Results 91 to 100 of about 1,936 (157)

Genome-wide Transcript Structure Resolution Reveals Abundant Alternate Isoform Usage from Murine Gammaherpesvirus 68

Cell Reports, 2019
Summary: The gammaherpesviruses, including Epstein-Barr virus (EBV), Kaposi's sarcoma-associated herpesvirus (KSHV), and murine gammaherpesvirus 68 (MHV68, MuHV-4, γHV68), are etiologic agents of a wide range of lymphomas and non-hematological ...
Tina O’Grady, April Feswick, Brett A. Hoffman, Yiping Wang, Eva M. Medina, Mehmet Kara, Linda F. van Dyk, Erik K. Flemington, Scott A. Tibbetts   +8 more
doaj   +1 more source

Transnuclear TRP1-Specific CD8 T Cells with High or Low Affinity TCRs Show Equivalent Antitumor Activity [PDF]

, 2018
We have generated, via somatic cell nuclear transfer, two independent lines of transnuclear (TN) mice, using as nuclear donors CD8 T cells, sorted by tetramer staining, that recognize the endogenous melanoma antigen TRP1.
Celis, E., Cho, H.-I., Dougan, M., Dougan, S. K., Jaenisch, R., Kim, Jun, Ogata, S., Ploegh, H. L., Turner, J. A.   +8 more
core   +1 more source

TLRs Go Linear – On the Ubiquitin Edge [PDF]

, 2017
Toll-like receptors (TLRs) are crucial in protecting the host from pathogens. However, their exact role in disease remains incompletely understood.
Walczak, H, Zinngrebe, J
core  

Construction and characterization of an infectious murine gammaherpesivrus-68 bacterial artificial chromosome [PDF]

, 2011
Here we describe the cloning of a sequenced WUMS isolate of murine gammaherpesvirus-68 (MHV-68, γHV-68, also known as MuHV-4) as a bacterial artificial chromosome (BAC).
Wu, Ting Ting, Liao, Hsiang I., Tong, Leming, Leang, Ronika Sitapara, Smith, Greg, Sun, Ren   +5 more
core   +2 more sources

The murine gammaherpesvirus immediate-early Rta synergizes with IRF4, targeting expression of the viral M1 superantigen to plasma cells.

PLoS Pathogens, 2014
MHV68 is a murine gammaherpesvirus that infects laboratory mice and thus provides a tractable small animal model for characterizing critical aspects of gammaherpesvirus pathogenesis.
Brigid M O'Flaherty, Tanushree Soni, Brian S Wakeman, Samuel H Speck   +3 more
doaj   +1 more source

Evaluation of immune sensor responses to a viral small noncoding RNA. [PDF]

Front Cell Infect Microbiol
IntroductionGammaherpesviruses are widespread pathogens causing persistent infections linked to the development of numerous types of lymphomas in humans.
Kara M, Tibbetts SA.
europepmc   +2 more sources

Murine gammaherpesvirus M2 protein induction of IRF4 via the NFAT pathway leads to IL-10 expression in B cells.

PLoS Pathogens, 2014
Reactivation of the gammaherpesviruses Epstein-Barr virus (EBV), Kaposi's sarcoma-associated herpesvirus (KSHV) and murine gammaherpesvirus 68 (MHV68) from latently infected B cells has been linked to plasma cell differentiation. We have previously shown
Udaya S Rangaswamy, Samuel H Speck
doaj   +1 more source

Murine gammaherpesvirus infection is skewed toward Igλ+ B cells expressing a specific heavy chain V-segment.

PLoS Pathogens, 2020
One of the defining characteristics of the B cell receptor (BCR) is the extensive diversity in the repertoire of immunoglobulin genes that make up the BCR, resulting in broad range of specificity.
Christopher M Collins, Christopher D Scharer, Thomas J Murphy, Jeremy M Boss, Samuel H Speck   +4 more
doaj   +1 more source

Viral SERPINS—A Family of Highly Potent Immune-Modulating Therapeutic Proteins [PDF]

, 2023
Serine protease inhibitors, SERPINS, are a highly conserved family of proteins that regulate serine proteases in the central coagulation and immune pathways, representing 2–10% of circulating proteins in the blood.
Beladi, Roxana, Hamada, Mostafa, Irving, James, Lucas, Alexandra R, McFadden, Grant, Varkoly, Kyle   +5 more
core  

Multifaceted roles for STAT3 in gammaherpesvirus latency revealed through in vivo B cell knockout models. [PDF]

mBio
Cancers associated with the oncogenic gammaherpesviruses, Epstein-Barr virus and Kaposi sarcoma herpesvirus, are notable for their constitutive activation of the transcription factor signal transducer and activator of transcription 3 (STAT3).
Hogan CH, Owens SM, Reynoso GV, Liao Y, Meyer TJ, Zelazowska MA, Liu B, Li X, Grosskopf AK, Khairallah C, Kirillov V, Reich NC, Sheridan BS, McBride KM, Gewurz BE, Hickman HD, Forrest JC, Krug LT.   +17 more
europepmc   +2 more sources