alejandro R. Foley   +6 more
openalex   +1 more source

Deacetylation of ACLY Mediates RNA M6A‐Modification of NOXA and Promotes Chemoresistance of Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the deacetylation of ACLY at K978 acts as a novel risk in colorectal cancer chemoresistance. The deacetylation of K978 induces ACLY relocation to the nucleus and promotes its binding to RBM15, a m6A methylation modification “writer”.
Jun Wen, Mengqin Shen, Haitao Zhao, Liu Liu, Qian Hua, Xiaoping Zhao, Jianjun Liu, Haizhong Feng, Gang Huang   +8 more
wiley   +1 more source

Impact of dietary changes on hepatic homocysteine metabolism in young broilers [PDF]

, 2004
Information regarding the impact of sulfur amino acids (SAA) on hepatic homocysteine (Hcy) flux through the various metabolic pathways competing for Hcy in young broilers is lacking. An experiment was conducted to evaluate the impact of varying levels of
Emmert, Jason L., Ganson, Fauna M., Pillai, Padmakumar   +2 more
core   +2 more sources

Methionine Induces Sexual Development in the Fission Yeast Schizosaccharomyces pombe via an ste11 -Dependent Signalling Pathway [PDF]

, 1998
Anne‐Marie Schweingruber, Norma Hilti, Eleonore Edenharter, M. Ernst Schweingruber   +3 more
openalex   +1 more source