Results 51 to 60 of about 107,753 (225)
New analogues of leucine-methionine-enkephalin
Journal of Biosciences, 1988 Nine analogues of the opioid pentapeptides leucine-/ methionine-enkephalinamide, involving replacement of amino acid at position 5 or amino acids at positions 2 and 5, have been synthesized by the solid phase method using mainly 9-fluorenylmethyloxycarbonyl amino acid trichlorophenyl esters in the presence of 1-hydroxybenzotriazole, the solid support ...
Sivanandaiah, K.M. +2 more
openaire +3 more sources
Annals of Hepatology, 2008 Endogenous opioids participate in growth regulation. Liver regeneration relates to growth. Thus, we explored the expression of methionine enkephalin and of the delta opioid receptor 1 immunoreactivities with a polyclonal rabbit antibody in deparaffinized
Vijaya D. Boyella +2 more
doaj
Molecular Nutrition &Food Research, EarlyView.Resveratrol and pterostilbene reduced the steatotic status of animals fed a high‐fat, high‐sucrose diet, involving differential and specific mechanisms of action for each stilbene. Thus, changes in riboflavin metabolism, nicotinamide mononucleotide metabolism, or in the LysoPC(18:1)‐mediated effects contribute to the specific actions of pterostilbene ...
Alfredo Fernández‐Quintela +5 more
wiley +1 more source
Comparative Study of Multicanonical and Simulated Annealing Algorithms in the Protein Folding Problem [PDF]
, 1994 We compare a few variants of the recently proposed multicanonical method with the well known simulated annealing for the effectiveness in search of the energy global minimum of a biomolecular system. For this we study in detail Met-enkephalin, one of the simplest peptides.
arxiv +1 more source
Applied Research, Volume 4, Issue 3, June 2025.The development of a nanobody for Nogo‐A, a potent neurite outgrowth inhibitor crucial in multiple sclerosis, is reported using a rational design approach. The nanobody targets the Nogo‐A ectodomain at the S1PR2 receptor‐binding region with submicromolar KD.
Vaidehi Roy Chowdhury +9 more
wiley +1 more source
Aquaculture Reports, 2020 The involvement of endogenous opioid peptides in regulation of reproductive activity is implicated in a majority of vertebrates. Methionine-enkephalin (M-ENK) is an endogenous opioid peptide neurotransmitter produced in the central nervous system ...
C.B. Ganesh, Vijayalaxmi
doaj
N‐ to C‐Peptide Synthesis, Arguably the Future for Sustainable Production
Journal of Peptide Science, Volume 31, Issue 6, June 2025.The advent of epimerization‐free methods for coupling in N‐ to C‐direction synthesis offers improved atom economy for sustainable peptide synthesis. ABSTRACT A revolution in peptide production arrived from the innovation of carboxylate to amine C‐ to N‐direction solid‐phase synthesis.
Kinshuk Ghosh, William D. Lubell
wiley +1 more source
Biased Metropolis Sampling for Rugged Free Energy Landscapes [PDF]
AIP Conference Proceedings Vol.690, 63-73 (2003), 2003 Metropolis simulations of all-atom models of peptides (i.e. small proteins) are considered. Inspired by the funnel picture of Bryngelson and Wolyness, a transformation of the updating probabilities of the dihedral angles is defined, which uses probability densities from a higher temperature to improve the algorithmic performance at a lower temperature.
arxiv +1 more source
Kinetics of chymotrypsin- and papain-catalysed synthesis of [leucine]enkephalin and [methionine]enkephalin [PDF]
Biochemical Journal, 1984 The proteinase-catalysed synthesis of [Leu]enkephalin and [Met]enkephalin was studied kinetically. N alpha-t-Butoxycarbonyl-amino acids and peptides or their ethyl esters served as acyl donors, and amino acid phenylhydrazides were used as acyl acceptors.
openaire +3 more sources
Aging Cell, Volume 24, Issue 3, March 2025.The study identified dysregulated fatty acid metabolism and inflammation as contributors to physio‐cognitive decline syndrome (PCDS). Sex‐specific metabolic disruptions were noted, with altered central carbon and tyrosine metabolism more pronounced in men and glutathione pathway perturbations more evident in women.
Yi‐Long Huang +7 more
wiley +1 more source