Results 1 to 10 of about 3,813 (143)

Implications of divergence of methionine adenosyltransferase in archaea [PDF]

FEBS Open Bio, 2022
Methionine adenosyltransferase (MAT) catalyzes the biosynthesis of S‐adenosyl methionine from l‐methionine and ATP. MAT enzymes are ancient, believed to share a common ancestor, and are highly conserved in all three domains of life.
Bhanu Pratap Singh Chouhan, Madhuri Gade, Desirae Martinez, Saacnicteh Toledo‐Patino, Paola Laurino   +4 more
doaj   +5 more sources

Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis [PDF]

Nature Communications, 2022
High methionine and S-adenosylmethionine serum levels are related with obesity. Here the authors show that knockdown of methionine adenosyltransferase by using antisense oligonucleotides provides beneficial effects in obesity and comorbidities.
Diego Sáenz de Urturi, Xabier Buqué, Begoña Porteiro, Cintia Folgueira, Alfonso Mora, Teresa C. Delgado, Endika Prieto-Fernández, Paula Olaizola, Beatriz Gómez-Santos, Maider Apodaka-Biguri, Francisco González-Romero, Ane Nieva-Zuluaga, Mikel Ruiz de Gauna, Naroa Goikoetxea-Usandizaga, Juan Luis García-Rodríguez, Virginia Gutierrez de Juan, Igor Aurrekoetxea, Valle Montalvo-Romeral, Eva M. Novoa, Idoia Martín-Guerrero, Marta Varela-Rey, Sanjay Bhanot, Richard Lee, Jesus M. Banales, Wing-Kin Syn, Guadalupe Sabio, María L. Martínez-Chantar, Rubén Nogueiras, Patricia Aspichueta   +28 more
doaj   +2 more sources

Long-term prognosis of 35 patients with methionine adenosyltransferase deficiency based on newborn screening in China [PDF]

Frontiers in Cell and Developmental Biology, 2023
Methionine adenosyltransferase deficiency (MATD) is a rare metabolic disorder caused by mono- or biallelic MAT1A mutations that are not yet well understood.
Fan Tong, Yuchen Zhang, Yuchen Zhang, Chi Chen, Ling Zhu, Yijun Lu, Yijun Lu, Zhanming Zhang, Ting Chen, Jiaxuan Yan, Jing Zheng, Xiaoxu Zhao, Duo Zhou, Xin Yang, Rulai Yang, Xiaohui Cang, Xiaohui Cang, Pingping Jiang, Pingping Jiang, Qiang Shu, Qiang Shu   +20 more
doaj   +2 more sources

Hypermethioninemia due to methionine adenosyltransferase I/III deficiency and brain damage [PDF]

BMC Pediatrics
Background and objectives Methionine adenosyltransferase I/III deficiency used to be considered a relatively benign disease. This study aims to elucidate the clinical characteristics of methionine adenosyltransferase I/III deficiency patients with ...
Xue Ma, Mei Lu, Zhehui Chen, Huiting Zhang, Jinqing Song, Hui Dong, Ying Jin, Mengqiu Li, Ruxuan He, Lulu Kang, Yi Liu, Yongxing Chen, Zhijun Zhu, Liying Sun, Yao Zhang, Yanling Yang   +15 more
doaj   +2 more sources

Methionine Adenosyltransferase 1A and S-Adenosylmethionine in Alcohol-Associated Liver Disease [PDF]

Antioxidants
Alcohol-associated liver disease (ALD) is a leading cause of liver-related morbidity, mortality, and premature death worldwide. Its pathogenesis is complex and incompletely understood, with disrupted methionine metabolism as a key contributor.
Lucía Barbier-Torres, Jyoti Chhimwal, José M. Mato, Shelly C. Lu   +3 more
doaj   +2 more sources

Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease [PDF]

Nature Communications, 2022
Lower activity of MATα1, which catalyzes the synthesis of the methyl donor S-adenosylmethionine, and mitochondrial dysfunction occur in alcohol-associated liver disease (ALD).
Lucía Barbier-Torres, Ben Murray, Jin Won Yang, Jiaohong Wang, Michitaka Matsuda, Aaron Robinson, Aleksandra Binek, Wei Fan, David Fernández-Ramos, Fernando Lopitz-Otsoa, Maria Luque-Urbano, Oscar Millet, Nirmala Mavila, Hui Peng, Komal Ramani, Roberta Gottlieb, Zhaoli Sun, Suthat Liangpunsakul, Ekihiro Seki, Jennifer E. Van Eyk, Jose M. Mato, Shelly C. Lu   +21 more
doaj   +2 more sources

Discovery of Potential Scaffolds for Methionine Adenosyltransferase 2A (MAT2A) Inhibitors: Virtual Screening, Synthesis, and Biological Evaluation [PDF]

Molecules
The inhibition of methionine adenosyltransferase 2A (MAT2A) in cancers harboring deletions of the methylthioadenosine phosphorylase (MTAP) gene induces synthetic lethality, making it a highly compelling strategy in the pursuit of precision anticancer ...
Chunchun Qi, Xinghui Yu, Siyu Zuo, Pinsheng Han, Ruonan An, Yamin Zhang   +5 more
doaj   +2 more sources

Mechanism and Inhibition of Human Methionine Adenosyltransferase 2A. [PDF]

Biochemistry, 2021
S-Adenosyl-l-methionine (AdoMet) is synthesized by the MAT2A isozyme of methionine adenosyltransferase in most human tissues and in cancers. Its contribution to epigenetic control has made it a target for anticancer intervention. A recent kinetic isotope effect analysis of MAT2A demonstrated a loose nucleophilic transition state.
Niland CN, Ghosh A, Cahill SM, Schramm VL.   +3 more
europepmc   +3 more sources

Methionine Adenosyltransferase I/III Deficiency Detected by Newborn Screening. [PDF]

Genes (Basel), 2022
Methionine adenosyltransferase I/III deficiency is an inborn error of metabolism due to mutations in the MAT1A gene. It is the most common cause of hypermethioninemia in newborn screening. Heterozygotes are often asymptomatic. In contrast, homozygous or compound heterozygous individuals can develop severe neurological symptoms.
Hübner V, Hannibal L, Janzen N, Grünert SC, Freisinger P.   +4 more
europepmc   +4 more sources

A novel role of secreted methionine adenosyltransferase α2 in colorectal liver metastases [PDF]

Journal of Experimental & Clinical Cancer Research
Background Colorectal liver metastasis (CRLM) occurs frequently in patients with colorectal cancer (CRC). Methionine adenosyltransferase (MAT) catalyzes the formation of S-adenosylmethionine, the principal methyl donor. MAT1A (encodes MATα1) is expressed
Monica Justo, Youngyi Lim, Heping Yang, Andrea Floris, Swati Chandla, Manisha Dagar, Alexandra Gangi, Edwin Posadas, Mouad Edderkaoui, Stephen Pandol, Neil Bhowmick, Maria Lauda Tomasi, Shelly C. Lu   +12 more
doaj   +2 more sources