Results 1 to 10 of about 1,069,555 (390)

Comparison between D-loop methylation and mtDNA copy number in patients with Aicardi-Goutières Syndrome

Frontiers in Endocrinology, 2023
IntroductionAicardi-Goutières Syndrome (AGS) is a rare encephalopathy with early onset that can be transmitted in both dominant and recessive forms. Its phenotypic covers a wide range of neurological and extraneurological symptoms.
Francesca Dragoni, Francesca Dragoni, Jessica Garau, Simona Orcesi, Simona Orcesi, Costanza Varesio, Costanza Varesio, Matteo Bordoni, Eveljn Scarian, Eveljn Scarian, Rosalinda Di Gerlando, Rosalinda Di Gerlando, Elisa Fazzi, Elisa Fazzi, Roberta Battini, Roberta Battini, Altea Gjurgjaj, Bartolo Rizzo, Orietta Pansarasa, Stella Gagliardi   +19 more
doaj   +1 more source

Methyl 2-methyl-3,5-dinitrobenzoate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
In the title compound, C(9)H(8)N(2)O(6), the methyl ester group is almost planar (r.m.s. deviation = 0.002 Å) and is oriented at a dihedral angle of 24.27 (16) ° with respect to the benzene ring. The nitro groups make dihedral angles of 4.2 (5) ° and 60.21 (11) ° with the benzene ring.
Rizwan Raza, Aisha Saddiqa, Muhammad Nawaz Tahir, Muhammad Danish, Mohammad S. Iqbal   +4 more
openaire   +3 more sources

Identification of novel immune-related molecular subtypes and a prognosis model to predict thyroid cancer prognosis and drug resistance

Frontiers in Pharmacology, 2023
Background: Thyroid cancer is a common malignant tumor of the endocrine system that has shown increased incidence in recent decades. We explored the relationship between tumor-infiltrating immune cell classification and the prognosis of thyroid carcinoma.
Wei Zhang, Ting Liu, Xinyi Li, Tianshu Li, Xiangchi Ma, Dongxu Zhao, Yueyang Liu, Xueke Zheng, Xudong Zhao   +8 more
doaj   +1 more source

Protein post-translational modification in SARS-CoV-2 and host interaction

Frontiers in Immunology, 2023
SARS-CoV-2 can cause lung diseases, such as pneumonia and acute respiratory distress syndrome, and multi-system dysfunction. Post-translational modifications (PTMs) related to SARS-CoV-2 are conservative and pathogenic, and the common PTMs are ...
Nana Cheng, Nana Cheng, Mingzhu Liu, Wanting Li, BingYue Sun, Dandan Liu, Guoqing Wang, Jingwei Shi, Lisha Li   +8 more
doaj   +1 more source

Synthesis of (.+-.)-methyl epijasmonate and (.+-.)-methyl cucurbate. [PDF]

Agricultural and Biological Chemistry, 1987
A novel synthesis of ( ± )-methyl epijasomonate (2) and the first synthesis of ( ± )-methyl cucurbate (4) were achieved starting from 2-allylcyclohexane-1,3-dione (8). The synthetic epimer 2 had a stronger jasmin flavor than the trans-isomer 1 with 95% purity.
Takeshi Kitahara, Katsutoshi Miura, Yasuhiro Warita, Yoshikazu Takagi, Kenji Mori   +4 more
openaire   +1 more source

Pharmacokinetic study of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement product

BMC Pharmacology and Toxicology, 2020
Background A novel, high bioavailability oral, enteric coated tablet formulation of S-adenosylmethionine (MSI-195) has been developed for life science application.
Beth R. Cameron, Ludvina Ferreira, I. David MacDonald   +2 more
doaj   +1 more source

Omics-informed CNV calls reduce false-positive rates and improve power for CNV-trait associations

HGG Advances, 2022
Summary: Copy-number variations (CNV) are believed to play an important role in a wide range of complex traits, but discovering such associations remains challenging.
Maarja Lepamets, Chiara Auwerx, Margit Nõukas, Annique Claringbould, Eleonora Porcu, Mart Kals, Tuuli Jürgenson, Andrew Paul Morris, Urmo Võsa, Murielle Bochud, Silvia Stringhini, Cisca Wijmenga, Lude Franke, Hedi Peterson, Jaak Vilo, Kaido Lepik, Reedik Mägi, Zoltán Kutalik   +17 more
doaj   +1 more source

Methyl 4-methylbenzoate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2008
The structure of the title compound, C(9)H(10)O(2), is related to that of 4-methyl-phenyl 4-methyl-benzoate and ethyl-ene di-4-methyl-benzoate showing similar bond parameters. The mol-ecule is planar, the dihedral angle between the aromatic ring and the -COOMe group being 0.95 (6)°. The cystal structure exhibits inter-molecular C-H⋯O contacts that link
Ulrich Flörke, Hummera Rafique, Aamer Saeed   +2 more
openaire   +3 more sources

Changes in Higher-Order Chromosomal Structure of Klebsiella pneumoniae Under Simulated Microgravity

Frontiers in Microbiology, 2022
Our previous work have shown that certain subpopulations of Klebsiella pneumoniae exhibit significant phenotypic changes under simulated microgravity (SMG), including enhanced biofilm formation and cellulose synthesis, which may be evoked by changes in ...
Yahao Wang, Wenlong Shen, Man Yin, Wenhua Huang, Bingyu Ye, Ping Li, Shu Shi, Ge Bai, Xinjie Guo, Yifei Jin, Kailin Lin, Yan Zhang, Yongqiang Jiang, Junfeng Wang, Yanping Han, Zhihu Zhao   +15 more
doaj   +1 more source

Methylation of demethylavermectins [PDF]

Antimicrobial Agents and Chemotherapy, 1987
Demethylavermectins, which lack methyl groups on the oleandrose moiety, were fed to wild-type "Streptomyces avermitilis," which produces the normal avermectin components, and the bioconversion products were identified. The oleandrose units of the demethylavermectins were not methylated by the wild-type strain, but the C-5 of the macrolide ring was ...
M D, Schulman, C, Ruby
openaire   +2 more sources