Results 1 to 10 of about 877,668 (339)

DNA methylation analysis of WIF1 and DKK4 in cervical precancerous lesions and cancer

Journal of Education, Health and Sport, 2019
Epigenetic gene silencing by excessive methylation was found in many tumors. Methylation of tumor suppressor genes is often found in cervical cancer, which is an important pathogenetic factor of oncologic process.
I. Gladchuk, N. Rozhkovska, N. Kashtalian, A. Volyanska, G. Lavrynenko   +4 more
doaj   +3 more sources

Protein post-translational modification in SARS-CoV-2 and host interaction

Frontiers in Immunology, 2023
SARS-CoV-2 can cause lung diseases, such as pneumonia and acute respiratory distress syndrome, and multi-system dysfunction. Post-translational modifications (PTMs) related to SARS-CoV-2 are conservative and pathogenic, and the common PTMs are ...
Nana Cheng, Nana Cheng, Mingzhu Liu, Wanting Li, BingYue Sun, Dandan Liu, Guoqing Wang, Jingwei Shi, Lisha Li   +8 more
doaj   +1 more source

Methyl 2-methyl-3,5-dinitrobenzoate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
In the title compound, C(9)H(8)N(2)O(6), the methyl ester group is almost planar (r.m.s. deviation = 0.002 Å) and is oriented at a dihedral angle of 24.27 (16) ° with respect to the benzene ring. The nitro groups make dihedral angles of 4.2 (5) ° and 60.21 (11) ° with the benzene ring.
Rizwan Raza, Aisha Saddiqa, Muhammad Nawaz Tahir, Muhammad Danish, Mohammad S. Iqbal   +4 more
openaire   +3 more sources

Methyl 4-methylbenzoate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2008
The structure of the title compound, C(9)H(10)O(2), is related to that of 4-methyl-phenyl 4-methyl-benzoate and ethyl-ene di-4-methyl-benzoate showing similar bond parameters. The mol-ecule is planar, the dihedral angle between the aromatic ring and the -COOMe group being 0.95 (6)°. The cystal structure exhibits inter-molecular C-H⋯O contacts that link
Ulrich Flörke, Hummera Rafique, Aamer Saeed   +2 more
openaire   +3 more sources

Genetic plasma biomarkers associated with ischemic stroke

Exploration of Neuroscience, 2023
Aim: Stroke is one of the leading causes of death and disability worldwide. Plasma biomarkers have long been used to evaluate physiological or pathological processes and to make predictions about the outcome of stroke patients.
Mihai Andrei Ruscu, Daiana Burdusel, Andreea-Mihaela Cercel, Madalina Aldea, Dirk M. Hermann, Israel Fernandez Cadenas, Thorsten R. Doeppner, Roxana Surugiu, Aurel Popa-Wagner   +8 more
doaj   +1 more source

Epigenetic associations with adolescent grey matter maturation and cognitive development

Frontiers in Genetics, 2023
Introduction: Adolescence, a critical phase of human neurodevelopment, is marked by a tremendous reorganization of the brain and accompanied by improved cognitive performance. This development is driven in part by gene expression, which in turn is partly
Dawn Jensen, Dawn Jensen, Jiayu Chen, Jiayu Chen, Jessica A. Turner, Jessica A. Turner, Julia M. Stephen, Yu-Ping Wang, Tony W. Wilson, Vince D. Calhoun, Vince D. Calhoun, Vince D. Calhoun, Vince D. Calhoun, Vince D. Calhoun, Jingyu Liu, Jingyu Liu   +15 more
doaj   +1 more source

Pharmacokinetic study of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement product

BMC Pharmacology and Toxicology, 2020
Background A novel, high bioavailability oral, enteric coated tablet formulation of S-adenosylmethionine (MSI-195) has been developed for life science application.
Beth R. Cameron, Ludvina Ferreira, I. David MacDonald   +2 more
doaj   +1 more source

Methyl eucomate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2008
THE CRYSTAL STRUCTURE OF THE TITLE COMPOUND [SYSTEMATIC NAME: methyl 3-carboxy-3-hydr-oxy-3-(4-hydroxy-benz-yl)propanoate], C(12)H(14)O(6), is stabilized by inter-molecular O-H⋯O and C-H⋯O hydrogen bonds. The mol-ecules are arranged in layers, parallel to (001), which are inter-connected by the O-H⋯O hydrogen bonds.
Linglin Li, Guang-Xiong Zhou, Ren-Wang Jiang   +2 more
openaire   +3 more sources

Identification of hub methylated‐CpG sites and associated genes in oral squamous cell carcinoma

Cancer Medicine, 2020
To improve personalized diagnosis and prognosis for oral squamous cell carcinoma (OSCC) by identification of hub methylated‐CpG sites and associated genes, weighted gene comethylation network analysis (WGCNA) was performed to examine and identify hub ...
Yuxin Dai, Qiaoli Lv, Tingting Qi, Jian Qu, Hongli Ni, Yongkang Liao, Peng Liu, Qiang Qu   +7 more
doaj   +1 more source

Decitabine impact on the endocytosis regulator RhoA, the folate carriers RFC1 and FOLR1, and the glucose transporter GLUT4 in human tumors. [PDF]

, 2014
BackgroundIn 31 solid tumor patients treated with the demethylating agent decitabine, we performed tumor biopsies before and after the first cycle of decitabine and used immunohistochemistry (IHC) to assess whether decitabine increased expression of ...
A Kumari, AS Yang, C Festuccia, C Zeller, CA Stidley, CJ Piyathilake, D Ma, D Matei, D Shang, DJ Stewart, DJ Stewart, DJ Stewart, DJ Stewart, DJ Stewart, DJ Stewart, DW Shen, E Gordian, E San Jose-Eneriz, EA Braga, F Crea, F Fang, H Iwata, H Kantarjian, H Kroeger, HM Kantarjian, J Charlet, J Shia, JA Plumb, JP Issa, JP Issa, JS Kim, K Ghoshal, K Onda, K Ramachandran, K Tikoo, KY Tse, L Ding, L Rothem, MA Kane, ML Orta, NH Nabilsi, R Zhao, RH Finnell, S Fu, S Vijayaraghavalu, SB Baylin, SS Muerkoster, T Tanaka, TB Lee, VF Chekhun, X Chang, XJ Liang, Y Li, Y Oki, Y Zhang, ZG Liu   +55 more
core   +2 more sources