Results 11 to 20 of about 163,856 (309)
Polyglutamation of methotrexate. Is methotrexate a prodrug? [PDF]
Journal of Clinical Investigation, 1985 La polyglutamation est assuree par la folyl polyglutamyl synthetase.
J Baram +7 more
openaire +3 more sources
Methotrexate in the urine [PDF]
Kidney International, 2011 A 62-year-old man with a recent diagnosis of primary central nervous system lymphoma developed acute kidney injury (AKI) after administration of high-dose methotrexate. AKI developed within 48 h of therapy despite prior infusion of intravenous bicarbonate solution. Serum methotrexate level was 2.61 μmol/l at 24 h and 0.25 μmol/l 72 h after methotrexate
Michael W. Ross, Sandeep K. Mallipattu
openaire +3 more sources
Methotrexate and Pralatrexate [PDF]
Dermatologic Clinics, 2015 This article reviews methotrexate and the more potent, related compound, pralatrexate, for the treatment of cutaneous T-cell lymphomas, including mycosis fungoides, Sézary syndrome, and CD30+ lymphoproliferative disorders. Although these folate antagonists are traditionally viewed as antiproliferative cell cycle inhibitors, it is recognized that they ...
Jianqiang Wu, Gary S. Wood
openaire +2 more sources
Journal of Ophthalmic and Vision Research, 2021 Intravitreal methotrexate (MTX) has been proven to be an effective treatment for various intraocular diseases. In this article, a comprehensive review was performed on intravitreal applications of methotrexate. Different aspects of the administration of intravitreal MTX for various clinical conditions such as intraocular tumors, proliferative ...
Fatemeh Abdi +2 more
openaire +4 more sources
TURKDERM, 2022 Methotrexate is a drug used in the treatment of psoriasis and psoriatic arthritis. It shows its effect by binding to dihydrofolate reductase, reducing purine synthesis and cell proliferation. When used as a monotherapy, methotrexate shows its effect late and achieves a 50-75% recovery in skin lesions.
openaire +3 more sources
Journal of Medical Case Reports, 2019 Background Methotrexate, an immunosuppressant, is widely used as the standard therapeutic drug for rheumatoid arthritis. With the increasing frequency of use of methotrexate, adverse effects of methotrexate have been reported, one of which is known as ...
Ryohei Ono +6 more
doaj +1 more source
Medical system error causing methotrexate poisoning and delay in diagnosis: report of two cases
Journal of Emergency Practice and Trauma, 2021 Objective: We are going to alert the emergency physicians to be aware of drugs side effects. Some drugs like methotrexate are not routine drugs, and the symptoms may be miss diagnosed if not completely notified.
Hamidreza Reihani
doaj +1 more source
Clinics, 2008 INTRODUCTION: Methotrexate, a folate antagonist, is a mainstay treatment for childhood acute lymphoblastic leukemia. It is also widely used in a low dose formulation to treat patients with rheumatoid arthritis.
Sampath Madhyastha +3 more
doaj +1 more source
RMD Open, 2023 Introduction We aimed to compare the proportions of patients with newly diagnosed psoriatic arthritis (PsA) and rheumatoid arthritis (RA) remaining on methotrexate (regardless of other disease-modifying antirheumatic drug (DMARD)-changes), and ...
Ulf Lindström +7 more
doaj +1 more source
The pharmacogenetics of methotrexate [PDF]
Rheumatology, 2007 Methotrexate (MTX) is a cornerstone of therapy for rheumatoid arthritis. However, it is not universally effective and up to one-third of patients fail to respond to treatment, either because of inefficacy or adverse events, although at present it is not possible to predict therapy response accurately.
Samantha L. Hider +2 more
openaire +2 more sources