Results 11 to 20 of about 534,915 (376)
Definitions, 2020 A family of genes expressed mainly by antigen presenting cells that encode major histocompatibility complex proteins and are involved in the presentation of fragments from phagocytized extracellular proteins to cytotoxic lymphocytes.
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Present Yourself! By MHC Class I and MHC Class II Molecules. [PDF]
Trends in Immunology, 2016 Since the discovery of MHC molecules, it has taken 40 years to arrive at a coherent picture of how MHC class I and MHC class II molecules really work. This is a story of the proteases and MHC-like chaperones that support the MHC class I and II molecules in presenting peptides to the immune system.
K. Rock, E. Reits, J. Neefjes
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Cell Reports, 2023 Summary: Major histocompatibility complex (MHC) class II-reactive CD8+ T cells are found in humans and animals, but little is known about their identity, development, and function.
Xiaojuan Zhou +17 more
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Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome
Frontiers in Immunology, 2022 In the last few years, advancement in the analysis of the MHC class II (MHC-II) ligandome in several mouse and human haplotypes has increased our understanding of the molecular components that regulate the range and selection of the MHC-II presented ...
Laura Santambrogio +2 more
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The Journal of Immunology, 2012 Abstract MHC class II tetramers have emerged as an important tool for characterization of the specificity and phenotype of CD4 T cell immune responses, useful in a large variety of disease and vaccine studies. Issues of specific T cell frequency, biodistribution, and avidity, coupled with the large genetic diversity of potential class II
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MHC class II transport at a glance [PDF]
Journal of Cell Science, 2009 The cellular immune system functions in large part to recognize and destroy foreign pathogens. This process is aided by antigen-presenting cells (APCs), which internalize, degrade and subsequently express small antigenic fragments from foreign bodies on their cell surfaces.
Adam C, Berger, Paul A, Roche
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BMC Evolutionary Biology, 2019 Background Genes of the Major Histocompatibility Complex (MHC) are essential for adaptive immune response in vertebrates, as they encode receptors that recognize peptides derived from the processing of intracellular (MHC class I) and extracellular (MHC ...
Piotr Minias +2 more
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MHC class II expression in human basophils: induction and lack of functional significance. [PDF]
PLoS ONE, 2013 The antigen-presenting abilities of basophils and their role in initiating a Th2 phenotype is a topic of current controversy. We aimed to determine whether human basophils can be induced to express MHC Class II and act as antigen presenting cells for T ...
Astrid L Voskamp +4 more
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Melanosomal targeting sequences from gp100 are essential for MHC class II-restricted endogenous epitope presentation and mobilization to endosomal compartments [PDF]
, 2006 CD4+ T lymphocytes play an important role in CD8+ T cell-mediated responses against tumors. Considering that about 20% of melanomas express major histocompatibility complex (MHC) class II, it is plausible that concomitant antigenic presentation by MHC ...
Lapointe, Réjean, Lepage, Stéphanie
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