Results 181 to 190 of about 292,501 (293)

Development of Dimethylsulfonium Probes for Broad Profiling of Methyllysine Reader Proteins

Advanced Science, EarlyView.
Development of oligoglycine‐based dimethylsulfonium probes for unbiased crosslinking to methyllysine readers. The general probe facilitates profiling of site‐specific methyllysine readers, evaluation of selectivity and activity of reader inhibitors, and global profiling of methyllysine readers.
Jinyu Yang, Yihang Xiao, Yingxiao Gao, Mingxuan Wu   +3 more
wiley   +1 more source

Genome-Wide Identification and Expression Pattern Analysis of the DNA Methyltransferase Gene Family Revealed the DNA Methylation Response to Tapping in Rubber Tree. [PDF]

Plants (Basel)
Hao Y, Hu B, Xue Y, Li X, Wang K, Dai X, Guo Z, Long X.   +7 more
europepmc   +1 more source

THE ROLE OF CATECHOL-O-METHYLTRANSFERASE (COMT) AND THE EFFECTS OF COMT INHIBITION IN BRAIN AND IN CARDIOVASCULAR AND RENAL PATHOPHYSIOLOGY

, 2007
Teemu Helkamaa
openalex   +1 more source

Single-molecule Tracking Reveals Multi-state Dynamics of a Bacterial DNA Methyltransferase in Vivo [PDF]

, 2020
Ziyuan Chen, Taylor M. Nye, Lyle A. Simmons, Julie S. Biteen   +3 more
openalex   +1 more source

New Insights Into Changes in the DNA Methylation Pattern of the SHOX Gene in Patients With Léri‐Weill Dyschondrosteosis

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT SHOX gene haploinsufficiency is associated with Léri‐Weill dyschondrosteosis (LWD) or idiopathic short stature (ISS) and could be caused by the structural and point mutations in the coding region and by the deletions in SHOX gene regulatory sequences. The role of the duplications in regulatory sequences is ambivalent.
Valeriia Kopytko, Katerina Hirschfeldova, Pavlina Capkova, Roman Solc   +3 more
wiley   +1 more source

New retron systems from environmental bacteria identify triggers of anti-phage defense and expand tools for genome editing. [PDF]

PLoS Biol
Nakamura KL, Zhang K, Mestre MR, Rojas-Montero M, Shipman SL.   +4 more
europepmc   +1 more source

A Systematic Review of Adverse Childhood Experiences and Epigenetic Age Acceleration in Later Adult Life Measured With Second and Third‐Generation Epigenetic Clocks

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT We examined the relationship between adverse childhood experiences (ACEs) and epigenetic age acceleration (EAA) in adulthood as measured by second and third generation epigenetic clocks by performing a systematic review of the literature. The electronic databases MEDLINE and EMBASE were searched on 17 July 2023.
Matthew Green, Laura Horsfall, Azam Saied   +2 more
wiley   +1 more source

A methyltransferase molecular switch unlocks <i>para</i>-quinone methide generation and oligomerization. [PDF]

Chem Sci
Ma C, Zhang Z, Wang W, Zhang F, Xie A, Zhang K, Ren X, Wang L, Che Q, Zhu T, Zhang J, Li D.   +11 more
europepmc   +1 more source

Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain.

American Journal of Human Genetics, 2004
Jingshan Chen, B. Lipska, N. Halim, Quang D Ma, M. Matsumoto, Samer Melhem, B. Kolachana, T. Hyde, M. Herman, J. Apud, M. Egan, J. Kleinman, D. Weinberger   +12 more
semanticscholar   +1 more source

Molecular Profiling of Genes Associated With Methylphenidate Pathway Therapy and Discovery of New Variants in Amazonian Amerindian Populations

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT In Attention Deficit Hyperactivity Disorder (ADHD), methylphenidate is one of the most widely used drugs, in which patient response significantly impacts prognosis. This study aimed to characterize the molecular profile of 10 genes associated with methylphenidate therapy.
Aline Pasquini Santos, Tatiane Carinta de Souza, Kaio Evandro Cardoso Aguiar, Ana Caroline Alves da Costa, Natasha Monte, Juliana Carla Gomes Rodrigues, Giovanna Gilioli da Costa Nunes, Rita de Cássia Calderaro Coelho, Ândrea Ribeiro‐dos‐Santos, André Maurício Ribeiro dos Santos, Sandro José de Souza, Sidney Emanuel Batista dos Santos, Rommel Mario Rodriguez Burbano, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos   +14 more
wiley   +1 more source