Results 21 to 30 of about 534,915 (376)

Allelic diversity and patterns of selection at the major histocompatibility complex class I and II loci in a threatened shorebird, the Snowy Plover (Charadrius nivosus)

BMC Evolutionary Biology, 2020
Background Understanding the structure and variability of adaptive loci such as the major histocompatibility complex (MHC) genes is a primary research goal for evolutionary and conservation genetics.
Medardo Cruz-López, Guillermo Fernández, Helen Hipperson, Eduardo Palacios, John Cavitt, Daniel Galindo-Espinosa, Salvador Gómez del Angel, Raya Pruner, Oscar Gonzalez, Terry Burke, Clemens Küpper   +10 more
doaj   +1 more source

Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation

Frontiers in Immunology, 2017
Antigen presentation by major histocompatibility complex (MHC) proteins is essential for adaptive immunity. Prior to presentation, peptides need to be generated from proteins that are either produced by the cell’s own translational machinery or that are ...
M. Wieczorek, Esam T. Abualrous, J. Sticht, Miguel Álvaro-Benito, Sebastian Stolzenberg, F. Noé, C. Freund   +6 more
semanticscholar   +1 more source

Common Genetic Variant Association with Altered HLA Expression, Synergy with Pyrethroid Exposure, and Risk for Parkinson's Disease: An Observational and Case-Control Study. [PDF]

, 2015
Background/objectivesThe common non-coding single nucleotide polymorphism (SNP) rs3129882 in HLA-DRA is associated with risk for idiopathic Parkinson's disease (PD).
Boss, JM, Bronstein, J, Chang, J, Chung, J, Cook, DA, Factor, SA, Kannarkat, GT, Lee, J-K, Paul, KC, Ritz, B, Sandy, E, Tansey, MG   +11 more
core   +2 more sources

MHC Class II and Non-MHC Class II Genes Differentially Influence Humoral Immunity to Bacillus anthracis Lethal Factor and Protective Antigen

Toxins, 2012
Anthrax Lethal Toxin consists of Protective Antigen (PA) and Lethal Factor (LF), and current vaccination strategies focus on eliciting antibodies to PA. In human vaccination, the response to PA can vary greatly, and the response is often directed toward ...
Judith A. James, A. Darise Farris, Melissa L. Nguyen, Philip M. Cox, Sherry R. Crowe, Eric K. Dumas, Sridevi Kurella, Jonathan J. Hunt, Lori Garman   +8 more
doaj   +1 more source

Towards universal structure-based prediction of class II MHC epitopes for diverse allotypes. [PDF]

PLoS ONE, 2010
The binding of peptide fragments of antigens to class II MHC proteins is a crucial step in initiating a helper T cell immune response. The discovery of these peptide epitopes is important for understanding the normal immune response and its misregulation
Andrew J Bordner
doaj   +1 more source

Multiple expressed MHC class II loci in salmonids; details of one non-classical region in Atlantic salmon (Salmo salar)

BMC Genomics, 2008
Background In teleosts, the Major Histocompatibility Complex (MHC) class I and class II molecules reside on different linkage groups as opposed to tetrapods and shark, where the class I and class II genes reside in one genomic region. Several teleost MHC
Bakke Hege G, Lukacs Morten F, Harstad Håvard, Grimholt Unni   +3 more
doaj   +1 more source

Atlantic cod (Gadus morhua) MHC I localizes to endolysosomal compartments independently of cytosolic sorting signals

Frontiers in Cell and Developmental Biology, 2023
Major histocompatibility complex (MHC) class I and II are crucial for the adaptive immune system because they are involved in peptide presentation to T cells.
Synne Arstad Bjørnestad, Monica Hongrø Solbakken, Kjetill S. Jakobsen, Sissel Jentoft, Oddmund Bakke, Cinzia Progida   +5 more
doaj   +1 more source

Epithelial MHC Class II Expression and Its Role in Antigen Presentation in the Gastrointestinal and Respiratory Tracts

Frontiers in Immunology, 2018
As the primary barrier between an organism and its environment, epithelial cells are well-positioned to regulate tolerance while preserving immunity against pathogens.
J. Wosen, Dhriti Mukhopadhyay, C. Macaubas, E. Mellins   +3 more
semanticscholar   +1 more source

Diminished Intracellular Invariant Chain Expression Following Vaccinia Virus Infection [PDF]

, 2009
Vaccinia virus (VV) has been used as a vaccine to eradicate smallpox and as a vaccine for HIV and tumors. However, the immunoevasive properties of VV, have raised safety concerns.
Blum, Janice S., Wang, Nan, Weber, Ekkehard   +2 more
core   +1 more source

Xenografts of MHC-Deficient Mouse Embryonic Mesencephalon Improve Behavioral Recovery in Hemiparkinsonian Rats

Cell Transplantation, 2002
The limited availability of human embryonic tissue for dopamine cell transplants in Parkinson's patients has led to an increased interest in using xenogeneic donor tissue.
Lone M. Veng, Kimberly B. Bjugstad, Curt R. Freed, Philippa Marrack, Edward D. Clarkson, K. Patricia Bell, Cindy Hutt, W. Michael Zawada Ph.D.   +7 more
doaj   +1 more source