Results 1 to 10 of about 892,709 (358)

Methylation of Replicating and Nonreplicating DNA in the Ciliate \u3cem\u3eTetrahymena thermophila\u3c/em\u3e [PDF]

, 1989
Methylation of adenine in replicating and nonreplicating DNA of the ciliate Tetrahymena thermophila was examined. In growing cells, 87% of the methylation occurred on the newly replicated daughter strand, but methylation was also detectable on the ...
Harrison, Gail Singer, Karrer, Kathleen M.   +1 more
core   +1 more source

DNA methylation and DNA methyltransferases [PDF]

, 2017
The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the number of protein-encoding ...
Bestor, Timothy H, Boulard, Mathieu, Edwards, John R, Yarychkivska, Olya   +3 more
core   +3 more sources

Magic methylation with methyl-containing peroxides

Chemical Science
Methyl groups are abundant in pharmaceuticals, and their installation has garnered significant attention. This review summarises advancements in the use of methyl-containing peroxides as reagents for a variety of methylation reactions.
Daliah Farajat, Yuhua Zhang, Chao-Jun Li
openaire   +2 more sources

Stability of Blood DNA Methylation Across Two Timepoints in Three Cohorts

Biomedicines
Background: DNA methylation mediates the gene–environment interactions, with implications for health and disease. Studies with sampling at more than one timepoint revealed the considerable variability of the blood methylome, but comprehensive resources ...
Mikołaj Danielewski, Jarosław Walkowiak, Karolina Wielgus, Jan Krzysztof Nowak   +3 more
doaj   +1 more source

Methylation of the imprinted GNAS1 gene in cell-free plasma DNA : equal steady-state quantities of methylated and unmethylated DNA in plasma [PDF]

, 2008
Background Genomic DNA sequences in cell-free plasma are biomarkers of cancer prognosis, where characteristic changes in methylation of tumour suppressor or oncogene DNA regions are indicative of changes in gene activity.
Alberry, Anker, Bauer, Bianchi, Birch, Chim, Deligezer, Eggermann, Francesco Crea, Grunau, Honda, Jahr, Januchowski, Kamaljit Chatha, Kawakami, Li, Lo, Lui, Robert W. Old, Selina Elsenheimer, Sorenson, Stroun, Stroun, Tsang, Van der Schoot, Vasioukhin, William M. Puszyk   +26 more
core   +1 more source

Epigenetic Therapies in Melanoma—Targeting DNA Methylation and Histone Modification

Biomedicines
Skin cancer prevalence has increased during the last decades, with the last years serving as a pivotal moment for comprehending its epidemiological patterns and its impact on public health.
Adrian Bogdan Tigu, Andrei Ivancuta, Andrada Uhl, Alexandru Cristian Sabo, Madalina Nistor, Ximena-Maria Mureșan, Diana Cenariu, Tanase Timis, Doru Diculescu, Diana Gulei   +9 more
doaj   +1 more source

Search for differentially methylated regions in ancient and modern genomes

Вавиловский журнал генетики и селекции, 2023
Currently, active research is focused on investigating the mechanisms that regulate the development of various pathologies and their evolutionary dynamics. Epigenetic mechanisms, such as DNA methylation, play a significant role in evolutionary processes,
D. D. Borodko, S. V. Zhenilo, F. S. Sharko   +2 more
doaj   +1 more source

DNA methylation at the DAT promoter and risk for psychopathology. Intergenerational transmission between school-age youths and their parents in a community sample [PDF]

, 2018
Background: The effect of gene polymorphisms and promoter methylation, associated with maladaptive developmental outcomes, vary depending on environmental factors (e.g., parental psychopathology).
Claudio D’Addario, Claudio D’Addario, Eleonora Marzilli, Esterina Pascale, Giulia Ballarotto, Luca Cerniglia, Renata Tambelli, Silvia Cimino, Walter Adriani, Walter Adriani   +9 more
core   +2 more sources

Methylation of DNA [PDF]

The Journal of General Physiology, 1966
The methylated bases of DNA are formed by the transfer of the methyl group from S-adenosylmethionine to a polynucleotide acceptor. This transfer is catalyzed by highly specific enzymes which recognize a limited number of available sites in the DNA. The mechanism for the recognition is presently unknown.
M, Gold, M, Gefter, R, Hausmann, J, Hurwitz   +3 more
openaire   +2 more sources

Association of DNA Promoter Methylation and BRAF Mutation in Thyroid Cancer

Current Oncology, 2023
The BRAF V600E mutation and DNA promoter methylation play important roles in the pathogenesis of thyroid cancer (TC). However, the association of these genetic and epigenetic alterations is not clear.
Farzana Jasmine, Briseis Aschebrook-Kilfoy, Mohammad M. Rahman, Garrett Zaagman, Raymon H. Grogan, Mohammed Kamal, Habibul Ahsan, Muhammad G. Kibriya   +7 more
doaj   +1 more source