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Screening of Metabolites and Metabolic Pathways in Five Different <i>Ocimum</i> Species From the Same Origin Using GC-MS. [PDF]
Biochem Res IntJaiswal RP +5 more
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Methyleugenol as a surgical anesthetic in rodents
Experientia, 1981The in vivo administration of 59Fe to the rat accompanied by acetylsalicylic acid (ASA) enhanced significantly counts in blood, spleen, liver and femur without affecting those of the intestine. The results suggest that ASA augments iron absorption either via an inhibitory action on the synthesis of prostaglandins or by a purely chemical mechanism.
Carlini, E. A. +2 more
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Journal of Agricultural and Food Chemistry, 2018
Methyleugenol (ME), a natural ingredient of several herbs and spices used in the human diet, is hepatocarcinogenic in rodents. Following metabolic activation to the reactive carbocation intermediate, ME can bind covalently to DNA, which is directly associated with its carcinogenicity.
Yukun Feng +4 more
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Methyleugenol (ME), a natural ingredient of several herbs and spices used in the human diet, is hepatocarcinogenic in rodents. Following metabolic activation to the reactive carbocation intermediate, ME can bind covalently to DNA, which is directly associated with its carcinogenicity.
Yukun Feng +4 more
openaire +2 more sources
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2000
Methyleugenol is a substituted alkenylbenzene found in a variety of foods, products, and essential oils. In a 2-year bioassay conducted by the National Toxicology Program, methyleugenol caused neoplastic lesions in the livers of Fischer 344 rats and B6C3F(1) mice. We were interested in the cytotoxicity and genotoxicity caused by methyleugenol and other
J L, Burkey +3 more
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Methyleugenol is a substituted alkenylbenzene found in a variety of foods, products, and essential oils. In a 2-year bioassay conducted by the National Toxicology Program, methyleugenol caused neoplastic lesions in the livers of Fischer 344 rats and B6C3F(1) mice. We were interested in the cytotoxicity and genotoxicity caused by methyleugenol and other
J L, Burkey +3 more
openaire +2 more sources
Constituents of aromatic plants: I. Methyleugenol
Fitoterapia, 2000Methyleugenol (ME) is a natural constituent of the essential oils of a number of plants widely used in foodstuffs as flavouring agents. Its occurrence, routes of intake, and available information on toxicity, kinetics and metabolism are reviewed. In view of the carcinogenic potential of ME, the need to check its presence in food products with effective
M, De Vincenzi +3 more
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Food & Function, 2012
Methyleugenol is a substituted alkenylbenzene classified by the European Union's Scientific Committee on Food as a genotoxic carcinogen. We addressed cytotoxicity, genotoxicity and mutagenicity caused by methyleugenol and selected oxidative methyleugenol metabolites in Chinese hamster lung fibroblasts V79 cells.
Isabel Anna Maria, Groh +6 more
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Methyleugenol is a substituted alkenylbenzene classified by the European Union's Scientific Committee on Food as a genotoxic carcinogen. We addressed cytotoxicity, genotoxicity and mutagenicity caused by methyleugenol and selected oxidative methyleugenol metabolites in Chinese hamster lung fibroblasts V79 cells.
Isabel Anna Maria, Groh +6 more
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Methyleugenol in Ocimum basilicum L. Cv. Genovese Gigante
Journal of Agricultural and Food Chemistry, 2000Ocimum basilicum cv. Genovese Gigante is the basil cultivar used the most in the production of a typical Italian sauce called pesto. The aromatic composition of plants at different growth stages was determined. Plants from different areas of northwestern Italy were analyzed at 4 and 6 weeks after sowing and showed methyleugenol and eugenol as the main ...
MIELE M. +3 more
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Methyleugenol hepatocellular cancer initiating effects in rat liver
Food and Chemical Toxicology, 2013Methyleugenol (MEG), a constituent of plants used in the human diet, is hepatocarcinogenic in rodents. In an experiment to elucidate its mode of action in rat liver, male F344 rats were administered MEG intragastrically at 3 doses per week for up to 16 weeks in an initiation phase, after which half the rats were fed 500 ppm phenobarbital (PB) in the ...
Gary M, Williams +3 more
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Anesthetic Action of Methyleugenol and Other Eugenol Derivatives
Pharmacology, 1976A comparative study of four natural eugenol compounds found in the volatile oil fraction of Myristica fragans, namely eugenol (E), methyleugenol (ME), isoeugenol and methylisoeugenol, was carried out in mice. Using a mixture of saline + tween-80 to suspend the compounds and the intraperitoneal route, ME revealed to be the most active and the less toxic
A B, Sell, E A, Carlini
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