Results 31 to 40 of about 61,900 (246)

Histone lysine methyltransferase-related neurodevelopmental disorders: current knowledge and saRNA future therapies

Frontiers in Cell and Developmental Biology, 2023
Neurodevelopmental disorders encompass a group of debilitating diseases presenting with motor and cognitive dysfunction, with variable age of onset and disease severity.
Charlotte Roth, Helena Kilpinen, Helena Kilpinen, Manju A. Kurian, Manju A. Kurian, Serena Barral   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Networking and Specificity-Changing DNA Methyltransferases in Helicobacter pylori

Frontiers in Microbiology, 2020
Epigenetic DNA base methylation plays important roles in gene expression regulation. We here describe a gene expression regulation network consisting of many DNA methyltransferases each frequently changing its target sequence-specificity.
Hirokazu Yano, Hirokazu Yano, Md. Zobaidul Alam, Emiko Rimbara, Tomoko F. Shibata, Masaki Fukuyo, Yoshikazu Furuta, Yoshikazu Furuta, Tomoaki Nishiyama, Shuji Shigenobu, Mitsuyasu Hasebe, Mitsuyasu Hasebe, Atsushi Toyoda, Yutaka Suzuki, Sumio Sugano, Sumio Sugano, Keigo Shibayama, Ichizo Kobayashi, Ichizo Kobayashi, Ichizo Kobayashi, Ichizo Kobayashi, Ichizo Kobayashi   +21 more
doaj   +1 more source

Targets of histone H3 lysine 9 methyltransferases

Frontiers in Cell and Developmental Biology, 2022
Histone H3 lysine 9 di- and trimethylation are well-established marks of constitutively silenced heterochromatin domains found at repetitive DNA elements including pericentromeres, telomeres, and transposons. Loss of heterochromatin at these sites causes
Aidan J. Levinsky, Aidan J. Levinsky, Gregor McEdwards, Gregor McEdwards, Nasha Sethna, Nasha Sethna, Mark A. Currie, Mark A. Currie   +7 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

rRNA methyltransferases and their role in resistance to antibiotics [PDF]

Journal of Medical Biochemistry, 2010
Methyltransferases (MTases), a large protein superfamily, commonly use S-adenosyl-L-methionine (SAM) as the methyl group donor. SAM-dependant MTases methylate both nucleic acids (DNA, RNA) and proteins, and thus modulate their activity, function and ...
Morić Ivana, Savić Miloje, Ilić-Tomić Tatjana, Vojnović Sandra, Bajkić Sanja, Vasiljević Branka   +5 more
doaj  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Photocaged Dinucleoside Tetraphosphates for Light‐Mediated Activation of 5′ Cap Interactions and Translation In Vitro

ChemistryEurope
Dinucleoside tetraphosphates (Np4N) have been reported as 5′ caps of RNAs in bacteria and mammalian cells. The guanosine‐based version (Gp4N) resembles the canonical eukaryotic 5′ cap (m7Gp3N), which is a central platform for cap‐interacting proteins ...
Cedrik Kühling, Wiebke Teich, Bayram Terzi, Helena Schepers, Sabine Hüwel, Andrea Rentmeister   +5 more
doaj   +1 more source