Results 41 to 50 of about 351,938 (393)

SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia

Leukemia, 2020
Folate metabolism enables cell growth by providing one-carbon (1C) units for nucleotide biosynthesis. The 1C units are carried by tetrahydrofolate, whose production by the enzyme dihydrofolate reductase is targeted by the important anticancer drug ...
J. García-Cañaveras, Olga Lancho, Gregory S. Ducker, J. Ghergurovich, Xincheng Xu, Victoria da Silva-Diz, S. Minuzzo, S. Indraccolo, Hahn Kim, D. Herranz, J. Rabinowitz   +10 more
semanticscholar   +1 more source

Influence of pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury model rats by HPLC-MS

Asian Journal of Pharmaceutical Sciences, 2017
The present study was designed to investigate the influence of the pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury rats.
Huiyan Shi, Chenzhi Hou, Liqiang Gu, Zhe Wei, Hang Xing, Meiyu Zhang, Shixiao Wang, Longshan Zhao, Kaishun Bi, Xiaohui Chen   +9 more
doaj   +1 more source

Induction of Erythrocyte Membrane Blebbing by Methotrexate-Induced Oxidative Stress

Dose-Response, 2022
Methotrexate (MTX) is a common chemotherapeutical agent and folate antagonist with reported apoptotic activity in nucleated cells. The presented research work was planned to investigate the eryptotic effects of methotrexate after the exposure of ...
Tayyba Sattar, Kashif Jilani, Khalida Parveen, Zahid Mushtaq, Haq Nawaz, Maham Abdul Bari Khan   +5 more
doaj   +1 more source

Etanercept and Methotrexate as Monotherapy or in Combination for Psoriatic Arthritis: Primary Results From a Randomized, Controlled Phase III Trial

Arthritis & Rheumatology, 2019
To examine the efficacy of methotrexate monotherapy relative to etanercept monotherapy and the value of combining methotrexate and etanercept for the treatment of patients with psoriatic arthritis (PsA).
P. Mease, D. Gladman, D. Collier, C. Ritchlin, P. Helliwell, L. Liu, G. Kricorian, J. Chung   +7 more
semanticscholar   +1 more source

Effects of intraventricular methotrexate administration on Cuprizone-induced demyelination in mice

Frontiers in Molecular Neuroscience, 2013
We previously showed that intrathecal administration of methotrexate slowed disability progression in multiple sclerosis patients with progressive disease. In general MS patients with progressive disease respond poorly to anti-inflammatory therapies.
Andre Michael Mueller, Adam eNassery, Hana eConlon, Xinhe eLiu, Massimiliano eCristofanilli, Esther eJun, Bo Hyung eYoon, Saud Ahmed Sadiq   +7 more
doaj   +1 more source

The effects of tumour necrosis factor inhibitors, methotrexate, non-steroidal anti-inflammatory drugs and corticosteroids on cardiovascular events in rheumatoid arthritis, psoriasis and psoriatic arthritis: a systematic review and meta-analysis

Annals of the Rheumatic Diseases, 2015
The objective of this systematic literature review was to determine the association between cardiovascular events (CVEs) and antirheumatic drugs in rheumatoid arthritis (RA) and psoriatic arthritis (PsA)/psoriasis (Pso).
C. Roubille, V. Richer, T. Starnino, C. McCourt, Alexandra Mcfarlane, P. Fleming, S. Siu, J. Kraft, C. Lynde, J. Pope, W. Gulliver, S. Keeling, J. Dutz, L. Bessette, R. Bissonnette, B. Haraoui   +15 more
semanticscholar   +1 more source

Long-term study of the impact of methotrexate on serum cytokines and lymphocyte subsets in patients with active rheumatoid arthritis: correlation with pharmacokinetic measures [PDF]

, 2016
Objective To describe changes in immune parameters observed during long-term methotrexate (MTX) therapy in patients with active rheumatoid arthritis (RA) and explore correlations with simultaneously measured MTX pharmacokinetic (PKC) parameters ...
Hamilton, Robert, Kremer, Joel M., Lawrence, David A., McInnes, Iain B.   +3 more
core   +1 more source

Histidine catabolism is a major determinant of methotrexate sensitivity

Nature, 2018
The chemotherapeutic drug methotrexate inhibits the enzyme dihydrofolate reductase1, which generates tetrahydrofolate, an essential cofactor in nucleotide synthesis2. Depletion of tetrahydrofolate causes cell death by suppressing DNA and RNA production3.
Naama Kanarek, Heather R. Keys, J. Cantor, C. Lewis, Sze Ham Chan, Tenzin Kunchok, Monther Abu-Remaileh, Elizaveta Freinkman, Lawrence D. Schweitzer, D. Sabatini   +9 more
semanticscholar   +1 more source

A Comparison of Psoriasis Severity in Pediatric Patients Treated With Methotrexate vs Biologic Agents.

JAMA dermatology, 2020
Importance Few studies have compared the use of methotrexate and biologics, the most commonly used systemic medications for treatment of moderate to severe psoriasis in children.
I. M. Bronckers, A. Paller, D. West, I. Lara‐Corrales, M. Tollefson, W. Tom, M. Hogeling, Leah T. Belazarian, C. Zachariae, E. Mahé, E. Siegfried, U. Blume-Peytavi, Z. Szalai, R. Vleugels, K. Holland, R. Murphy, L. Puig, K. Cordoro, J. Lambert, A. Alexopoulos, U. Mrowietz, W. Kievit, M. Seyger   +22 more
semanticscholar   +1 more source

Guidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis : Fundamentals Of Care for UveitiS (FOCUS) Initiative [PDF]

, 2018
Supplemental material available at www.aaojournal.org. Supported by AbbVie, Inc., and the Fundamentals of Care for Uveitis Initiative National Faculty.
Accorinti, Massimo, Acharya, Nisha, Adan, Alfredo, Agrawal, Rupesh, Akkoc, Nurullah, Al Ghamdi, Saed, Al Ghamdi, Turki, Al Saati, Anood, Al-Dhibi, Hassan A., Al-Shamarani, Mohamed, Alsabaani, Nasser, Bachta, Artur, Barisani-Asenbauer, Talin, Beare, Nicholas, Belfort, Rubens, Blanco, Ricardo, Brézin, Antoine P., Carreño, Ester, Chandran, Vinod, Chee, Soon Phaik, Chiquet, Christophe, Chng, Hiok Hee, Cimbalas, Andrius, Cimino, Luca, Cordero-Coma, Miguel, Cristobal, Couto, Cuevas, Miguel, Davis, Janet L., de Boer, Joke, de la Torre, Alejandra, De Schryver, Ilse, Derzko-Dzulynsky, Larissa, Diaz-Valle, David, Dick, Andrew D., Eurico da Fonseca, João, Facsko, Andrea, Figueira, Luis, Fundamentals of Care for Uveitis International Consensus Group, Kuffova, Lucia, Merino, Claudia Eugenia Duran, Murphy, Conor, Nascimento, Heloisa, Porto, Fernanda Belga Ottoni, Ramanan, Athimalaipet V., Rosenbaum, James T., Salah, Sawsen, Salek, Sherveen, Siak, Jay, Sonoda, Koh Hei, Steeples, Laura, Yee, Anita Chan Sook   +50 more
core   +4 more sources