Results 11 to 20 of about 369,868 (397)

Histidine catabolism is a major determinant of methotrexate sensitivity

Nature, 2018
The chemotherapeutic drug methotrexate inhibits the enzyme dihydrofolate reductase1, which generates tetrahydrofolate, an essential cofactor in nucleotide synthesis2. Depletion of tetrahydrofolate causes cell death by suppressing DNA and RNA production3.
Naama Kanarek, Heather R Keys, Caroline A Lewis   +2 more
exaly   +2 more sources

The effects of casticin and myricetin on liver damage induced by methotrexate in rats [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): In this study, we evaluated the therapeutic effects of casticin and myricetin on liver  damage induced by methotrexate in rats.Materials and Methods: Thirty-six male rats were used for the study and divided into 6 groups: control ...
Fazile Nur Eki̇nci̇-Akdemi̇r, Serkan Yıldırım, Fatih Mehmet Kandemir, İlhami Gülçi̇n, sefa Küçükler, Yavuz Selim Sağlam, Selvinaz Yakan   +6 more
doaj   +2 more sources

Methotrexate-induced acute neurotoxicity in patients with osteosarcoma: a case report [PDF]

Journal of Medical Case Reports
Background Methotrexate is commonly used to treat osteosarcoma and acute lymphoblastic leukemia. Methotrexate can rarely cause neurotoxicity with a wide range of presentations including seizure, hemiparesis, dysarthria, dysphagia, and more.
Olivia L. Makos, Nicole A. Shonka, Kealy M. Marth, Shawna L. Stricker, Mark Keiper, Makayla E. Schissel   +5 more
doaj   +2 more sources

Comparing the effectiveness and drug persistence of methotrexate, cyclosporine, and acitretin for psoriasis [PDF]

International Journal of Women's Dermatology
Background:. Conventional systemic agents remain the cornerstone treatment for psoriasis because of their availability and cost-effectiveness. However, few studies have compared the effectiveness and drug persistence of these agents in Asian populations.
Chayada Chaiyabutr, MD, Teerapat Paringkarn, MD, Narumol Silpa-archa, MD, Chanisada Wongpraprarut, MD, Leena Chularojanamontri, MD   +4 more
doaj   +2 more sources

A Comparison of Etanercept and Methotrexate in Patients with Early Rheumatoid Arthritis [PDF]

New England Journal of Medicine, 2000
Joan M. Bathon, Richard W. Martin, Roy Fleischmann, John Tesser, Michael Schiff, Edward Keystone, Mark C. Genovese, Mary Chester Wasko, Larry W. Moreland, Arthur L. Weaver, Joseph A. Markenson, Barbara Finck   +11 more
openalex   +2 more sources

Retrospective evaluation and prediction of clearance and toxicity of high dose methotrexate in childhood acute lymphoblastic leukemia patients

Brazilian Journal of Pharmaceutical Sciences, 2021
To find the predictors of High Dose Methotrexate toxicities in childhood Acute Lymphoblastic Leukemia Patients. This study included 198 Childhood Acute Lymphoblastic Leukemia patients (303 infusions) who were treated with High Dose Methotrexate ...
Yuxia Shan, Hui Gao, Zhong Li, Jinghua Li, Yang Liu, Lujuan Li, Qi Zhang   +6 more
doaj   +1 more source

Methotrexate hampers immunogenicity to BNT162b2 mRNA COVID-19 vaccine in immune-mediated inflammatory disease

Annals of the Rheumatic Diseases, 2021
Objective To investigate the humoral and cellular immune response to messenger RNA (mRNA) COVID-19 vaccines in patients with immune-mediated inflammatory diseases (IMIDs) on immunomodulatory treatment.
R. Haberman, R. Herati, D. Simon, M. Samanovic, R. Blank, M. Tuen, Sergei B Koralov, R. Atreya, K. Tascilar, J. Allen, R. Castillo, A. Cornelius, P. Rackoff, G. Solomon, S. Adhikari, N. Azar, P. Rosenthal, P. Izmirly, J. Samuels, B. Golden, S. Reddy, M. Neurath, S. Abramson, G. Schett, M. Mulligan, J. Scher   +25 more
semanticscholar   +1 more source

Overview of Methotrexate Toxicity: A Comprehensive Literature Review

Cureus, 2022
Methotrexate (MTX) is significantly more effective than and has a considerable advantage over placebo in patients with severe and persistent rheumatoid arthritis (RA). The drug is used to treat a variety of malignant disorders (leukemia and cancer of the
Khalid M Hamed, I. Dighriri, Abdulrahman F Baomar, B. T. Alharthy, Foza E Alenazi, Gadheer H Alali, R. H. Alenazy, Nidaa Alhumaidi, Dania H Alhulayfi, Yasmen B Alotaibi, Sarah S Alhumaidan, Z. Alhaddad, Adhwa'a A Humadi, Shahad A. Alzahrani, Rahaf H Alobaid   +14 more
semanticscholar   +1 more source

Prevalence of methotrexate intolerance in juvenile idiopathic arthritis and possible risk factors: a tertiary center experience

The Journal of Pediatric Academy, 2022
Methotrexate that has a safe and inexpensive profile is a first choice of juvenile idiopathic arthritis treatment. Nevertheless, gastrointestinal symptoms are not serious but common side effects of methotrexate.
Zahide Ekici Tekin, Melike Mehveş Kaplan, Merve Cansu Polat, Elif Çelikel, Vildan Güngörer, Tuba Kurt, Nilüfer Tekgöz, Müge Sezer, Cüneyt Karagöl, Serkan Coşkun, Nimet Öner, Banu Çelikel Acae   +11 more
doaj   +1 more source

Effect of methotrexate on neurobehavior and cholinesterase in chicks [PDF]

Iraqi Journal of Veterinary Sciences, 2023
This reading aimed to determine the therapeutic index of methotrexate (MTX) with a note on the consequence of methotrexate in chicks on neurobehavioral in addition to calculating the activity for cholinesterase in plasma and brain in chicks.
Maab A. Fadel, Khayrea A. Mustafa, Imad A. Thanoon   +2 more
doaj   +1 more source