Results 31 to 40 of about 124,916 (340)

The Role and Mechanism of Lysine Methyltransferase and Arginine Methyltransferase in Kidney Diseases

Frontiers in Pharmacology, 2022
Methylation can occur in both histones and non-histones. Key lysine and arginine methyltransferases under investigation for renal disease treatment include enhancer of zeste homolog 2 (EZH2), G9a, disruptor of telomeric silencing 1-like protein (DOT1L ...
Xun Zhou, Hui Chen, Jinqing Li, Yingfeng Shi, Shougang Zhuang, Shougang Zhuang, Na Liu   +6 more
doaj   +1 more source

MTHFD1 controls DNA methylation in Arabidopsis. [PDF]

, 2016
DNA methylation is an epigenetic mechanism that has important functions in transcriptional silencing and is associated with repressive histone methylation (H3K9me).
Bischof, Sylvain, Cokus, Shawn J, Díaz de la Garza, Rocío I, Feng, Suhua, Garcia-Salinas, Carolina, Groth, Martin, Hale, Christopher J, Hell, Ruediger, Jacobsen, Steven E, John, Amala, Long, Jeff A, Moissiard, Guillaume, Ramos-Parra, Perla A, Smith, Danielle C, Wang, Haifeng, Wirtz, Markus, Zhai, Jixian   +16 more
core   +2 more sources

A small molecule inhibitor of leucine carboxyl methyltransferase-1 inhibits cancer cell survival

Frontiers in Drug Discovery
Reversible phosphorylation is the basis for signal transduction in eukaryotic cells, and this is tightly controlled by the complex interplay of kinases and phosphatases.
O. A. Arosarena, O. A. Arosarena, O. A. Arosarena, A. S. Saribas, E. P. Papadopoulos   +4 more
doaj   +1 more source

Bta-miR-10b secreted by bovine embryos negatively impacts preimplantation embryo quality [PDF]

, 2019
In a previous study, we found miR-10b to be more abundant in a conditioned culture medium of degenerate embryos compared to that of blastocysts. Here, we show that miR-10b mimics added to the culture medium can be taken up by embryos. This uptake results
Deforce, Dieter, Heindryckx, Björn, Lin, Xiaoyuan, Pavani, Krishna, Peelman, Luc, Smits, Katrien, Van Soom, Ann   +6 more
core   +1 more source

Histone 3 Methyltransferases Alter Melanoma Initiation and Progression Through Discrete Mechanisms

Frontiers in Cell and Developmental Biology, 2022
Perturbations to the epigenome are known drivers of tumorigenesis. In melanoma, alterations in histone methyltransferases that catalyze methylation at histone 3 lysine 9 and histone 3 lysine 27—two sites of critical post-translational modification—have ...
Sara E. DiNapoli, Sara E. DiNapoli, Raúl Martinez-McFaline, Raúl Martinez-McFaline, Hao Shen, Hao Shen, Ashley S. Doane, Alexendar R. Perez, Akanksha Verma, Amanda Simon, Isabel Nelson, Isabel Nelson, Courtney A. Balgobin, Courtney A. Balgobin, Caitlin T. Bourque, Caitlin T. Bourque, Jun Yao, Jun Yao, Renuka Raman, Renuka Raman, Wendy Béguelin, Wendy Béguelin, Jonathan H. Zippin, Olivier Elemento, Ari M. Melnick, Ari M. Melnick, Yariv Houvras, Yariv Houvras, Yariv Houvras   +28 more
doaj   +1 more source

Genome wide comparative analysis of the effects of PRMT5 and PRMT4/CARM1 arginine methyltransferases on the Arabidopsis thaliana transcriptome [PDF]

, 2015
BACKGROUND: Methylation at arginine residues (R) is an important post-translational modification that regulates a myriad of essential cellular processes in eukaryotes, such as transcriptional regulation, RNA processing, signal transduction and DNA repair.
Hernando, Carlos Esteban, Mancini, Estefania, Sanchez, Sabrina Elena, Yanovsky, Marcelo Javier   +3 more
core   +1 more source

Characterisation of the Broadly-Specific O-Methyl-transferase JerF from the Late Stages of Jerangolid Biosynthesis

Molecules, 2016
We describe the characterisation of the O-methyltransferase JerF from the late stages of jerangolid biosynthesis. JerF is the first known example of an enzyme that catalyses the formation of a non-aromatic, cyclic methylenolether.
Steffen Friedrich, Franziska Hemmerling, Frederick Lindner, Anna Warnke, Johannes Wunderlich, Gesche Berkhan, Frank Hahn   +6 more
doaj   +1 more source

H3K36 Di-Methylation Marks, Mediated by Ash1 in Complex with Caf1-55 and MRG15, Are Required during Drosophila Heart Development

Journal of Cardiovascular Development and Disease, 2023
Methyltransferases regulate transcriptome dynamics during development and aging, as well as in disease. Various methyltransferases have been linked to heart disease, through disrupted expression and activity, and genetic variants associated with ...
Jun-yi Zhu, Chen Liu, Xiaohu Huang, Joyce van de Leemput, Hangnoh Lee, Zhe Han   +5 more
doaj   +1 more source

Heterologous and High Production of Ergothioneine in Bacillus licheniformis by Using Genes from Anaerobic Bacteria

Metabolites
Purpose: This study aimed to utilize genetically engineered Bacillus licheniformis for the production of ergothioneine (EGT). Given the value of EGT and the application of Bacillus licheniformis in enzyme preparation production, we cloned the key enzymes
Zhe Liu, Fengxu Xiao, Yupeng Zhang, Jiawei Lu, Youran Li, Guiyang Shi   +5 more
doaj   +1 more source

Environmental Enrichment Reverses Histone Methylation Changes in the Aged Hippocampus and Restores Age-Related Memory Deficits

Biology, 2015
A decline in long-term memory (LTM) formation is a common feature of the normal aging process, which corresponds with abnormal expression of memory-related genes in the aged hippocampus. Epigenetic modulation of chromatin structure is required for proper
Sarah J. Morse, Anderson A. Butler, Robin L. Davis, Ian J. Soller, Farah D. Lubin   +4 more
doaj   +1 more source