Results 11 to 20 of about 154,899 (297)
Polyglutamation of methotrexate. Is methotrexate a prodrug? [PDF]
Journal of Clinical Investigation, 1985 La polyglutamation est assuree par la folyl polyglutamyl synthetase.
J Baram +7 more
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Methotrexate in the urine [PDF]
Kidney International, 2011 A 62-year-old man with a recent diagnosis of primary central nervous system lymphoma developed acute kidney injury (AKI) after administration of high-dose methotrexate. AKI developed within 48 h of therapy despite prior infusion of intravenous bicarbonate solution. Serum methotrexate level was 2.61 μmol/l at 24 h and 0.25 μmol/l 72 h after methotrexate
Michael W. Ross, Sandeep K. Mallipattu
openaire +3 more sources
American Journal of Hematology, Volume 98, Issue 1, Page 159-165, January 2023., 2023 Donor stem cell product undergoes CD34 stem cell selection. CD34 positive stem cells are used for transplantation. Pathogen‐ and leukemia‐specific T‐cells are manufactured from CD34 negative fraction and infused prophylactically 21 days after transplant.
David J. Gottlieb +12 more
wiley +1 more source
Methotrexate and Pralatrexate [PDF]
Dermatologic Clinics, 2015 This article reviews methotrexate and the more potent, related compound, pralatrexate, for the treatment of cutaneous T-cell lymphomas, including mycosis fungoides, Sézary syndrome, and CD30+ lymphoproliferative disorders. Although these folate antagonists are traditionally viewed as antiproliferative cell cycle inhibitors, it is recognized that they ...
Jianqiang Wu, Gary S. Wood
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Journal of Ophthalmic and Vision Research, 2021 Intravitreal methotrexate (MTX) has been proven to be an effective treatment for various intraocular diseases. In this article, a comprehensive review was performed on intravitreal applications of methotrexate. Different aspects of the administration of intravitreal MTX for various clinical conditions such as intraocular tumors, proliferative ...
Fatemeh Abdi +2 more
openaire +4 more sources
Cutaneous T‐cell lymphomas: 2023 update on diagnosis, risk‐stratification, and management
American Journal of Hematology, Volume 98, Issue 1, Page 193-209, January 2023., 2023 Abstract Disease Overview Cutaneous T‐cell lymphomas are a heterogenous group of T‐cell neoplasms involving the skin, the majority of which may be classified as Mycosis Fungoides (MF) or Sézary Syndrome (SS). Diagnosis The diagnosis of MF or SS requires the integration of clinical and histopathologic data.
Alexandra C. Hristov +2 more
wiley +1 more source
TURKDERM, 2022 Methotrexate is a drug used in the treatment of psoriasis and psoriatic arthritis. It shows its effect by binding to dihydrofolate reductase, reducing purine synthesis and cell proliferation. When used as a monotherapy, methotrexate shows its effect late and achieves a 50-75% recovery in skin lesions.
openaire +3 more sources
Arthritis &Rheumatology, EarlyView., 2023 Objective A simple, scalable tool that identifies psoriasis patients at high risk for developing psoriatic arthritis (PsA) could improve early diagnosis. We aimed to develop a risk prediction model for the development of PsA and to assess its performance among patients with psoriasis.
Lihi Eder +8 more
wiley +1 more source
The pharmacogenetics of methotrexate [PDF]
Rheumatology, 2007 Methotrexate (MTX) is a cornerstone of therapy for rheumatoid arthritis. However, it is not universally effective and up to one-third of patients fail to respond to treatment, either because of inefficacy or adverse events, although at present it is not possible to predict therapy response accurately.
Samantha L. Hider +2 more
openaire +2 more sources
Medical system error causing methotrexate poisoning and delay in diagnosis: report of two cases
Journal of Emergency Practice and Trauma, 2021 Objective: We are going to alert the emergency physicians to be aware of drugs side effects. Some drugs like methotrexate are not routine drugs, and the symptoms may be miss diagnosed if not completely notified.
Hamidreza Reihani
doaj +1 more source