Results 1 to 10 of about 151,393 (293)

Methotrexate Crystals on Electron Microscopy of Kidney Biopsy for Acute Kidney Injury [PDF]

Kidney Medicine
Acute kidney injury secondary to methotrexate therapy for hematologic malignancies is relatively uncommon. Methotrexate crystals in these cases are rarely seen on kidney biopsy, and in particular, their appearance in tissue prepared for transmission ...
Diana Fang, MD, Noah Poznanski, MD, Lois J. Arend, MD, PhD   +2 more
doaj   +2 more sources

Methotrexate-induced leukoencephalopathy presenting as acute-onset limb weakness in a child: a case report [PDF]

Journal of Medical Case Reports
Background Methotrexate is an essential medicine used to treat childhood malignancies including acute lymphoblastic leukemia. Neurotoxicity manifesting as leukoencephalopathy is an important adverse effect of methotrexate.
Hashan Pathiraja, Gayathri de Abrew, Linushika de Silva, Sanjaya Fernando, Shobhavi Randeny, Sachith Mettananda   +5 more
doaj   +2 more sources

Retrospective evaluation and prediction of clearance and toxicity of high dose methotrexate in childhood acute lymphoblastic leukemia patients

Brazilian Journal of Pharmaceutical Sciences, 2021
To find the predictors of High Dose Methotrexate toxicities in childhood Acute Lymphoblastic Leukemia Patients. This study included 198 Childhood Acute Lymphoblastic Leukemia patients (303 infusions) who were treated with High Dose Methotrexate ...
Yuxia Shan, Hui Gao, Zhong Li, Jinghua Li, Yang Liu, Lujuan Li, Qi Zhang   +6 more
doaj   +1 more source

Prevalence of methotrexate intolerance in juvenile idiopathic arthritis and possible risk factors: a tertiary center experience

The Journal of Pediatric Academy, 2022
Methotrexate that has a safe and inexpensive profile is a first choice of juvenile idiopathic arthritis treatment. Nevertheless, gastrointestinal symptoms are not serious but common side effects of methotrexate.
Zahide Ekici Tekin, Melike Mehveş Kaplan, Merve Cansu Polat, Elif Çelikel, Vildan Güngörer, Tuba Kurt, Nilüfer Tekgöz, Müge Sezer, Cüneyt Karagöl, Serkan Coşkun, Nimet Öner, Banu Çelikel Acae   +11 more
doaj   +1 more source

The effects of casticin and myricetin on liver damage induced by methotrexate in rats [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): In this study, we evaluated the therapeutic effects of casticin and myricetin on liver  damage induced by methotrexate in rats.Materials and Methods: Thirty-six male rats were used for the study and divided into 6 groups: control ...
Fazile Nur Eki̇nci̇-Akdemi̇r, Serkan Yıldırım, Fatih Mehmet Kandemir, İlhami Gülçi̇n, sefa Küçükler, Yavuz Selim Sağlam, Selvinaz Yakan   +6 more
doaj   +1 more source

Effect of methotrexate on neurobehavior and cholinesterase in chicks [PDF]

Iraqi Journal of Veterinary Sciences, 2023
This reading aimed to determine the therapeutic index of methotrexate (MTX) with a note on the consequence of methotrexate in chicks on neurobehavioral in addition to calculating the activity for cholinesterase in plasma and brain in chicks.
Maab A. Fadel, Khayrea A. Mustafa, Imad A. Thanoon   +2 more
doaj   +1 more source

A Rare Case of Methotrexate Induced Pancreatitis in Ectopic Pregnancy

The Ewha Medical Journal, 2023
Ectopic pregnancy (EP) refers to blastocyst implantation outside the uterine endometrium. EP is major cause of maternal morbidity and mortality. Treatment options include surgery, medical therapy with methotrexate,
Jiwon Choi, Mina Kang, Young Min Hur, Young Ju Kim, Sunwha Park   +4 more
doaj   +1 more source

Harmine Has Nephroprotective Effect Against Methotrexate-Induced Injury in Mice via Inhibition of Oxidative Stress [PDF]

Research Journal of Pharmacognosy, 2021
Background and objectives: Despite clinical use, the efficacy of methotrexate is often limited by some adverse effects, mainly nephrotoxicity. The most common mechanism of methotrexate-induced kidney damages is oxidative stress.
Cyrus Jalili, Sara Darakhshan, Nasim Akhshi, Amir Abdolmaleki, Abdolnasir Abdi, Ali Ghanbari*   +5 more
doaj   +1 more source

Polyglutamation of methotrexate. Is methotrexate a prodrug? [PDF]

Journal of Clinical Investigation, 1985
La polyglutamation est assuree par la folyl polyglutamyl synthetase.
J Baram, Shoichi Koizumi, Bruce A. Chabner, Gregory A. Curt, Jacques Jolivet, N J Clendeninn, Carmen J. Allegra, James C. Drake   +7 more
openaire   +3 more sources

Sustained Remission and Outcomes with Abatacept plus Methotrexate Following Stepwise Dose De-escalation in Patients with Early Rheumatoid Arthritis

Rheumatology and Therapy, 2023
Introduction One target of rheumatoid arthritis (RA) treatment is to achieve early sustained remission; over the long term, patients in sustained remission have less structural joint damage and physical disability.
Paul Emery, Yoshiya Tanaka, Vivian P. Bykerk, Thomas W. J. Huizinga, Gustavo Citera, Clifton O. Bingham, Subhashis Banerjee, Benjamin P. Soule, Marleen Nys, Sean E. Connolly, Karissa L. Lozenski, Joe Zhuo, Robert Wong, Kuan-Hsiang Gary Huang, Roy Fleischmann   +14 more
doaj   +1 more source