Results 91 to 100 of about 81,363 (150)

Acid‐Stable Nitrofuran Triple Therapy With Rabeprazole and Amoxicillin Targeting Helicobacter pylori Infection

MedComm, Volume 7, Issue 10, October 2026.
Overview: Novel nitrofuran derivatives were developed and evaluated against Helicobacter pylori to overcome antibiotic resistance and inflammation. Methods and Findings: In vitro assays using H. pylori 60190 and PMSS1 strains demonstrated potent antibacterial activity, reduced bacterial adhesion, and inhibited cytokine release from gastric epithelial ...
Nagendran Tharmalingam, Kulandaisamy Arulsamy, Shaolei Lu, Sadhna Dhingra, Scott Goodrich, Joseph St Laurent, Gerald Jones, Eleftherios Mylonakis   +7 more
wiley   +1 more source

Metabolomics Based Biomarkers of Green Beans Intake

Molecular Nutrition &Food Research, Volume 70, Issue 19, 15 October 2026.
Identification of urinary food intake biomarkers of green beans using metabolomics applied to time response and dose response studies.This image was created with BioRender.com. ABSTRACT While there is considerable interest in legumes as a food source, there are no validated biomarkers for green beans (Phaseolus vulgaris, L.) intake.
Rebecca Finlay, Ya Gao, Qi Sun, Frank Hu, Jayne Woodside, Xiaofei Yin, Lorraine Brennan   +6 more
wiley   +1 more source

EvoMut: A computational framework for engineering oxidative stability in proteins

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Amino acid oxidation is a major cause of protein instability and loss of function in therapeutic and industrial settings. Although methionine, cysteine, tryptophan, tyrosine, histidine, lysine, and arginine residues are widely recognized as oxidation‐prone, only a subset of such residues is dominant functional hotspots, and not all are ...
Seyed Shahriar Arab, Chenlin Hsieh, Nathan E. Lewis   +2 more
wiley   +1 more source

The assembly of tetrameric human L‐lactate dehydrogenase is regulated by ionic strength, β‐NADH binding, cyclic peptides, and long‐chain dicarboxylates

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Lactate dehydrogenases catalyze the reduction of pyruvate to lactate, the generation of which is of importance for the energetic metabolism of malignant cells. In particular, human cancer cells overexpress lactate dehydrogenase A (hLDH‐A), whose catalytic activity depends on its assembly into the corresponding homotetramer (denoted as hLDH‐5),
Alessandra Stefan, Luca Gentilucci, Alberto Giuseppe Barbiroli, Valentina Rossi, Hang Liao, Giuseppina Di Stefano, Tingting He, Alejandro Hochkoeppler   +7 more
wiley   +1 more source

β‐Caryophyllene Mitigates Thioacetamide‐Induced Liver Fibrosis Through CB2‐Mediated Suppression of Necroptosis: A Therapeutic Investigation

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
β‐Caryophyllene is a multifunctional sesquiterpene with significant therapeutic potential. Our findings demonstrate that β‐caryophyllene exerts broad hepatoprotective effects through the activation of cannabinoid type 2 (CB2) receptors. These effects include suppression of oxidative stress–induced injury, attenuation of inflammatory responses ...
Lujain Bader Eddin, Seenipandi Arunachalam, Loay Lubbad, Fayez T. Hammad, Ernest Adeghate, Sandeep Subramanya, Shreesh Ojha   +6 more
wiley   +1 more source

Sequence Inversion Dictates the Antiproliferative Activity of Bidirectional Tryptophan‐Containing Dipeptide Libraries

Journal of Peptide Science, Volume 32, Issue 10, October 2026.
Reversing the peptide backbone sequence of novel tryptophyl‐dipeptides uncovers profound changes in synthetic accessibility and antineoplastic profiles against human solid tumors. Phenotypic screening identifies a conformationally restricted lead architecture that achieves sub‐micromolar growth inhibition, confirming sequence topology as a critical ...
J. Benamer Díaz, Adam N. Khan, Aday González‐Bakker, José M. Padrón   +3 more
wiley   +1 more source

Role of Schizosaccharomyces pombe Methionine Sulfoxide Reductase (msr) Genes in Oxidative Stress Resistance [PDF]

, 2005
Thesis advisor: Clare O'ConnorAs organisms get older, the proteins in their cells also age, and as this happens, the amino acids that make up these proteins may become chemically modified and begin to lose their integrity.
DeFoer, Heather Elaine
core  

Inhibition of leucine‐rich kinase 2 (LRRK2) promotes peripheral axon regeneration via phosphorylation‐network remodelling

British Journal of Pharmacology, Volume 183, Issue 20, Page 6199-6224, October 2026.
Background and Purpose In contrast to neurons in the central nervous system, neurons in the peripheral nervous system can regenerate axons after injury via activation of a pro‐regenerative transcriptional programme. Pathogenic mutations in leucine‐rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, and several small ...
Eun‐Hae Jang, Eun Mo Yang, Gil Song, Seung Min Park, Harryn Choi, Jaeyong Kim, Chanil Kim, Yunho Gim, Hyuk‐Joo Jeon, Yewon Cho, Jong Bae Park, Eun‐Mi Hur   +11 more
wiley   +1 more source

A cross‐species post‐translational modification profiling of histones by LC‐MS/MS revealed conserved oxidative modifications in plants

New Phytologist, Volume 252, Issue 2, Page 538-545, October 2026.
Conservation of post‐translational modifications (PTMs) in histones across six plant species.
Sau‐Shan Cheng, Wai‐Ching Sin, Yuen‐Yi Chau, Hon‐Ming Lam   +3 more
wiley   +1 more source

Studies of Methionine Sulfoxide. I. The Acidic Degradation of Methionine Sulfoxide [PDF]

Bulletin of the Chemical Society of Japan, 1964
openaire   +1 more source