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Protein post-translational modification in SARS-CoV-2 and host interaction

open access: yesFrontiers in Immunology, 2023
SARS-CoV-2 can cause lung diseases, such as pneumonia and acute respiratory distress syndrome, and multi-system dysfunction. Post-translational modifications (PTMs) related to SARS-CoV-2 are conservative and pathogenic, and the common PTMs are ...
Nana Cheng   +8 more
doaj   +1 more source

Methyl 2-methyl-3,5-dinitrobenzoate [PDF]

open access: yesActa Crystallographica Section E Structure Reports Online, 2010
In the title compound, C(9)H(8)N(2)O(6), the methyl ester group is almost planar (r.m.s. deviation = 0.002 Å) and is oriented at a dihedral angle of 24.27 (16) ° with respect to the benzene ring. The nitro groups make dihedral angles of 4.2 (5) ° and 60.21 (11) ° with the benzene ring.
Rizwan Raza   +4 more
openaire   +3 more sources

Methyl 4-methylbenzoate [PDF]

open access: yesActa Crystallographica Section E Structure Reports Online, 2008
The structure of the title compound, C(9)H(10)O(2), is related to that of 4-methyl-phenyl 4-methyl-benzoate and ethyl-ene di-4-methyl-benzoate showing similar bond parameters. The mol-ecule is planar, the dihedral angle between the aromatic ring and the -COOMe group being 0.95 (6)°. The cystal structure exhibits inter-molecular C-H⋯O contacts that link
Ulrich Flörke   +2 more
openaire   +3 more sources

Genetic plasma biomarkers associated with ischemic stroke

open access: yesExploration of Neuroscience, 2023
Aim: Stroke is one of the leading causes of death and disability worldwide. Plasma biomarkers have long been used to evaluate physiological or pathological processes and to make predictions about the outcome of stroke patients.
Mihai Andrei Ruscu   +8 more
doaj   +1 more source

Epigenetic associations with adolescent grey matter maturation and cognitive development

open access: yesFrontiers in Genetics, 2023
Introduction: Adolescence, a critical phase of human neurodevelopment, is marked by a tremendous reorganization of the brain and accompanied by improved cognitive performance. This development is driven in part by gene expression, which in turn is partly
Dawn Jensen   +15 more
doaj   +1 more source

Pharmacokinetic study of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement product

open access: yesBMC Pharmacology and Toxicology, 2020
Background A novel, high bioavailability oral, enteric coated tablet formulation of S-adenosylmethionine (MSI-195) has been developed for life science application.
Beth R. Cameron   +2 more
doaj   +1 more source

Methyl eucomate [PDF]

open access: yesActa Crystallographica Section E Structure Reports Online, 2008
THE CRYSTAL STRUCTURE OF THE TITLE COMPOUND [SYSTEMATIC NAME: methyl 3-carboxy-3-hydr-oxy-3-(4-hydroxy-benz-yl)propanoate], C(12)H(14)O(6), is stabilized by inter-molecular O-H⋯O and C-H⋯O hydrogen bonds. The mol-ecules are arranged in layers, parallel to (001), which are inter-connected by the O-H⋯O hydrogen bonds.
Linglin Li   +2 more
openaire   +3 more sources

Identification of hub methylated‐CpG sites and associated genes in oral squamous cell carcinoma

open access: yesCancer Medicine, 2020
To improve personalized diagnosis and prognosis for oral squamous cell carcinoma (OSCC) by identification of hub methylated‐CpG sites and associated genes, weighted gene comethylation network analysis (WGCNA) was performed to examine and identify hub ...
Yuxin Dai   +7 more
doaj   +1 more source

Co-targeting RNA Polymerases IV and V Promotes Efficient De Novo DNA Methylation in Arabidopsis. [PDF]

open access: yes, 2019
The RNA-directed DNA methylation (RdDM) pathway in plants controls gene expression via cytosine DNA methylation. The ability to manipulate RdDM would shed light on the mechanisms and applications of DNA methylation to control gene expression.
Chory, Joanne   +9 more
core   +2 more sources

Molecular signatures identified by integrating gene expression and methylation in non-seminoma and seminoma of testicular germ cell tumours

open access: yesEpigenetics, 2021
Testicular germ cell tumours (TGCTs) are the most common cancer in young male adults (aged 15 to 40). Unlike most other cancer types, identification of molecular signatures in TGCT has rarely reported.
Saurav Mallik   +3 more
doaj   +1 more source

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