Results 161 to 170 of about 292,501 (293)

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

Enhanced Protein Synthesis and Hippocampus‐Dependent Memory via Inhibition of YTHDF2‐Mediated m6A mRNA Degradation

Advanced Science, EarlyView.
YTHDF2‐mediated m6A mRNA decay critically regulates learning and memory. Its forebrain‐specific knockout in mice impedes degradation of m6A‐modified mRNAs, enhancing hippocampal synaptic transmission, protein synthesis, and memory. Conversely, hippocampal YTHDF2 reintroduction or SEMA4B reduction reverses this enhancement, while its overexpression ...
Kuan Li, Chen Guo, Xiaoli Wu, Cuiting Wu, Songfen Wu, Si Su, Min Wu, Xidan Zhou, Si Li, Yihui Cui, Tao Zhou   +10 more
wiley   +1 more source

Toxicity assessment of doxycycline-aided artificial intelligence-assisted drug design targeting candidate 16S rRNA methyltransferase gene. [PDF]

BMC Pharmacol Toxicol
Mubeen H, Rafiq N, Khan M, Jabeen S, Shoaib MW.   +4 more
europepmc   +1 more source

Targeting the Dynamics Between TAMs and CAR‐T Cells in Solid Tumor Therapies

Advanced Science, EarlyView.
This review highlights the critical role of tumor‐associated macrophages (TAMs) in affecting CAR‐T cell therapy effectiveness in solid tumors. TAMs contribute to immune suppression through cytokine secretion, immune checkpoint activation, and metabolic reprogramming, leading to CAR‐T cell exhaustion and reduced efficacy. The article explores strategies
Xiang Zhang, Hao Zheng, Zi‐Chang Liu, Ling‐Jie Luo, Xiao Dong, Xin‐Gang Cui, Yan‐Wei Wu, Liang Chen   +7 more
wiley   +1 more source

Epigenetic Disruption as a Molecular Signature in Idiopathic Nonobstructive Azoospermia. [PDF]

Am J Mens Health
Firouzabadi AM, Harimi S, Heydari P, Demehri F, Mirghanizadeh Bafghi SAH, Fesahat F.   +5 more
europepmc   +1 more source

Catechol-O-methyltransferase 158G/A polymorphism and endometriosis/adenomyosis susceptibility: A meta-analysis in the Chinese population

, 2018
Yongwei Li, Chunxia Wang, Jianshe Chen, Lu Chen, Xiaoqian Zhang, Yue Hu, Xiaobin Niu, Dongxu Pei, Xinwei Liu, Yongyi Bi   +9 more
openalex   +1 more source

Mitochondrial Adaptation to Mechanical Stress in Cardiac Ageing and Disease

Advanced Science, EarlyView.
Mechanical forces shape the heart's energy factories. This review explores how mitochondria in cardiac cells sense and respond to biomechanical stress, altering their structure, positioning, and metabolism. By linking mechanical cues to mitochondrial adaptation, the article highlights pathways driving heart disease and points to new strategies for ...
Aishwarya Prakash, Thomas Iskratsch
wiley   +1 more source

The effects of genetically determined plasma methyltransferases on digestive system cancers: a comprehensive bidirectional two-sample Mendelian randomization analysis. [PDF]

Discov Oncol
Zhang C, Li X, Dong Z, Weng Y, Yu W, Cai X.   +5 more
europepmc   +1 more source

MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

Science, 2016
G. Kryukov, F. H. Wilson, J. Ruth, Joshiawa Paulk, Aviad Tsherniak, Sara E Marlow, F. Vazquez, B. Weir, M. Fitzgerald, Minoru Tanaka, C. Bielski, Justin Scott, C. Dennis, G. Cowley, J. Boehm, D. Root, T. Golub, C. Clish, J. Bradner, W. Hahn, L. Garraway   +20 more
semanticscholar   +1 more source

Dual Suppression of Methanogenesis by Dichloromethane and Salinity: Competitive Methyltransferase Inhibition and Energy-Coupling Disruption

Jieyi Liu, S. Xie, Yatong Ji, Xuan Fan, Sheng‐Nian Luo, Xiangyang Xu, Chen Wang, Liang Zhu   +7 more
openalex   +1 more source