Results 51 to 60 of about 81,363 (150)

Methionine Residues in Exoproteins and Their Recycling by Methionine Sulfoxide Reductase AB Serve as an Antioxidant Strategy in Bacillus cereus [PDF]

, 2017
During aerobic respiratory growth, Bacillus cereus is exposed to continuously reactive oxidant, produced by partially reduced forms of molecular oxygen, known as reactive oxygen species (ROS).
Madeira, Jean-Paul, Alpha-Bazin, Béatrice M., Armengaud, Jean   +2 more
core   +2 more sources

Induction of methionine-sulfoxide reductases protects neurons from amyloid β-protein insults in vitro and in vivo [PDF]

, 2011
Amyloid β-protein (Aβ) self-assembly into toxic oligomers and fibrillar polymers is believed to cause Alzheimer’s disease (AD). In the AD brain, a high percentage of Aβ contains Met-sulfoxide at position 35, though the role this modification plays in AD ...
Attar, Aida, Dahabada H. J. Lopes, Mittal, Shivina, Shivina Mittal, Jane Hayes, Jackob Moskovitz, Panchanan Maiti, Oien, Derek B., Tingyu Liu, Hayes, Jane, Liu, Tingyu, Gal Bitan, Moskovitz, Jackob, Maiti, Panchanan, Bitan, Gal, Derek B. Oien, Aida Attar, Lopes, Dahabada H. J.   +17 more
core   +1 more source

Methyl 4‐O‐Demethylbarbatate Destabilises HIF‐1α and Enhances Temozolomide Sensitivity in Glioma Cells

Cell Proliferation, EarlyView.
The lichen‐derived metabolite methyl 4‐O‐demethylbarbatate (Me‐4‐O‐DBA) suppresses glioma stemness, motility, and metabolic plasticity through inhibition of HIF‐1α signaling and synergistically enhances temozolomide activity, highlighting a potential strategy to target stemness‐driven therapeutic resistance in glioma.
Rui Zhou, Mücahit Varlı, Rundong Liu, Jieun Yu, Hyung‐Ho Ha, Jae‐Seoun Hur, Sang Kyum Kim, Hahyun Park, Hangun Kim   +8 more
wiley   +1 more source

The Neisseria gonorrhoeae Methionine Sulfoxide Reductase (MsrA/B) Is a Surface Exposed, Immunogenic, Vaccine Candidate [PDF]

, 2019
Control of the sexually transmitted infection gonorrhea is a major public health challenge, due to the recent emergence of multidrug resistant strains of Neisseria gonorrhoeae, and there is an urgent need for novel therapies or a vaccine to prevent ...
Kate L. Seib, Freda E.-C. Jen, Christopher J. Day, Evgeny A. Semchenko, Michael P. Jennings, Jen, Freda E-C, Jennings, Michael P, Semchenko, Evgeny A, Seib, Kate L, Day, Christopher J   +9 more
core   +1 more source

Energetic dysregulations in psychotic disorders: Targets for new therapeutics

The FEBS Journal, EarlyView.
The present review synthesizes literature documenting aberrant energy production and use, specifically related to mitochondrial and redox dysregulation, in psychotic disorders. Findings from different levels of investigation—genetic, cellular, and in vivo imaging—converge on aberrant energy metabolism as a hallmark of psychotic disorders.
Jacey Anderson, Kai‐Christian Sonntag, Thao Do Vy Le, Kaitlin Shannon, Chao Wang, Fei Du, Xi Chen, Donna McPhie, Dost Ongur, Bruce Cohen, Virginie‐Anne Chouinard   +10 more
wiley   +1 more source

Reduction of DABS-L-methionine-dl-sulfoxide by protein methionine sulfoxide reductase from polymorphonuclear leukocytes: stereospecificity towards the l-sulfoxide

, 1994
A new synthetic substrate for protein methionine sulfoxide reductase is proposed. We show that extracts from human polymorphonuclear leukocytes can reduce 4-dimethylaminoazobenzene-4'-sulfonyl-L-methionine-dl-sulfoxide [DABS-L-Met-dl-(O)] to the ...
BROVELLI, AUGUSTA, MINETTI, GIAMPAOLO, BALDUINI, CESARE   +2 more
core  

Methionine sulfoxide reductase regulates brain catechol-O-methyl transferase activity [PDF]

, 2014
This is the published version. Copyright 2014 Oxford University PressCatechol-O-methyl transferase (COMT) plays a key role in the degradation of brain dopamine (DA).
Moskovitz, Jackob, Cruz, Dianne A., Bortolato, Marco, Walss-Bass, Consuelo, Thompson, Peter M.   +4 more
core   +1 more source

Evolutionary Conserved and Divergent Responses to Copper Zinc Superoxide Dismutase Inhibition in Plants

Plant, Cell &Environment, EarlyView.
ABSTRACT After an initial evolution in a reducing environment, life got successively challenged by reactive oxygen species (ROS), especially during the great oxidation event (GOE) that followed the development of photosynthesis. Therefore, ROS are deeply intertwined into the physiological, morphological and transcriptional responses of most present‐day
Stephanie Frohn, Fabian B. Haas, Benjamin G. Chavez, Bernd H. Dreyer, Erik V. Reiss, Anne Ziplys, Heiko Weichert, Saskia Hiltemann, José M. Ugalde, Andreas J. Meyer, John C. D'Auria, Stefan A. Rensing, Jos H. M. Schippers   +12 more
wiley   +1 more source

Anaerobic respiration of host-derived methionine sulfoxide protects intracellular Salmonella from the phagocyte NADPH oxidase [PDF]

Intracellular Salmonella experiencing oxidative stress downregulates aerobic respiration. To maintain cellular energetics during periods of oxidative stress, intracellular Salmonella must utilize terminal electron acceptors of lower energetic value than ...
Kim, Ju-Sim, Kant, Sashi, Uppalapati, Siva, Orlicky, David J, Davenport, Bennett J, Margolis, Alyssa, Morrison, Thomas E, Vazquez-Torres, Andres, Jones-Carson, Jessica, McClelland, Michael, Matsuda, Jennifer, Liu, Lin   +11 more
core   +1 more source

Structure and electron-transfer pathway of the human methionine sulfoxide reductase MsrB3

, 2020
Introduction: The post-translational oxidation of methionine to methionine sulfoxide is a reversible process, enabling repair of oxidative damage to proteins and the use of sulfoxidation as a regulatory switch.
Resnick, Efrat, Gabizon, Ronen, Cao, Zhenbo, Javitt, Gabriel, Fass, Deborah, Bulleid, Neil   +5 more
core   +1 more source