Results 71 to 80 of about 81,363 (150)

Monitoring methionine sulfoxide with stereospecific mechanism-based fluorescent sensors [PDF]

, 2015
Methionine can be reversibly oxidized to methionine sulfoxide (MetO) under physiological and pathophysiological conditions, but its use as a redox marker suffers from the lack of tools to detect and quantify MetO within cells.
Lionel Tarrago, Gladyshev, Vadim, Vadim N Gladyshev, Tarrago, Lionel, Michel, Thomas, Thomas Michel, Lee, Byung Cheon, Byung Cheon Lee, Zalán Péterfi, Péterfi, Zalán   +9 more
core   +1 more source

Methionine Regulates Antitumour Function of CD8+ T Cells Through Polyamine Synthesis

Immunology, Volume 179, Issue 3, Page 418-433, November 2026.
Methionine restriction in vitro enhances CD8+ T cell effector function by suppressing polyamine synthesis and progressively induces the co‐expression of PD‐1 and TIM‐3. Consistently, sustained dietary methionine restriction diminishes the efficacy of adoptive T cell therapy (ACT) and promotes the expression of terminal exhaustion‐associated markers ...
Tian Zhao, Gillian A. Carleton, Sam Preshaw, Sarah MacPherson, Madison Shiyuk, Joseph Monaghan, Jun Han, Oro Uchenunu, Robert Rottapel, Ralph J. DeBerardinis, Kelly M. Stewart, Bo‐Hyun Kim, Juan Ausió, David R. Goodlett, Helena Pětrošová, Kyle D. Duncan, Julian J. Lum   +16 more
wiley   +1 more source

Methionine-Oxidized Amyloid Fibrils Are Poor Substrates for Human Methionine Sulfoxide Reductases A and B2

, 2016
A common feature of many amyloid diseases is the appearance of oxidized, aggregated proteins. Methionine is one of the most readily oxidized amino acids, and its oxidative state is regulated in vivo by the methionine sulfoxide reductases (Msr).
Geoffrey J. Howlett (306998), Stefan H. Heinemann (1446607), Michael D. W. Griffin (152802), Katrina J. Binger (2306401)   +3 more
core   +1 more source

In Vitro Selection of Aptamers for Methionine Sulfoxide [PDF]

, 2022
Oxidation of methionine to methionine sulfoxide in proteins is considered one of important post-translational modifications of proteins. This modification can activate and also inhibit functions of many proteins and it is a part of regulation mechanisms ...
Jureček, Matěj
core  

Drought and salinity stress remodel Asian rice (Oryza sativa) leaf development through cell‐type‐specific regulatory programs

New Phytologist, Volume 252, Issue 4, Page 1376-1395, November 2026.
Osmotic stressors induce developmental and physiological changes in rice (Oryza sativa) seedlings, which are modulated by cell‐type‐specific gene expression and regulatory networks. We exposed plants to two levels of drought and salinity stress and measured the effects of these stressors on developing leaves by measuring physiological traits, ion ...
Sean M. Robertson, Obaid Maqsood, Chi Dang, Asher Pasha, Claudio Stasolla, Nicholas J. Provart, Olivia Wilkins   +6 more
wiley   +1 more source

Novel Amino Acid Changes Increase Phosphoenolpyruvate Carboxylase Output in planta

Plant, Cell &Environment, Volume 49, Issue 11, Page 8306-8321, November 2026.
ABSTRACT Characterization of previously reported Arabidopsis mutants with increased aluminum (Al) resistance (alr) resulting from greater release of Al‐chelating malate identified three unique amino acid substitutions that each impacts PHOSPHOENOLPYRUVATE CARBOXYLASE 1, a key anaplerotic carbon fixation enzyme.
Jinrui Sheng, Kevin Frausto, Sarah Haesaerts, Taylor J. Meyer, Maruša Prolič‐Kalinšek, Seán E. O'Leary, Remy Loris, Paul B. Larsen   +7 more
wiley   +1 more source

Overexpression of Methionine-\u3ci\u3eR\u3c/i\u3e-Sulfoxide Reductases Has No Influence on Fruit Fly Aging [PDF]

, 2009
Methionine sulfoxide reductases (Msrs) are enzymes that repair oxidized methionine residues in proteins. This function implicated Msrs in antiox¬idant defense and the regulation of aging.
Kabil, Hadise, Shchedrina, Valentina A., Lee, Byung Cheon, Harshman, Lawrence G., Gladyshev, Vadim N., Vorbrüggen, Gerd, Kim, Hwa-Young   +6 more
core  

Functional analysis of free methionine-R-sulfoxide reductase from saccharomyces cerevisiae

, 2009
Methionine sulfoxide reductases (Msrs) are oxidoreductases that catalyze thiol-dependent reduction of oxidized methionines. MsrA and MsrB are the best known Msrs that repair methionine S-sulfoxide (Met-S-SO) and methionine-R-sulfoxide (Met-R-SO) residues
Hacıoğlu, Elise, Kwak, Geun-Hee, Marino, Stefano M., Fomenko, Dmitri E., Zhang, Yan, Le, Dung Tien, Lee, Byung Cheon, Gladyshev, Vadim N., Kaya, Alaattin, Kim, Hwa-Young, Koç, Ahmet, 10. Kim, Hwa-Young, 9. Koç, Ahmet, 7. Hacıoğlu, Elise, 11. Gladyshev, Vadim N., 6. Kaya, Alaattin, 4. Zhang, Yan, 8. Kwak, Geun-Hee, 3. Marino, Stefano M., 1. Le, Dung Tien, 5. Fomenko, Dmitri E., 2. Lee, Byung Cheon   +21 more
core   +1 more source

Decreased Phosphorylation and Increased Methionine Oxidation of α-Synuclein in the Methionine Sulfoxide Reductase A Knockout Mouse [PDF]

, 2011
Previously, we have showed that overexpression of methionine-oxidized α-synuclein in methionine sulfoxide reductase A (MsrA) null mutant yeast cells inhibits α-synuclein
Jackob Moskovitz, Derek B. Oien, Gonzalo A. Carrasco   +2 more
core   +1 more source

Selective N‐Functionalization of Pyrazoles

European Journal of Organic Chemistry, Volume 29, Issue 40, 27 October 2026.
This review traces the evolution of regioselective N‐functionalization strategies for pyrazoles, a key class of nitrogen heterocycles widely used in medicinal chemistry. Due to rapid tautomerism, N‐functionalization often lacks selectivity, leading to poor and unpredictable regioisomeric outcomes.
Lucas Popek, Matthias Schrader, Christopher J. Teskey   +2 more
wiley   +1 more source