Results 1 to 10 of about 1,073,449 (389)

Protein post-translational modification in SARS-CoV-2 and host interaction

Frontiers in Immunology, 2023
SARS-CoV-2 can cause lung diseases, such as pneumonia and acute respiratory distress syndrome, and multi-system dysfunction. Post-translational modifications (PTMs) related to SARS-CoV-2 are conservative and pathogenic, and the common PTMs are ...
Nana Cheng, Nana Cheng, Mingzhu Liu, Wanting Li, BingYue Sun, Dandan Liu, Guoqing Wang, Jingwei Shi, Lisha Li   +8 more
doaj   +1 more source

Genetic plasma biomarkers associated with ischemic stroke

Exploration of Neuroscience, 2023
Aim: Stroke is one of the leading causes of death and disability worldwide. Plasma biomarkers have long been used to evaluate physiological or pathological processes and to make predictions about the outcome of stroke patients.
Mihai Andrei Ruscu, Daiana Burdusel, Andreea-Mihaela Cercel, Madalina Aldea, Dirk M. Hermann, Israel Fernandez Cadenas, Thorsten R. Doeppner, Roxana Surugiu, Aurel Popa-Wagner   +8 more
doaj   +1 more source

Epigenetic associations with adolescent grey matter maturation and cognitive development

Frontiers in Genetics, 2023
Introduction: Adolescence, a critical phase of human neurodevelopment, is marked by a tremendous reorganization of the brain and accompanied by improved cognitive performance. This development is driven in part by gene expression, which in turn is partly
Dawn Jensen, Dawn Jensen, Jiayu Chen, Jiayu Chen, Jessica A. Turner, Jessica A. Turner, Julia M. Stephen, Yu-Ping Wang, Tony W. Wilson, Vince D. Calhoun, Vince D. Calhoun, Vince D. Calhoun, Vince D. Calhoun, Vince D. Calhoun, Jingyu Liu, Jingyu Liu   +15 more
doaj   +1 more source

Pharmacokinetic study of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement product

BMC Pharmacology and Toxicology, 2020
Background A novel, high bioavailability oral, enteric coated tablet formulation of S-adenosylmethionine (MSI-195) has been developed for life science application.
Beth R. Cameron, Ludvina Ferreira, I. David MacDonald   +2 more
doaj   +1 more source

Identification of hub methylated‐CpG sites and associated genes in oral squamous cell carcinoma

Cancer Medicine, 2020
To improve personalized diagnosis and prognosis for oral squamous cell carcinoma (OSCC) by identification of hub methylated‐CpG sites and associated genes, weighted gene comethylation network analysis (WGCNA) was performed to examine and identify hub ...
Yuxin Dai, Qiaoli Lv, Tingting Qi, Jian Qu, Hongli Ni, Yongkang Liao, Peng Liu, Qiang Qu   +7 more
doaj   +1 more source

Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel [PDF]

, 2014
Arginine methylation is a novel post-translational modification within the voltage-gated ion channel superfamily, including the cardiac sodium channel, Naᵥ1.5.
Beltran-Alvarez, Pedro, Brugada, Ramon, Díaz-Hernández, Rubí, Feixas, Ferran, Osuna, Sílvia, Pagans, Sara   +5 more
core   +2 more sources

Molecular signatures identified by integrating gene expression and methylation in non-seminoma and seminoma of testicular germ cell tumours

Epigenetics, 2021
Testicular germ cell tumours (TGCTs) are the most common cancer in young male adults (aged 15 to 40). Unlike most other cancer types, identification of molecular signatures in TGCT has rarely reported.
Saurav Mallik, Guimin Qin, Peilin Jia, Zhongming Zhao   +3 more
doaj   +1 more source

Decitabine impact on the endocytosis regulator RhoA, the folate carriers RFC1 and FOLR1, and the glucose transporter GLUT4 in human tumors. [PDF]

, 2014
BackgroundIn 31 solid tumor patients treated with the demethylating agent decitabine, we performed tumor biopsies before and after the first cycle of decitabine and used immunohistochemistry (IHC) to assess whether decitabine increased expression of ...
A Kumari, AS Yang, C Festuccia, C Zeller, CA Stidley, CJ Piyathilake, D Ma, D Matei, D Shang, DJ Stewart, DJ Stewart, DJ Stewart, DJ Stewart, DJ Stewart, DJ Stewart, DW Shen, E Gordian, E San Jose-Eneriz, EA Braga, F Crea, F Fang, H Iwata, H Kantarjian, H Kroeger, HM Kantarjian, J Charlet, J Shia, JA Plumb, JP Issa, JP Issa, JS Kim, K Ghoshal, K Onda, K Ramachandran, K Tikoo, KY Tse, L Ding, L Rothem, MA Kane, ML Orta, NH Nabilsi, R Zhao, RH Finnell, S Fu, S Vijayaraghavalu, SB Baylin, SS Muerkoster, T Tanaka, TB Lee, VF Chekhun, X Chang, XJ Liang, Y Li, Y Oki, Y Zhang, ZG Liu   +55 more
core   +2 more sources

Plants regenerated from tissue culture contain stable epigenome changes in rice. [PDF]

, 2013
Most transgenic crops are produced through tissue culture. The impact of utilizing such methods on the plant epigenome is poorly understood. Here we generated whole-genome, single-nucleotide resolution maps of DNA methylation in several regenerated rice ...
Bellizzi, Maria, Ding, Bo, Feng, Suhua, Jacobsen, Steven E, Meyers, Blake C, Pellegrini, Matteo, Simon, Stacey A, Stroud, Hume, Wang, Guo-Liang   +8 more
core   +2 more sources

Co-targeting RNA Polymerases IV and V Promotes Efficient De Novo DNA Methylation in Arabidopsis. [PDF]

, 2019
The RNA-directed DNA methylation (RdDM) pathway in plants controls gene expression via cytosine DNA methylation. The ability to manipulate RdDM would shed light on the mechanisms and applications of DNA methylation to control gene expression.
Chory, Joanne, Feng, Suhua, Gallego-Bartolomé, Javier, Gardiner, Jason, Ghoshal, Basudev, Jacobsen, Steven E, Kuo, Peggy Hsuanyu, Liu, Wanlu, Park, Soo Young, Zhao, Jenny Miao-Chi   +9 more
core   +2 more sources