Results 21 to 30 of about 61,900 (246)

The Role and Mechanism of Lysine Methyltransferase and Arginine Methyltransferase in Kidney Diseases

Frontiers in Pharmacology, 2022
Methylation can occur in both histones and non-histones. Key lysine and arginine methyltransferases under investigation for renal disease treatment include enhancer of zeste homolog 2 (EZH2), G9a, disruptor of telomeric silencing 1-like protein (DOT1L ...
Xun Zhou, Hui Chen, Jinqing Li, Yingfeng Shi, Shougang Zhuang, Shougang Zhuang, Na Liu   +6 more
doaj   +1 more source

Heterologous and High Production of Ergothioneine in Bacillus licheniformis by Using Genes from Anaerobic Bacteria

Metabolites
Purpose: This study aimed to utilize genetically engineered Bacillus licheniformis for the production of ergothioneine (EGT). Given the value of EGT and the application of Bacillus licheniformis in enzyme preparation production, we cloned the key enzymes
Zhe Liu, Fengxu Xiao, Yupeng Zhang, Jiawei Lu, Youran Li, Guiyang Shi   +5 more
doaj   +1 more source

A small molecule inhibitor of leucine carboxyl methyltransferase-1 inhibits cancer cell survival

Frontiers in Drug Discovery
Reversible phosphorylation is the basis for signal transduction in eukaryotic cells, and this is tightly controlled by the complex interplay of kinases and phosphatases.
O. A. Arosarena, O. A. Arosarena, O. A. Arosarena, A. S. Saribas, E. P. Papadopoulos   +4 more
doaj   +1 more source

Histone 3 Methyltransferases Alter Melanoma Initiation and Progression Through Discrete Mechanisms

Frontiers in Cell and Developmental Biology, 2022
Perturbations to the epigenome are known drivers of tumorigenesis. In melanoma, alterations in histone methyltransferases that catalyze methylation at histone 3 lysine 9 and histone 3 lysine 27—two sites of critical post-translational modification—have ...
Sara E. DiNapoli, Sara E. DiNapoli, Raúl Martinez-McFaline, Raúl Martinez-McFaline, Hao Shen, Hao Shen, Ashley S. Doane, Alexendar R. Perez, Akanksha Verma, Amanda Simon, Isabel Nelson, Isabel Nelson, Courtney A. Balgobin, Courtney A. Balgobin, Caitlin T. Bourque, Caitlin T. Bourque, Jun Yao, Jun Yao, Renuka Raman, Renuka Raman, Wendy Béguelin, Wendy Béguelin, Jonathan H. Zippin, Olivier Elemento, Ari M. Melnick, Ari M. Melnick, Yariv Houvras, Yariv Houvras, Yariv Houvras   +28 more
doaj   +1 more source

Characterisation of the Broadly-Specific O-Methyl-transferase JerF from the Late Stages of Jerangolid Biosynthesis

Molecules, 2016
We describe the characterisation of the O-methyltransferase JerF from the late stages of jerangolid biosynthesis. JerF is the first known example of an enzyme that catalyses the formation of a non-aromatic, cyclic methylenolether.
Steffen Friedrich, Franziska Hemmerling, Frederick Lindner, Anna Warnke, Johannes Wunderlich, Gesche Berkhan, Frank Hahn   +6 more
doaj   +1 more source

H3K36 Di-Methylation Marks, Mediated by Ash1 in Complex with Caf1-55 and MRG15, Are Required during Drosophila Heart Development

Journal of Cardiovascular Development and Disease, 2023
Methyltransferases regulate transcriptome dynamics during development and aging, as well as in disease. Various methyltransferases have been linked to heart disease, through disrupted expression and activity, and genetic variants associated with ...
Jun-yi Zhu, Chen Liu, Xiaohu Huang, Joyce van de Leemput, Hangnoh Lee, Zhe Han   +5 more
doaj   +1 more source

Environmental Enrichment Reverses Histone Methylation Changes in the Aged Hippocampus and Restores Age-Related Memory Deficits

Biology, 2015
A decline in long-term memory (LTM) formation is a common feature of the normal aging process, which corresponds with abnormal expression of memory-related genes in the aged hippocampus. Epigenetic modulation of chromatin structure is required for proper
Sarah J. Morse, Anderson A. Butler, Robin L. Davis, Ian J. Soller, Farah D. Lubin   +4 more
doaj   +1 more source

Targeting Viral Methyltransferases: An Approach to Antiviral Treatment for ssRNA Viruses

Viruses, 2022
Methyltransferase enzymes have been associated with different processes within cells and viruses. Specifically, within viruses, methyltransferases are used to form the 5′cap-0 structure for optimal evasion of the host innate immune system. In this paper,
Peter Ramdhan, Chenglong Li
doaj   +1 more source

Critical roles of protein methyltransferases and demethylases in the regulation of embryonic stem cell fate

Epigenetics, 2017
Accumulating evidence has recently shown that protein methyltransferases and demethylases are crucial regulators in either maintaining pluripotent states or inducing differentiation of embryonic stem cells. These enzymes control pluripotent signatures by
Theodore Vougiouklakis, Yusuke Nakamura, Vassiliki Saloura   +2 more
doaj   +1 more source

Incidence of the novel rmtF and rmtG methyltransferases in carbapenem-resistant Enterobacteriaceae from a hospital in India

Journal of Infection in Developing Countries, 2015
This item has no abstract. Follow the links belo to access the full text.
Joel Filgona, Tuhina Banerjee, Shampa Anupurba   +2 more
doaj   +1 more source