Results 1 to 10 of about 271,187 (352)
Factors related to dosing frequency and route of administration in methotrexate intolerance among patients with rheumatoid arthritis: a cross-sectional study. [PDF]
Ther Adv Drug SafBackground: Methotrexate is central to the management of rheumatoid arthritis (RA). However, its use is often limited by methotrexate intolerance. Objectives: This study aims to explore the association between alternative methotrexate dosing methods and ...
Almalag HM +9 more
europepmc +2 more sources
Brazilian Journal of Pharmaceutical Sciences, 2021 To find the predictors of High Dose Methotrexate toxicities in childhood Acute Lymphoblastic Leukemia Patients. This study included 198 Childhood Acute Lymphoblastic Leukemia patients (303 infusions) who were treated with High Dose Methotrexate ...
Yuxia Shan +6 more
doaj +1 more source
The Journal of Pediatric Academy, 2022 Methotrexate that has a safe and inexpensive profile is a first choice of juvenile idiopathic arthritis treatment. Nevertheless, gastrointestinal symptoms are not serious but common side effects of methotrexate.
Zahide Ekici Tekin +11 more
doaj +1 more source
The effects of casticin and myricetin on liver damage induced by methotrexate in rats [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): In this study, we evaluated the therapeutic effects of casticin and myricetin on liver damage induced by methotrexate in rats.Materials and Methods: Thirty-six male rats were used for the study and divided into 6 groups: control ...
Fazile Nur Eki̇nci̇-Akdemi̇r +6 more
doaj +1 more source
Harmine Has Nephroprotective Effect Against Methotrexate-Induced Injury in Mice via Inhibition of Oxidative Stress [PDF]
Research Journal of Pharmacognosy, 2021 Background and objectives: Despite clinical use, the efficacy of methotrexate is often limited by some adverse effects, mainly nephrotoxicity. The most common mechanism of methotrexate-induced kidney damages is oxidative stress.
Cyrus Jalili +5 more
doaj +1 more source
A Rare Case of Methotrexate Induced Pancreatitis in Ectopic Pregnancy
The Ewha Medical Journal, 2023 Ectopic pregnancy (EP) refers to blastocyst implantation outside the uterine endometrium. EP is major cause of maternal morbidity and mortality. Treatment options include surgery, medical therapy with methotrexate,
Jiwon Choi +4 more
doaj +1 more source
Effect of methotrexate on neurobehavior and cholinesterase in chicks [PDF]
Iraqi Journal of Veterinary Sciences, 2023 This reading aimed to determine the therapeutic index of methotrexate (MTX) with a note on the consequence of methotrexate in chicks on neurobehavioral in addition to calculating the activity for cholinesterase in plasma and brain in chicks.
Maab A. Fadel +2 more
doaj +1 more source
Polyglutamation of methotrexate. Is methotrexate a prodrug? [PDF]
Journal of Clinical Investigation, 1985 La polyglutamation est assuree par la folyl polyglutamyl synthetase.
J Baram +7 more
openaire +3 more sources
Methotrexate in the urine [PDF]
Kidney International, 2011 A 62-year-old man with a recent diagnosis of primary central nervous system lymphoma developed acute kidney injury (AKI) after administration of high-dose methotrexate. AKI developed within 48 h of therapy despite prior infusion of intravenous bicarbonate solution. Serum methotrexate level was 2.61 μmol/l at 24 h and 0.25 μmol/l 72 h after methotrexate
Michael W. Ross, Sandeep K. Mallipattu
openaire +3 more sources
Methotrexate and Pralatrexate [PDF]
Dermatologic Clinics, 2015 This article reviews methotrexate and the more potent, related compound, pralatrexate, for the treatment of cutaneous T-cell lymphomas, including mycosis fungoides, Sézary syndrome, and CD30+ lymphoproliferative disorders. Although these folate antagonists are traditionally viewed as antiproliferative cell cycle inhibitors, it is recognized that they ...
Jianqiang Wu, Gary S. Wood
openaire +2 more sources