Results 181 to 190 of about 24,117 (219)

Genes for mevalonate biosynthesis in Phycomyces

Molecular Genetics and Genomics, 2002
Terpenoids or isoprenoids constitute a vast family of organic compounds that includes sterols and carotenoids. The terpenoids in many organisms share early steps in their biosynthesis, including the synthesis of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) and its conversion to mevalonate.
J, Ruiz-Albert, E, Cerdá-Olmedo, L M, Corrochano   +2 more
openaire   +2 more sources

Metabolic Engineering of the Mevalonate and Non-Mevalonate Pathways in Tomato

2003
In higher plants isoprenoids have many essential roles e.g. in membrane structure (phytosterols), redox chemistry (plastoquinone) and as antioxidants (carotenoids). Despite their functional and chemical diversity all isoprenoids are biosynthetically related from a common precursor, isopentenyl pyrophosphate (IPP).
E. M. Enfissi, P. D. Fraser, L. M. Lois, A. Boronat, W. Schuch, P. M. Bramley   +5 more
openaire   +1 more source

Mevalonate synthesis in the mitochondria of yeast

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1973
Abstract 1. 1. Subcellular fractions were obtained bydifferential centrifugation of the homogenate of spheroplasts prepared from aerobically cultured Saccharomyces cerevisiae. The localization of the enzymes involved in the early stage of ergosterol synthesis was investigated. 2. 2.
I, Shimizu, J, Nagai, H, Hatanaka, H, Katsuki   +3 more
openaire   +2 more sources

Multienzyme mevalonate pathway bioreactor

Biotechnology and Bioengineering, 2004
AbstractThe five‐carbon metabolic intermediate isopentenyl diphosphate constitutes the basic building block for the biosynthesis of all isoprenoids in all forms of life. Two distinct pathways lead from amphibolic intermediates to isopentenyl diphosphate.
Autumn, Sutherlin, Victor W, Rodwell
openaire   +2 more sources

Mevalonic aciduria

Journal of Inherited Metabolic Disease, 1991
V, Kozich, K M, Gibson, J, Zeman, J, Nĕmecek, G F, Hoffman, F, Pehal, J, Hyánek, A, Grosmanová, P, Verner   +8 more
openaire   +2 more sources

Mevalonic Aciduria

2023
Amirhossein Habibzadeh, Shaghayegh Khanmohammadi   +1 more
openaire   +1 more source

Targeting the Mevalonate Pathway in Cancer

Trends in Cancer, 2021
David Fruman, Dennis Juarez
exaly  

Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis

Cancer Cell, 2023
Rugang Zhang, Hao Nie
exaly  

MEVALONIC ACID MEVALONIC LACTONE

1976
Darshan Ranganathan, Subramania Ranganathan   +1 more
openaire   +1 more source

p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression

Cell, 2019
Allison Mayle, Timour Baslan, Edward Kastenhuber   +2 more
exaly