Results 1 to 10 of about 4,112 (112)

Evaluation of Oxidative Stress and Antioxidant Effects of Methylxanthines in Adult Zebrafish Exposed to Zinc Oxide Nanoparticles (ZnO-NPs) [PDF]

Medicina
Background and Objectives: Oxidative stress plays a central role in numerous pathological and toxicological processes, and in vivo investigations are essential for understanding integrated systemic responses.
Cristian Dan Pavel, Carmen Lidia Chiţescu, Oana-Maria Dragostin, Lorena Dediu, Iuliana Aprodu, Ancuţa Dinu Iacob, Rodica Vatcu, Alexandra-Simona Zamfir, Carmen Lăcrămioara Zamfir   +8 more
doaj   +2 more sources

Clinical and biological impact of caffeine therapy in premature infants with apnea of prematurity: a prospective observational study [PDF]

Frontiers in Medicine
BackgroundMethylxanthines are the first-line medication in apnea of prematurity. However, serum concentrations exhibit marked variability due to immature hepatic metabolism and drug–drug interactions.ObjectivesThis study aimed to evaluate premature ...
Adela-Valeria Neamțu, Ovidiu Mircea Zlatian, Ovidiu Mircea Zlatian, Andrei Theodor Bălășoiu, Andrei Theodor Bălășoiu, Costel-Valentin Manda, Carla-Maria Bărbulescu-Mateescu, Ana-Maria Pătrașcu, Ana-Maria Pătrașcu, Ramona Cioboată, Ramona Cioboată, Liliana Stanca, Olivia Garofița Mateescu, Olivia Garofița Mateescu, Ștefan Pătrașcu, Ștefan Pătrașcu, Antonia Radu, Simona-Daniela Neamțu, Simona-Daniela Neamțu   +18 more
doaj   +2 more sources

Airway microbial and metabolic features associated with ICS therapy in COPD [PDF]

Frontiers in Pharmacology
BackgroundInhaled corticosteroids (ICS) are a cornerstone of therapy for selected phenotypes of chronic obstructive pulmonary disease (COPD), yet the underlying mechanisms remain incompletely understood.
Lijun Chen, Mei Yang, Qixin Wang, Yan Tang, Hongxia Yu, Xianhui Luo, Xiaochao Du, Haizong Hu   +7 more
doaj   +2 more sources

Methylxanthine use in infants with hypoxic-ischemic encephalopathy: a retrospective cohort study [PDF]

Scientific Reports
Therapeutic hypothermia is the standard treatment for hypoxic-ischemic encephalopathy (HIE), but despite its widespread use, the rates of mortality and neurodevelopmental impairment for moderate to severe HIE remain around 30%.
Madeleine E. Laughon, Jacob K. Johnson, Rachel G. Greenberg, Reese H. Clark, Wesley M. Jackson   +4 more
doaj   +2 more sources

Graphene Oxide: A Smart (Starting) Material for Natural Methylxanthines Adsorption and Detection

Molecules, 2019
Natural methylxanthines, caffeine, theophylline and theobromine, are widespread biologically active alkaloids in human nutrition, found mainly in beverages (coffee, tea, cocoa, energy drinks, etc.). Their detection is thus of extreme importance, and many
Giuseppe Zollo, Isabella Chiarotto, Marco Rossi   +2 more
exaly   +3 more sources

Mixture Design and Doehlert Matrix for Optimization of Energized Dispersive Guided Extraction (EDGE) of Theobromine and Caffeine from Cocoa Bean Shells [PDF]

Foods
This work describes the development of a method for the extraction of methylxanthines from cocoa bean shell (CBS) by employing the novel Energized Dispersive Guided Extraction (EDGE) system.
Luciana Lordêlo Nascimento, Paulo Natan Alves dos Santos, Honnara Santos Granja, Larissa da Silveira Ferreira, João Victor Ferreira Lima, Bruna Louise de Moura Pita, Allan dos Santos Polidoro, Lisiane dos Santos Freitas, Elina Bastos Caramão, Fabio de Souza Dias, Alini Tinoco Fricks   +10 more
doaj   +2 more sources

Methylxanthine and Flavonoid Contents from Guarana Seeds (Paullinia cupana): Comparison of Different Drying Techniques and Effects of UV Radiation [PDF]

International Journal of Food Science
Guarana seeds are typically processed using one of three drying methods: traditional sun exposure, greenhouse drying, or the alguidar oven technique.
André Luiz Sampaio da Silva Junior, Madson Moreira Nascimento, Herick Macedo Santos, Ivon Pinheiro Lôbo, Rosilene Aparecida de Oliveira, Raildo Mota de Jesus   +5 more
doaj   +2 more sources

Miscibility and Solubility of Caffeine and Theophylline in Hydroxypropyl Methylcellulose

Pharmaceutics, 2021
As amorphization may improve the solubility and bioavailability of a drug substance, the aim of this work was to assess to what extent the crystallinity of caffeine (CAF) and theophylline (TF) can be reduced by homogenization with a polymeric excipient ...
Edyta Leyk, Marek Wesolowski
doaj   +1 more source

Bioactive compounds and leaf anatomy of yerba mate morphotypes [PDF]

Pesquisa Agropecuária Brasileira, 2022
The objective of this work was to evaluate the bioactive compounds and foliar anatomy of yerba mate (Ilex paraguariensis) morphotypes. The antioxidant capacity, total phenolic compounds, methylxanthines, and caffeoylquinic acids were determined from the ...
Manoela Mendes Duarte, Mônica Moreno Gabira, Jéssica de Cássia Tomasi, Erika Amano, Antonio Carlos Nogueira, Ivar Wendling   +5 more
doaj   +1 more source

Methylxanthines Modulate Circadian Period Length Independently of the Action of Phosphodiesterase

Microbiology Spectrum, 2023
In Neurospora crassa, caffeine and other methylxanthines are known to inhibit phosphodiesterase (PDE) activity, leading to augmented cAMP levels. In this organism, it has also been shown that the addition of these drugs significantly lengthens the ...
Consuelo Olivares-Yañez, María P. Alessandri, Loreto Salas, Luis F. Larrondo   +3 more
doaj   +1 more source