British Journal of Clinical Pharmacology, EarlyView.While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis +5 more
wiley +1 more source
PCIF1 Attenuates Type I Interferon Induction by Inhibiting IRF3 Activation in a Methyltransferase-Independent Manner. [PDF]
CellsKano R +9 more
europepmc +1 more source
Psilocybin Production With Genetically Modified Aspergillus nidulans Under Pressurized Conditions
Biotechnology and Bioengineering, EarlyView.Shake flask cultures of psilocybin‐producing A. nidulans were investigated with respect to nitrogen source, rheology, power input, and oxygen availability, and subsequently scaled to a stirred tank reactor scale based on specific power input to develop and optimize a pressurized bioprocess.
Sophie Weiser +7 more
wiley +1 more source
Optimized Bioconversion of Naringenin to Hesperetin in <i>Escherichia coli</i> With Halide Methyltransferase-Mediated <i>S</i>-Adenosylmethionine Regeneration. [PDF]
Eng Life SciWildhagen M +4 more
europepmc +1 more source
Structure of the restriction-modification controller protein C.Esp1396I [PDF]
, 2009 Ball, Neil J. +3 more
core +1 more source
Enhancing CHO cell recombinant protein production using a perfusion‐directed host evolution approach
Biotechnology Progress, EarlyView.Abstract Clonally derived cell lines generated from Chinese hamster ovary (CHO) cells encounter numerous stressors when cultured in high‐intensity perfusion bioreactors leading to poor process performance. To circumvent this, the ability of CHO cells to adapt to different culture environments was exploited. Here host cells were selected in the presence
Peter Amaya +7 more
wiley +1 more source
Rational Design Strategies for Stimuli‐Responsive DNAzymes Using Modified and Artificial Nucleotides
Chemistry – A European Journal, EarlyView.Activity control of RNA‐cleaving DNAzymes in response to external stimuli has attracted growing interest for applications in DNA‐based diagnostics, therapeutics, and dynamic DNA nanotechnology. This review summarizes rational design strategies for stimuli‐responsive DNAzymes using modified or artificial nucleotides, including split and caged DNAzymes ...
Yusuke Takezawa, Mitsuhiko Shionoya
wiley +1 more source
Evolutionary and Functional Characterization of an Auxin Methyltransferase (<i>CsIAMT</i>) in Cucumber Reveals Its Role in Stress Adaptation and Development. [PDF]
Ecol EvolZhang X +7 more
europepmc +1 more source
Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology
Developmental Dynamics, EarlyView.Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley +1 more source
<i>FTSJ1</i>-mediated <i>IL1RN</i> mRNA instability promotes inflammation-driven hepatocellular carcinoma. [PDF]
J Gastrointest OncolJiang S +7 more
europepmc +1 more source