Results 1 to 10 of about 351,839 (294)
TURKDERM, 2022 Methotrexate is a drug used in the treatment of psoriasis and psoriatic arthritis. It shows its effect by binding to dihydrofolate reductase, reducing purine synthesis and cell proliferation. When used as a monotherapy, methotrexate shows its effect late and achieves a 50-75% recovery in skin lesions.
野崎 芳胤 +2 more
openaire +4 more sources
The effects of casticin and myricetin on liver damage induced by methotrexate in rats [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): In this study, we evaluated the therapeutic effects of casticin and myricetin on liver damage induced by methotrexate in rats.Materials and Methods: Thirty-six male rats were used for the study and divided into 6 groups: control ...
Fazile Nur Eki̇nci̇-Akdemi̇r +6 more
doaj +2 more sources
Brazilian Journal of Pharmaceutical Sciences, 2021 To find the predictors of High Dose Methotrexate toxicities in childhood Acute Lymphoblastic Leukemia Patients. This study included 198 Childhood Acute Lymphoblastic Leukemia patients (303 infusions) who were treated with High Dose Methotrexate ...
Yuxia Shan +6 more
doaj +1 more source
Effect of methotrexate on neurobehavior and cholinesterase in chicks [PDF]
Iraqi Journal of Veterinary Sciences, 2023 This reading aimed to determine the therapeutic index of methotrexate (MTX) with a note on the consequence of methotrexate in chicks on neurobehavioral in addition to calculating the activity for cholinesterase in plasma and brain in chicks.
Maab A. Fadel +2 more
doaj +1 more source
Annals of the Rheumatic Diseases, 2021 Objective To investigate the humoral and cellular immune response to messenger RNA (mRNA) COVID-19 vaccines in patients with immune-mediated inflammatory diseases (IMIDs) on immunomodulatory treatment.
R. Haberman +25 more
semanticscholar +1 more source
The Journal of Pediatric Academy, 2022 Methotrexate that has a safe and inexpensive profile is a first choice of juvenile idiopathic arthritis treatment. Nevertheless, gastrointestinal symptoms are not serious but common side effects of methotrexate.
Zahide Ekici Tekin +11 more
doaj +1 more source
A Rare Case of Methotrexate Induced Pancreatitis in Ectopic Pregnancy
The Ewha Medical Journal, 2023 Ectopic pregnancy (EP) refers to blastocyst implantation outside the uterine endometrium. EP is major cause of maternal morbidity and mortality. Treatment options include surgery, medical therapy with methotrexate,
Jiwon Choi +4 more
doaj +1 more source
Harmine Has Nephroprotective Effect Against Methotrexate-Induced Injury in Mice via Inhibition of Oxidative Stress [PDF]
Research Journal of Pharmacognosy, 2021 Background and objectives: Despite clinical use, the efficacy of methotrexate is often limited by some adverse effects, mainly nephrotoxicity. The most common mechanism of methotrexate-induced kidney damages is oxidative stress.
Cyrus Jalili +5 more
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Polyglutamation of methotrexate. Is methotrexate a prodrug? [PDF]
Journal of Clinical Investigation, 1985 La polyglutamation est assuree par la folyl polyglutamyl synthetase.
J Baram +7 more
openaire +3 more sources
Rheumatology and Therapy, 2023 Introduction One target of rheumatoid arthritis (RA) treatment is to achieve early sustained remission; over the long term, patients in sustained remission have less structural joint damage and physical disability.
Paul Emery +14 more
doaj +1 more source