Results 191 to 200 of about 43,962 (233)
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Basic and Clinical Observations of Mevalonate Depletion on the Mevalonate Signaling Pathway
Current Molecular Pharmacology, 2017Inhibition of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase by pharmaceuticals, commonly referred to as statins, has proven to be an effective and efficient way in reducing cholesterol levels in patients. As a result of this intervention, mevalonate production, formed during cholesterol synthesis, is inhibited.
Alison L, Muller, Darren H, Freed
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2016
Mevalonate kinase deficiency (MKD) is an autosomal recessive inborn error of isoprenoid biosynthesis, a pathway yielding sterols and nonsterol isoprenoids.In patients, the enzyme activity of mevalonate kinase is severely reduced due to mutations in the encoding gene, MVK.
Frenkel, Joost, Waterham, Hans R.
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Mevalonate kinase deficiency (MKD) is an autosomal recessive inborn error of isoprenoid biosynthesis, a pathway yielding sterols and nonsterol isoprenoids.In patients, the enzyme activity of mevalonate kinase is severely reduced due to mutations in the encoding gene, MVK.
Frenkel, Joost, Waterham, Hans R.
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Mevalonate Pathway and Human Cancers
Current Molecular Pharmacology, 2017Mevalonate (MVA) is synthesized from 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) by HMG-CoA reductase (HMG-CoAR). MVA is further metabolized to farnesyl pyrophosphate (FPP), a precursor of cholesterol and sterols. FPP is also converted to geranylgeranyl pyrophosphate, and these lipids are used for post-translational modification of proteins that ...
Seyedeh Zahra, Bathaie +3 more
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Mevalonate Metabolism: Role of Kidneys
Science, 1976More than one-half of the amount of mevalonate that is metabolized by pathways not leading to sterols is accounted for by the action of the kidneys. Conversion of mevalonate in vivo to squalene and sterols in the kidneys is confined almost entirely to the proximal and distal convoluted tubules in the cortex.
J, Edmond, A M, Fogelman, G, Popják
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2019
Mevalonate kinase deficiency (MKD) is a rare autoinflammatory disease caused by loss of function mutations in both alleles of MVK, the gene encoding the enzyme mevalonate kinase. Deficiency of this enzyme results in impaired isoprenoid biosynthesis. The inflammatory attacks in MKD are characterized by fever, lymphadenopathy, gastrointestinal symptoms ...
Joost Frenkel, Anna Simon
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Mevalonate kinase deficiency (MKD) is a rare autoinflammatory disease caused by loss of function mutations in both alleles of MVK, the gene encoding the enzyme mevalonate kinase. Deficiency of this enzyme results in impaired isoprenoid biosynthesis. The inflammatory attacks in MKD are characterized by fever, lymphadenopathy, gastrointestinal symptoms ...
Joost Frenkel, Anna Simon
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Mevalonate metabolism in pregnant rats
Metabolism, 1980Abstract Mevalonate is converted to cholesterol by the sterol pathway or can be oxidized to CO2 by the shunt pathway; the kidneys are the chief site of mevalonate metabolism in both pathways. Recently, a major sex difference in circulating mevalonate metabolism has been observed in rats and in humans; in rats, females oxidized mevalonate to CO2 at ...
K R, Feingold +3 more
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Mevalonate biosynthesis in rat liver
Lipids, 1970AbstractMevalonate synthesis in rat liver can occur not only from HMG‐CoA utilizing particle‐bound HMG‐CoA reductase, but from malonyl‐CoA utilizing soluble enzymes. From a strictly quantitative standpoint, synthesis from malonyl‐CoA appears to be of minor importance.
G M, Fimognari, V W, Rodwell
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Mevalonate Kinase Deficiency: Disclosing the Role of Mevalonate Pathway Modulation in Inflammation
Current Pharmaceutical Design, 2012Inflammation is a highly regulated process involved both in the response to pathogens as well as in tissue homeostasis. In recent years, a complex network of proteins in charge of inflammation control has been revealed by the study of hereditary periodic fever syndromes.
A. Marcuzzi +5 more
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