Results 231 to 240 of about 292,501 (293)

Biosynthesis of the Biphenomycin Family of Potent Antibiotics

Angewandte Chemie International Edition, EarlyView.
The complete biosynthetic pathway of the biphenomycin antibiotics is elucidated, revealing a unique enzymatic machinery featuring a bifunctional MNIO, a regioselective arginase, a B12‐dependent rSAM for C,C coupling, hydroxylation enzymology, and a metalloprotease with dual‐specificity.
Elisabeth Strunk, Alfred Lobert, Tatiana Khorovich, Katia M. Guzman Lucio, René Richarz, Maximilian Hohmann, Paul M. D'Agostino, Tobias A. M. Gulder   +7 more
wiley   +1 more source

m⁶A in bone homeostasis and related diseases. [PDF]

Biomater Transl
Ma B, Su J, Zhu Y, Zhang F, Ma H, Sun T, Cheng H, Xu K, Gu B, Wen R, Zheng Y, Yang Q, Wang D, Yu F.   +13 more
europepmc   +1 more source

Homoterpene Biosynthesis in Fungi

Angewandte Chemie International Edition, EarlyView.
The first homoterpene biosynthetic pathway in the fungal kingdom is reported. A methyltransferase–terpene cyclase pair produces a unique heptamethyl bicyclo[3.3.1]nonane homoterpene via presodorifen, demonstrating that homoterpene biosynthesis via the addition of a C1 unit to terpene diphosphate precursors prior to scaffold formation extends beyond the
Lin Zhou, Tatjana Reuter, Kiara Schumann, Markus Mayer, Dominik Matthias Hanauska, Lena Barra   +5 more
wiley   +1 more source

Expanding the Structural Diversity of Polyketides by Exploring the Cofactor Tolerance of an Inline Methyltransferase Domain

, 2013
Jaclyn M. Winter, Grace Chiou, Ian R. Bothwell, Wei Xu, Neil K. Garg, Minkui Luo, Yi Tang   +6 more
openalex   +1 more source

Insight into the mechanisms and dysregulation of KMT5C-H4K20me3 in cancer. [PDF]

Epigenetics
Son J, Kasinski AL.
europepmc   +1 more source

Exploration into the MLL4/WRAD Enzyme-Substrate Network: Systematic In Vitro Identification of CFP1 as a Potential Non-Histone Substrate of the MLL4 Lysine Methyltransferase. [PDF]

Epigenomes
Boulter M, Collins R, Biggar KK.
europepmc   +1 more source

Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives

Journal of Virology, 2016
B. Coutard, K. Barral, J. Lichière, B. Selisko, Baptiste Martin, Wahiba Aouadi, M. O. Lombardía, F. Debart, J. Vasseur, J. Guillemot, B. Canard, E. Decroly   +11 more
semanticscholar   +1 more source

Exploring Advanced Methodologies for NS5 Methyltransferase Targeted Drug Discovery

Tomáš Otava, Matúš Drexler, Petra Krafcikova, Dominika Chalupska, Karel Chalupský, Vaclav Veverka, Evzen Boura, Radim Nencka   +7 more
openalex   +1 more source

DNA (Cytosine-C5) methyltransferase inhibition by oligodeoxyribonucleotides containing 2-(1H)-pyrimidinone (zebularine aglycon) at the enzymatic target site

, 2009
Dana M. van Bemmel, Adam S. Brank, Ramón Eritja, Víctor E. Márquez, Judith K. Christman   +4 more
openalex   +1 more source

Biological cost of aminoglycoside resistance Arm/Kam 16S rRNA methyltransferases from natural antibiotic producers and clinical pathogens. [PDF]

Antimicrob Agents Chemother
Vidučić D, Obranić S, Matovina M, Babić F, Maravić-Vlahoviček G.   +4 more
europepmc   +1 more source