Results 21 to 30 of about 607,306 (389)

Methionine deficiency facilitates antitumour immunity by altering m6A methylation of immune checkpoint transcripts

Gut, 2022
Objective Methionine metabolism is involved in a myriad of cellular functions, including methylation reactions and redox maintenance. Nevertheless, it remains unclear whether methionine metabolism, RNA methylation and antitumour immunity are molecularly ...
Ting Li, Yue Tan, Yanxing Chen, Xiaojun Zheng, Wen Wang, Kun Liao, Hai-Yu Mo, Junzhong Lin, Wei Yang, Hai-long Piao, Ruifeng Xu, Huai-qiang Ju   +11 more
semanticscholar   +1 more source

Ndufaf2, a protein in mitochondrial complex I, interacts in vivo with methionine sulfoxide reductases

Redox Report, 2023
Background Methionine sulfoxide reductases are found in all aerobic organisms. They function in antioxidant defense, cellular regulation by reversible oxidation of methionine in proteins, and in protein structure.
Sujin Park, José A. Trujillo-Hernandez, Rodney L. Levine   +2 more
doaj   +1 more source

Cystathionine beta synthase deficiency and brain edema associated with methionine excess under betaine supplementation: Four new cases and a review of the evidence. [PDF]

, 2020
CBS deficient individuals undergoing betaine supplementation without sufficient dietary methionine restriction can develop severe hypermethioninemia and brain edema. Brain edema has also been observed in individuals with severe hypermethioninemia without
Barea, Jaime J, Barshop, Bruce A, Benoist, Jean-Francois, Blom, Henk J, Das, Anibh M, Feigenbaum, Annette, Fletcher, Janice, Scheffner, Thomas, Schwahn, Bernd C, Stepman, Hedwig, Verloo, Peter   +10 more
core   +1 more source

Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma

Nature Communications, 2021
T-cell exhaustion denotes a hypofunctional state of T lymphocytes commonly found in cancer, but how tumor cells drive T-cell exhaustion remains elusive.
M. Hung, J. Lee, Chi Ma, L. Diggs, S. Heinrich, C. Chang, Lichun Ma, M. Forgues, A. Budhu, Jittiporn Chaisaingmongkol, M. Ruchirawat, E. Ruppin, T. Greten, X. Wang   +13 more
semanticscholar   +1 more source

4006 Methionine Dependence in Cancer: From Metabolic Phenotype to Therapy

Journal of Clinical and Translational Science, 2020
OBJECTIVES/GOALS: Methionine dependence was described 45 years ago as an increased reliance on an exogenous supply of the essential amino acid methionine in most cancer cells compared to normal cells. Methionine depletion, using either synthetic diets or
Isabelle Miousse
doaj   +1 more source

Serum Lipid, Amino Acid and Acylcarnitine Profiles of Obese Cats Supplemented with Dietary Choline and Fed to Maintenance Energy Requirements

Animals, 2021
Obesity is a health concern for domestic cats. Obesity and severe energy restriction predispose cats to feline hepatic lipidosis. As choline is linked to lipid metabolism, we hypothesized that dietary choline supplementation would assist in reducing ...
Adronie Verbrugghe, Alexandra Rankovic, Shafeeq Armstrong, Amanda Santarossa, Gordon M. Kirby, Marica Bakovic   +5 more
doaj   +1 more source

Disposable Electrochemical Sensor for Food Colorants Detection by Reduced Graphene Oxide and Methionine Film Modified Screen Printed Carbon Electrode

Molecules, 2021
A facile synthesis of reduced graphene oxide (rGO) and methionine film modified screen printed carbon electrode (rGO-methionine/SPCE) was proposed as a disposable sensor for determination of food colorants including amaranth, tartrazine, sunset yellow ...
Chutimon Akkapinyo, Kittitat Subannajui, Yingyot Poo-arporn, Rungtiva P. Poo-arporn   +3 more
doaj   +1 more source

Tunable, Functional Diblock Copolypeptide Hydrogels Based on Methionine Homologs. [PDF]

, 2020
The preparation of new diblock copolypeptide hydrogels derived from homologs of l-methionine, that is, l-homomethionine and l-6-(methylthio)-l-norleucine is described.
Deming, Timothy J, Gharakhanian, Eric G, Negri, Graciela E   +2 more
core   +1 more source

Cancer SLC43A2 alters T cell methionine metabolism and histone methylation

Nature, 2020
Abnormal epigenetic patterns correlate with effector T cell malfunction in tumours1–4, but the cause of this link is unknown. Here we show that tumour cells disrupt methionine metabolism in CD8+ T cells, thereby lowering intracellular levels of ...
Yingjie Bian, Wei Li, Daniel M. Kremer, Peter Sajjakulnukit, Shasha Li, Joel Crespo, Z. Nwosu, Li Zhang, A. Czerwonka, A. Pawlowska, Houjun Xia, Jing Li, P. Liao, Jiali Yu, Linda Vatan, Wojciech Szeliga, Shuang Wei, Sara Grove, J. Liu, K. McLean, M. Cieslik, A. Chinnaiyan, W. Zgodziński, G. Wallner, I. Wertel, K. Okła, Ilona Kryczek, C. Lyssiotis, W. Zou   +28 more
semanticscholar   +1 more source

The Level of Methionine Residues in Storage Proteins Is the Main Limiting Factor of Protein-Bound-Methionine Accumulation in Arabidopsis Seeds

Frontiers in Plant Science, 2020
The low level of methionine, an essential sulfur-containing amino acid, limits the nutritional quality of seeds. Two main factors can control the level of protein-bound methionine: the level of free methionine that limits protein accumulation and the ...
Aiswarya Girija, David Shotan, David Shotan, Yael Hacham, Yael Hacham, Rachel Amir, Rachel Amir   +6 more
doaj   +1 more source