Results 31 to 40 of about 25,402 (289)

AHR and GPER mediate the stimulatory effects induced by 3-methylcholanthrene in breast cancer cells and cancer-associated fibroblasts (CAFs)

Journal of Experimental & Clinical Cancer Research, 2019
Background The chemical carcinogen 3-methylcholanthrene (3MC) binds to the aryl hydrocarbon receptor (AHR) that regulates the expression of cytochrome P450 (CYP) enzymes as CYP1B1, which is involved in the oncogenic activation of environmental pollutants
Francesca Cirillo, Rosamaria Lappano, Leonardo Bruno, Bruno Rizzuti, Fedora Grande, Rita Guzzi, Sara Briguori, Anna Maria Miglietta, Miki Nakajima, Maria Teresa Di Martino, Marcello Maggiolini   +10 more
doaj   +1 more source

A Critical Role for Natural Killer T Cells in Immunosurveillance of Methylcholanthrene-induced Sarcomas

Journal of Experimental Medicine, 2002
Natural killer (NK) T cells initiate potent antitumor responses when stimulated by exogenous factors such as interleukin (IL)-12 or α-galactosylceramide (α-GalCer), however, it is not clear whether this reflects a physiological role for these cells in ...
N. Crowe, M. Smyth, D. Godfrey
semanticscholar   +1 more source

Identification and editing of stem-like cells in methylcholanthrene-induced sarcomas

OncoImmunology, 2019
The cancer stem cell (CSC) paradigm posits that specific cells within a tumor, so-called CSC-like cells, have differing levels of tumorigenicity and chemoresistance.
Emilie T. E. Gross, Carlos D. Peinado, Yujin Jung, Semi Han, Beichen Liu, Endi K. Santosa, Jack D. Bui   +6 more
doaj   +1 more source

3-methylcholanthrene induces differential recruitment of aryl hydrocarbon receptor to human promoters.

Toxicological Sciences, 2010
The aryl hydrocarbon receptor (AHR) is a ligand-activated protein that mediates the toxic actions of polycyclic aromatic and halogenated compounds. Identifying genes directly regulated by AHR is important in understanding the pathways regulated by this ...
Andrea Pansoy, S. Ahmed, Eivind Valen, A. Sandelin, J. Matthews   +4 more
semanticscholar   +1 more source

Testing the theory of immune selection in cancers that break the rules of transplantation [PDF]

, 2009
Modification of cancer cells likely to reduce their immunogenicity, including loss or down-regulation of MHC molecules, is now well documented and has become the main support for the concept of immune surveillance.
A Garcia-Lora, A Scheffold, AF Setiadi, AM Pearse, Ariberto Fassati, B Comin-Anduix, B Kavanagh, B Muller-Hilke, C Murgia, CA Rebbeck, CC Chang, CL Yauk, CM Gonzalez, CM Koebel, CY Lin, D Cohen, D Cohen, D Cohen, D Cohen, E Ambrosino, E Klein, E Mozos, ED Carosella, ED Carosella, EK Geissler, FR Depontieu, G Willimsky, GD Snell, GP Dunn, GP Dunn, GP Dunn, H Ikeda, H McCallum, H Wajant, HV Siddle, HV Siddle, I Kryczek, J Galon, J Hori, J Perez, J Zhou, K Kretschmer, K Masuda, K Milne, KJ Malmberg, KL Wright, L Tian, L Vago, L Yip, M Bleakley, M Campoli, M Gerloni, M Mammolenti, M Mehling, M Novinski, M Pierobon, M Shackleton, M Thornley, MA Cheever, MN Scherer, N Mitchison, N Schwinn, N. Avrion Mitchison, NA Mitchison, NM Moutsopoulos, P Jimenez, PC Chou, R Mendez, R Mendez, R Uppaluri, S Lob, S Verheyden, SM Kang, SR Choudhury, T Akagi, T Cabrera, T Isoda, T Marchal, T Rodriguez, TJ Yang, TJ Yang, W Reith, YC Chang, YW Hsiao, YW Hsiao   +84 more
core   +2 more sources

Targeting cytokine signaling checkpoint CIS activates NK cells to protect from tumor initiation and metastasis

OncoImmunology, 2017
The cytokine-induced SH2-containing protein CIS belongs to the suppressor of cytokine signaling (SOCS) protein family. Here, we show the critical role of CIS in suppressing natural killer (NK) cell control of tumor initiation and metastasis.
Eva M. Putz, Camille Guillerey, Kevin Kos, Kimberley Stannard, Kim Miles, Rebecca B. Delconte, Kazuyoshi Takeda, Sandra E. Nicholson, Nicholas D. Huntington, Mark J. Smyth   +9 more
doaj   +1 more source

Isopsoralen Enhanced Osteogenesis by Targeting AhR/ERα

Molecules, 2018
Isopsoralen (IPRN), one of the main effective ingredients in Psoralea corylifolia Linn, has a variety of biological effects, including antiosteoporotic effects.
Luna Ge, Yazhou Cui, Kai Cheng, Jinxiang Han   +3 more
doaj   +1 more source

The Role of Regulatory T Lymphocytes in Immune Control of MC-2 Fibrosarcoma

Acta Clinica Croatica, 2020
The role of T regulatory lymphocytes (Treg) particularly in cancer is well known. The goal of the present study was to determine the contribution of these lymphocytes in the regulation of anti-tumor immunity of CBA/HZgr mice against MC-2 fibrosarcoma ...
Tomislav Jukić, Ana Jurin Martić, Siniša Ivanković, Mariastefania Antica, Doroteja Pavan Jukić, Cecilija Rotim, Mislav Jurin   +6 more
doaj   +1 more source

GFP transgenic medaka (Oryzias latipes) under the inducible cyp1a promoter provide a sensitive and convenient biological indicator for the presence of TCDD and other persistent organic chemicals. [PDF]

PLoS ONE, 2013
Persistent organic pollutants (POPs) are resistant to environmental degradation and can cause multitude of health problems. Cytochrome P450 1A (Cyp1a) is often up-regulated by POPs through the activation of aryl hydrocarbon receptor (AhR) pathway and is ...
Grace Hwee Boon Ng, Zhiyuan Gong
doaj   +1 more source

Influence of thyroid secretion on the in­duction of leukemia in Dba mice by methylcholanthrene [PDF]

, 1960
1) The influence of thyroid secretion upon the induction of leukemia in Dba/2 male mice by methylcholanthrene was investigated. Radiothyroidectomy significantly reduced the incidence of leukemia in these mice. This reduction in incidence did not occur if
Ida, Noriaki, Oda, Nobuo
core   +1 more source