Results 181 to 190 of about 43,962 (233)
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Microbial production of mevalonate
Journal of Biotechnology, 2023Mevalonate, an important intermediate product of the mevalonate pathway, has a broad spectrum of applications. With the rapid growth of metabolic engineering and synthetic biology, mevalonate biosynthesis by microorganisms is feasible and holds great promise in the future.
Cong-Han, Wang +3 more
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Mevalonate metabolism in cancer
Cancer Letters, 2015Cancer cells are characterized by sustained proliferative signaling, insensitivity to growth suppressors and resistance to apoptosis as well as by replicative immortality, the capacity to induce angiogenesis and to perform invasive growth. Additional hallmarks of cancer cells include the reprogramming of energy metabolism as well as the ability to ...
Georg, Gruenbacher, Martin, Thurnher
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Mevalonate Biosynthesis in Plants
Critical Reviews in Biochemistry and Molecular Biology, 1999(1999). Mevalonate Biosynthesis in Plants. Critical Reviews in Biochemistry and Molecular Biology: Vol. 34, No. 2, pp. 107-122.
T J, Bach +4 more
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Analytical Biochemistry, 1970
Abstract A suitable assay has been developed for accurate measurements of mevalonate kinase in a crude enzyme preparation. The assay is particularly useful where comparative, tissue-specific, or developmental studies are to be made on mevalonate kinase.
T R, Green, D J, Baisted
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Abstract A suitable assay has been developed for accurate measurements of mevalonate kinase in a crude enzyme preparation. The assay is particularly useful where comparative, tissue-specific, or developmental studies are to be made on mevalonate kinase.
T R, Green, D J, Baisted
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Multienzyme mevalonate pathway bioreactor
Biotechnology and Bioengineering, 2004AbstractThe five‐carbon metabolic intermediate isopentenyl diphosphate constitutes the basic building block for the biosynthesis of all isoprenoids in all forms of life. Two distinct pathways lead from amphibolic intermediates to isopentenyl diphosphate.
Autumn, Sutherlin, Victor W, Rodwell
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Mevalonate kinase deficiency nomenclature
Rheumatology International, 2013In the letter of Celsi et al. [1], the authors suggest dropping the names of hyper-IgD syndrome (HIDS) and mevalonate kinase deficiency (MKD) for this hereditary syndrome. They base their conclusion upon the fact that there is no correlation between serum IgD concentration and disease severity, that not all HIDS patients show elevated IgD, and that ...
Stoffels, M. +2 more
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Bifunctional Inhibitors of Mevalonate Kinase and Mevalonate 5-Diphosphate Decarboxylase
Organic Letters, 2006[structure: see text] A bifunctional inhibitor of mevalonate kinase and mevalonate 5-diphosphate decarboxylase was synthesized. Both enzymes are in the cholesterol biosynthetic pathway and play an important role in regulating cholesterol biosynthesis.
Yongge, Qiu, Ding, Li
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Regulation of the mevalonate pathway
Nature, 1990The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products ...
Joseph L Goldstein, Michael S Brown
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Mevalonate kinase deficiency in a dizygotic twin with mild mevalonic aciduria
Journal of Inherited Metabolic Disease, 1997Mevalonic aciduria, the result of mevalonate kinase (MKase) deficiency (McKusick 251170), is a rare abnormality of cholesterol and nonsterol isoprene biosynthesis identified in approximately 14 patients. The phenotype includes developmental delays, failure to thrive, hypotonia, ataxia, organomegaly, dysmorphia, cataracts, lymphadenopathy, myopathy and ...
K M, Gibson +3 more
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Severe phenotypic spectrum of mevalonate kinase deficiency with minimal mevalonic aciduria
Molecular Genetics and Metabolism, 2012Mevalonate kinase deficiency is a rare autosomal recessively inherited organic aciduria with a complex multi-systemic phenotype. We describe two deceased patients with clinically severe mevalonate kinase (MK) deficiency confirmed by MK mutation analysis.
Chitra, Prasad +2 more
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