Results 221 to 230 of about 124,916 (340)

H3K9 methyltransferase G9a and the related molecule GLP [PDF]

, 2011
Yoichi Shinkai, Makoto Tachibana
openalex   +1 more source

A Riboflavin‐Derived Flavinium Salt Mediates Chemoselective Methylation Reactions

Chemistry – A European Journal, EarlyView.
A two‐component methylation protocol was developed, where the active flavin mediator can be recycled in a single step. Crystallographic data and NMR spectroscopy support the mechanistic proposal, while chemoselective methylation was observed for a broad range of biologically relevant substrates. ABSTRACT Selective methylation is among the most relevant
Tim Langschwager, Ekrem Suylu, Julian Zuber, Golo Storch   +3 more
wiley   +1 more source

Design, Synthesis, and Evaluation of Novel Inhibitors of Aminoglycoside-Resistance 16S Ribosomal RNA Methyltransferases. [PDF]

ChemMedChem
Deprez BE, Dey D, Zelinskaya N, Csatary EE, Yang QW, Nie M, Conn GL, Wuest WM.   +7 more
europepmc   +1 more source

Mechanisms of Resistance to Cancer Immunotherapy: A Host–Tumor Interaction Perspective; A Review Article

Cancer Nexus, EarlyView.
Mechanisms of resistance to cancer immunotherapy from a host–tumor interaction perspective. The central tumor cell is protected by multiple resistance mechanisms, including genetic mutations, epigenetic modifications, and metabolic alterations. The immunosuppressive tumor microenvironment features myeloid‐derived suppressor cells (MDSCs), regulatory T ...
Mohammed Elmujtba Adam Essa, Hamid Noori, Abdelkareem A. Ahmed   +2 more
wiley   +1 more source

Phospho-Switch: Regulation of the Activity of SAM-Dependent Methyltransferases Using <i>H</i>-Phosphinic SAM Analogue. [PDF]

Int J Mol Sci
Filonov VL, Khomutov MA, Rudenko AY, Mariasina SS, Ozhiganov RM, Sergeev AV, Kochetkov SN, Polshakov VI, Gromova ES, Khandazhinskaya AL, Khomutov AR.   +10 more
europepmc   +1 more source

Protein arginine methyltransferase 5 has prognostic relevance and is a druggable target in multiple myeloma

, 2017
Annamaria Gullà, Teru Hideshima, Giada Bianchi, Mariateresa Fulciniti, Mehmet Samur, Jun Qi, Y-T Tai, Takeshi Harada, Eugenio Morelli, Nicola Amodio, Ruben D. Carrasco, Pierosandro Tagliaferri, Nikhil C. Munshi, Pierfrancesco Tassone, Kenneth C. Anderson   +14 more
openalex   +1 more source

Comparative Bioequivalence and Safety Evaluation of Ibuprofen/Phenylephrine Hydrochloride Fixed‐Dose Combination Tablets in Healthy Chinese Volunteers

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This single‐center, randomized, open‐label bioequivalence program compared two fixed‐dose combination (FDC) tablets containing ibuprofen (200 mg) and phenylephrine hydrochloride (10 mg) from different manufacturers in healthy Chinese adults under fasting and fed conditions. A three‐period, partially replicated crossover design was used for the
Menghan Ye, Rui Zhang, Jing Wan, Jinping Zhou, Pengpeng Guo, Dianwen Yu, Peixia Li, Yani Liu, Shaojun Shi   +8 more
wiley   +1 more source

Unveiling the Role of Histone Methyltransferases in Psoriasis Pathogenesis: Insights from Transcriptomic Analysis. [PDF]

Int J Mol Sci
Romhányi D, Bessenyei Á, Szabó K, Kemény L, Gyulai R, Groma G.   +5 more
europepmc   +1 more source

Expanding the Structural Diversity of Polyketides by Exploring the Cofactor Tolerance of an Inline Methyltransferase Domain

, 2013
Jaclyn M. Winter, Grace Chiou, Ian R. Bothwell, Wei Xu, Neil K. Garg, Minkui Luo, Yi Tang   +6 more
openalex   +1 more source

Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology

Developmental Dynamics, EarlyView.
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley   +1 more source