Results 1 to 10 of about 1,936 (157)

Development of KSHV vaccine platforms and chimeric MHV68-K-K8.1 glycoprotein for evaluating the in vivo immunogenicity and efficacy of KSHV vaccine candidates. [PDF]

mBio
ABSTRACT Kaposi’s sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 is an etiological agent of Kaposi’s Sarcoma, multicentric Castleman’s disease, and primary effusion lymphoma. Considering the high seroprevalence reaching up to 80% in sub-Saharan Africa, an effective vaccine is crucial for ...
Yang W-S, Kim D, Kang S, Lai C-J, Cha I, Chang P-C, Jung JU.   +6 more
europepmc   +5 more sources

A replication-deficient gammaherpesvirus vaccine protects mice from lytic disease and reduces latency establishment. [PDF]

NPJ Vaccines
Gammaherpesviruses are oncogenic viruses that establish lifelong infections and are significant causes of morbidity and mortality. Vaccine strategies to limit gammaherpesvirus infection and disease are in development, but there are no FDA-approved ...
Bland WA, Mitra D, Owens S, McEvoy K, Hogan CH, Boccuzzi L, Kirillov V, Meyer TJ, Khairallah C, Sheridan BS, Forrest JC, Krug LT.   +11 more
europepmc   +4 more sources

Optimized Detection of Acute MHV68 Infection With a Reporter System Identifies Large Peritoneal Macrophages as a Dominant Target of Primary Infection [PDF]

Frontiers in Microbiology, 2020
Investigating the dynamics of virus-host interactions in vivo remains an important challenge, often limited by the ability to directly identify virally infected cells. Here, we utilize a beta-lactamase activated fluorescent substrate to identify primary targets of murine gammaherpesvirus 68 ...
Julianne B. Riggs, Eva M. Medina, Loni J. Perrenoud, Diana L. Bonilla, Eric T. Clambey, Linda F. van Dyk, Leslie J. Berg   +6 more
openaire   +4 more sources

Guinea pig herpes like virus is a gamma herpesvirus. [PDF]

Virus Genes
Guinea Pig Herpes-Like Virus (GPHLV) is a virus isolated from leukemic guinea pigs with herpes virus-like morphology described by Hsiung and Kaplow in 1969.
Stanfield BA, Ruiz E, Chouljenko VN, Kousoulas KG.   +3 more
europepmc   +3 more sources

MHV68 Latency Modulates the Host Immune Response to Influenza A Virus [PDF]

Inflammation, 2013
Murine gammaherpesvirus 68 (MHV68) is a natural rodent pathogen that has been used as a model to study the pathogenesis of human gammaherpesviruses. Like other herpesviruses, MHV68 causes acute infection and establishes life-long latency in the host.
Saito, Fumitake, Ito, Toshihiro, Connett, Judith M., Schaller, Matthew A., Carson, William F., Hogaboam, Cory M., Rochford, Rosemary, Kunkel, Steven L.   +7 more
openaire   +2 more sources

CD95-CD95L interaction mediates the growth control of MHV68 immortalized B cells by cytotoxic T cells [PDF]

Virologica Sinica, 2017
In conclusion, our current data demonstrate that MHV68-immortalized SL-1 cells can be recognized and controlled by specific cytotoxic T cells through CD95/CD95L-mediated apoptosis. This is in agreement with that CD4 T cells control the growth of EBV-infected cells through CD95/CD95L-mediated apoptosis, which suggests that the growth control of ...
Sihan Dong, Lingbing Tan, Guifang Chen, Xiaozhen Liang   +3 more
openaire   +2 more sources

Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the Avy obesity-associated gene. [PDF]

, 2019
There has been considerable debate as to whether obesity can act as an accelerator of type 1 diabetes (T1D). We assessed this possibility using transgenic mice (MIP-TF mice) whose ß-cells express enhanced green fluorescent protein (EGFP). Infecting these
Atkinson, Mark A, Dang, Hoa, Kaufman, Daniel L, Sun, Ren, Tian, Jide, Wu, Ting-Ting, Yong, Jing   +6 more
core   +2 more sources

MHV68 complement regulatory protein facilitates MHV68 replication in primary macrophages in a complement independent manner

Virology, 2010
Murine gammaherpesvirus-68 (MHV68) is genetically related to human Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus and provides a tractable model to study gammaherpesvirus-host interactions in vivo and in vitro. The MHV68-encoded v-RCA product inhibits murine complement activation and shares sequence homology with other virus and host ...
Tarakanova, Vera L., Molleston, Jerome M., Goodwin, Megan, Virgin, Herbert W.   +3 more
openaire   +2 more sources

Identification of Alternative Transcripts Encoding the Essential Murine Gammaherpesvirus Lytic Transactivator RTA [PDF]

, 2014
The essential immediate early transcriptional activator RTA, encoded by gene 50, is conserved among all characterized gammaherpesviruses. Analyses of a recombinant murine gammaherpesvirus 68 (MHV68) lacking both of the known gene 50 promoters (G50DblKo ...
Gray, Kathleen S, Johnson, L. Steven, Paden, Clinton R, Speck, Samuel H, Virgin, Herbert W, Wakeman, Brian S   +5 more
core   +2 more sources

A Human Torque Teno Virus Encodes a MicroRNA That Inhibits Interferon Signaling [PDF]

, 2013
Rodney P. Kincaid, James M. Burke, Jennifer C. Cox, Christopher S. Sullivan, The University of Texas at Austin, Molecular Genetics and Microbiology, Austin, Texas, United States of AmericaEthel-Michele de Villiers, Division for the Characterization of ...
Burke, James M., Cox, Jennifer C., de Villiers, Ethel-Michele, Kincaid, Rodney P., Sullivan, Christopher S.   +4 more
core   +2 more sources