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From Isoprene Units to Polyprenols and Dolichols: 70 Years of Polyisoprenoid Biosynthesis Research. [PDF]
Cell Biochem BiophysBechler Z, Surmacz L.
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Microbial production of mevalonate
Journal of Biotechnology, 2023Mevalonate, an important intermediate product of the mevalonate pathway, has a broad spectrum of applications. With the rapid growth of metabolic engineering and synthetic biology, mevalonate biosynthesis by microorganisms is feasible and holds great promise in the future.
Li-Juan Wang
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Basic and Clinical Observations of Mevalonate Depletion on the Mevalonate Signaling Pathway
Current Molecular Pharmacology, 2017Inhibition of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase by pharmaceuticals, commonly referred to as statins, has proven to be an effective and efficient way in reducing cholesterol levels in patients. As a result of this intervention, mevalonate production, formed during cholesterol synthesis, is inhibited.
Darren Freed
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Both the mevalonate and the non-mevalonate pathways are involved in ginsenoside biosynthesis
Plant Cell Reports, 2013When one of them was inhibited, the two pathways could compensate with each other to guarantee normal growth. Moreover, the sterol biosynthesis inhibitor miconazole could enhance ginsenoside level.Ginsenosides, a kind of triterpenoid saponins derived from isopentenyl pyrophosphate (IPP), represent the main pharmacologically active constituents of ...
Shoujing Zhao
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Targeting the Mevalonate Pathway in Cancer [PDF]
Trends in Cancer, 2021 The mevalonate synthesis inhibitors, statins, are mainstay therapeutics for cholesterol management and cardiovascular health. Thirty years of research has uncovered supportive roles for the mevalonate pathway in numerous cellular processes that support ...
David Fruman, Dennis Juarez
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Metabolic Induction of Trained Immunity through the Mevalonate Pathway
Cell, 2018 Innate immune cells can develop long-term memory after stimulation by microbial products during infections or vaccinations. Here, we report that metabolic signals can induce trained immunity. Pharmacological and genetic experiments reveal that activation
Leo Joosten, Julia van Tuijl
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Mevalonate Pathway Blockade, Mitochondrial Dysfunction and Autophagy: A Possible Link [PDF]
International Journal of Molecular Sciences, 2015 The mevalonate pathway, crucial for cholesterol synthesis, plays a key role in multiple cellular processes. Deregulation of this pathway is also correlated with diminished protein prenylation, an important post-translational modification necessary to ...
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Mevalonate metabolism in cancer
Cancer Letters, 2015Cancer cells are characterized by sustained proliferative signaling, insensitivity to growth suppressors and resistance to apoptosis as well as by replicative immortality, the capacity to induce angiogenesis and to perform invasive growth. Additional hallmarks of cancer cells include the reprogramming of energy metabolism as well as the ability to ...
Georg, Gruenbacher, Martin, Thurnher
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Analytical Biochemistry, 1970
Abstract A suitable assay has been developed for accurate measurements of mevalonate kinase in a crude enzyme preparation. The assay is particularly useful where comparative, tissue-specific, or developmental studies are to be made on mevalonate kinase.
T R, Green, D J, Baisted
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Abstract A suitable assay has been developed for accurate measurements of mevalonate kinase in a crude enzyme preparation. The assay is particularly useful where comparative, tissue-specific, or developmental studies are to be made on mevalonate kinase.
T R, Green, D J, Baisted
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Regulation of the mevalonate pathway
Nature, 1990The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products ...
J L, Goldstein, M S, Brown
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