Results 1 to 10 of about 483,334 (150)

Protein post-translational modification in SARS-CoV-2 and host interaction

Frontiers in Immunology, 2023
SARS-CoV-2 can cause lung diseases, such as pneumonia and acute respiratory distress syndrome, and multi-system dysfunction. Post-translational modifications (PTMs) related to SARS-CoV-2 are conservative and pathogenic, and the common PTMs are ...
Nana Cheng, Nana Cheng, Mingzhu Liu, Wanting Li, BingYue Sun, Dandan Liu, Guoqing Wang, Jingwei Shi, Lisha Li   +8 more
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Genetic plasma biomarkers associated with ischemic stroke

Exploration of Neuroscience, 2023
Aim: Stroke is one of the leading causes of death and disability worldwide. Plasma biomarkers have long been used to evaluate physiological or pathological processes and to make predictions about the outcome of stroke patients.
Mihai Andrei Ruscu, Daiana Burdusel, Andreea-Mihaela Cercel, Madalina Aldea, Dirk M. Hermann, Israel Fernandez Cadenas, Thorsten R. Doeppner, Roxana Surugiu, Aurel Popa-Wagner   +8 more
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Epigenetic associations with adolescent grey matter maturation and cognitive development

Frontiers in Genetics, 2023
Introduction: Adolescence, a critical phase of human neurodevelopment, is marked by a tremendous reorganization of the brain and accompanied by improved cognitive performance. This development is driven in part by gene expression, which in turn is partly
Dawn Jensen, Dawn Jensen, Jiayu Chen, Jiayu Chen, Jessica A. Turner, Jessica A. Turner, Julia M. Stephen, Yu-Ping Wang, Tony W. Wilson, Vince D. Calhoun, Vince D. Calhoun, Vince D. Calhoun, Vince D. Calhoun, Vince D. Calhoun, Jingyu Liu, Jingyu Liu   +15 more
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Pharmacokinetic study of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement product

BMC Pharmacology and Toxicology, 2020
Background A novel, high bioavailability oral, enteric coated tablet formulation of S-adenosylmethionine (MSI-195) has been developed for life science application.
Beth R. Cameron, Ludvina Ferreira, I. David MacDonald   +2 more
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Identification of hub methylated‐CpG sites and associated genes in oral squamous cell carcinoma

Cancer Medicine, 2020
To improve personalized diagnosis and prognosis for oral squamous cell carcinoma (OSCC) by identification of hub methylated‐CpG sites and associated genes, weighted gene comethylation network analysis (WGCNA) was performed to examine and identify hub ...
Yuxin Dai, Qiaoli Lv, Tingting Qi, Jian Qu, Hongli Ni, Yongkang Liao, Peng Liu, Qiang Qu   +7 more
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Molecular signatures identified by integrating gene expression and methylation in non-seminoma and seminoma of testicular germ cell tumours

Epigenetics, 2021
Testicular germ cell tumours (TGCTs) are the most common cancer in young male adults (aged 15 to 40). Unlike most other cancer types, identification of molecular signatures in TGCT has rarely reported.
Saurav Mallik, Guimin Qin, Peilin Jia, Zhongming Zhao   +3 more
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DNA methylation profiles unique to Kalahari KhoeSan individuals

Epigenetics, 2021
Genomes of KhoeSan individuals of the Kalahari Desert provide the greatest understanding of single nucleotide diversity in the human genome. Compared with individuals in industrialized environments, the KhoeSan have a unique foraging and hunting ...
Alexander Goncearenco, Brenna A. LaBarre, Hanna M. Petrykowska, Weerachai Jaratlerdsiri, M. S. Riana Bornman, Stephen D. Turner, Vanessa M. Hayes, Laura Elnitski   +7 more
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Differential methylation pattern in pubertal girls associated with biochemical premature adrenarche

Epigenetics, 2023
Biochemical premature adrenarche is defined by elevated serum DHEAS [≥40 μg/dL] before age 8 y in girls. This condition is receiving more attention due to its association with obesity, hyperinsulinemia, dyslipidemia, and polycystic ovary syndrome ...
Diana Ponce, Fernando Rodríguez, José P. Miranda, Alexandra M. Binder, José L. Santos, Karin B. Michels, Gordon B. Cutler, Ana Pereira, Germán Iñiguez, Verónica Mericq   +9 more
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Exercise effects on DNA methylation in EVL, CDKN2A (p14, ARF), and ESR1 in colon tissue from healthy men and women

Epigenetics, 2022
Physical activity reduces risk of colon cancer by 20–30%. Aberrant methylation patterns are common epigenetic alterations in colorectal adenomas, and cancers and play a role in cancer initiation and progression.
Catherine Duggan, Ming Yu, Amber R. Willbanks, Jean de Dieu Tapsoba, Ching-Yun Wang, William M. Grady, Anne McTiernan   +6 more
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Lysine 68 Methylation‐Dependent SOX9 Stability Control Modulates Chondrogenic Differentiation in Dental Pulp Stem Cells

Advanced Science, 2023
Dental pulp stem cells (DPSCs), characterized by easy availability, multi‐lineage differentiation ability, and high proliferation ability, are ideal seed cells for cartilage tissue engineering.
Qiannan Sun, Zimeng Zhuang, Rushui Bai, Jie Deng, Tianyi Xin, Yunfan Zhang, Qian Li, Bing Han   +7 more
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