Results 11 to 20 of about 1,936 (157)

The MHV68 M2 Protein Drives IL-10 Dependent B Cell Proliferation and Differentiation [PDF]

PLoS Pathogens, 2008
Murine gammaherpesvirus 68 (MHV68) establishes long-term latency in memory B cells similar to the human gammaherpesvirus Epstein Barr Virus (EBV). EBV encodes an interleukin-10 (IL-10) homolog and modulates cellular IL-10 expression; however, the role of IL-10 in the establishment and/or maintenance of chronic EBV infection remains unclear.
Andrea M Siegel, Jeremy H Herskowitz, Samuel H Speck   +2 more
openaire   +4 more sources

A role of hypoxia-inducible factor 1 alpha in Murine Gammaherpesvirus 68 (MHV68) lytic replication and reactivation from latency

PLOS Pathogens, 2019
ABSTRACTThe hypoxia inducible factor 1 alpha (HIFIα) protein and the hypoxic microenvironment are critical for infection and pathogenesis by the oncogenic gammaherpesviruses (γHV) such as Kaposi’ Sarcoma-associated Herpes Virus (KSHV) and Epstein-Barr virus (EBV).
Darlah M. López-Rodríguez, Varvara Kirillov, Laurie T. Krug, Enrique A. Mesri, Samita Andreansky   +4 more
openaire   +4 more sources

Conditional mutagenesis in vivo reveals cell type- and infection stage-specific requirements for LANA in chronic MHV68 infection [PDF]

PLOS Pathogens, 2018
Gammaherpesvirus (GHV) pathogenesis is a complex process that involves productive viral replication, dissemination to tissues that harbor lifelong latent infection, and reactivation from latency back into a productive replication cycle. Traditional loss-of-function mutagenesis approaches in mice using murine gammaherpesvirus 68 (MHV68), a model that ...
Eduardo Salinas, Arundhati Gupta, Jeffrey M. Sifford, Darby G. Oldenburg, Douglas W. White, J. Craig Forrest   +5 more
openaire   +4 more sources

Cross-species conservation of episome maintenance provides a basis for in vivo investigation of Kaposi's sarcoma herpesvirus LANA [PDF]

PLoS Pathogens, 2017
Copyright: © 2017 Habison et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source
A. Cerqueira, Sofia, Beauchemin, Chantal, Correia, Bruno, Habison, Aline C., Kaye, Kenneth M., McVey, Colin E., Pires de Miranda, Marta, Ponnusamy, Rajesh, Simas, J Pedro, Tan, Min, Usherwood, Edward J.   +10 more
core   +8 more sources

Unbiased Mutagenesis of MHV68 LANA Reveals a DNA-Binding Domain Required for LANA Function In Vitro and In Vivo

PLoS Pathogens, 2012
The Latency-Associated Nuclear Antigen (LANA), encoded by ORF73, is a conserved gene among the γ2-herpesviruses (rhadinoviruses). The Kaposi's Sarcoma-Associated Herpesvirus (KSHV) LANA is consistently expressed in KSHV-associated malignancies. In the case of the rodent γ2-herpesvirus, murine gammaherpesvirus 68 (MHV68), the LANA homolog (mLANA) is ...
Clinton R Paden, J Craig Forrest, Scott A Tibbetts, Samuel H Speck   +3 more
openaire   +4 more sources

Cross-Species Insights Into Gamma Herpesvirus Transcriptomes: Long-Read and Multi-Omics Perspectives. [PDF]

J Med Virol
ABSTRACT Comparative transcriptome analyses of gamma herpesviruses have been revolutionized by long‐read sequencing and integrative multi‐omics approaches, enabling unprecedented resolution of viral gene expression. Cross‐species studies of Kaposi's sarcoma‐associated herpesvirus (KSHV), Epstein–Barr virus (EBV), and murine gamma herpesvirus 68 (MHV68)
Shekhar R, McMahon S, Tibbetts SA, Flemington EK, Renne R.   +4 more
europepmc   +2 more sources

Eph receptor tyrosine kinases are functional entry receptors for murine gammaherpesvirus 68. [PDF]

PLoS Pathog
Interactions between viral glycoproteins and cellular receptors determine virus tropism and represent promising targets for vaccines. Eph receptor tyrosine kinases are conserved receptors for the human oncogenic gammaherpesviruses, Kaposi sarcoma ...
Großkopf AK, Tobiasson V, Krug LT.
europepmc   +2 more sources

Model Systems of Gammaherpesvirus Infection, Immunity, and Disease. [PDF]

J Med Virol
ABSTRACT Epstein‐Barr virus (EBV) and Kaposi's sarcoma‐associated herpesvirus (KSHV) are oncogenic human gammaherpesviruses (GHVs) associated with a broad spectrum of malignancies and chronic diseases. However, direct studies of these viruses in humans are limited by ethical constraints, technical challenges, and their strict species specificity.
Gupta A, Li R, Shair K, Gao SJ.
europepmc   +2 more sources

Preexisting helminth challenge exacerbates infection and reactivation of gammaherpesvirus in tissue resident macrophages. [PDF]

PLoS Pathog, 2023
Even though gammaherpesvirus and parasitic infections are endemic in parts of the world, there is a lack of understanding about the outcome of coinfection. In humans, coinfections usually occur sequentially, with fluctuating order and timing in different
Zarek CM, Dende C, Coronado J, Pendse M, Dryden P, Hooper LV, Reese TA.   +6 more
europepmc   +2 more sources

Early antiviral treatment following gammaherpesvirus-68 infection of the central nervous system prevents subsequent multiple sclerosis-like disease. [PDF]

J Neuroinflammation
Background Growing evidence indicates that Epstein-Barr virus (EBV), a gammaherpesvirus, plays a central role in the pathogenesis of multiple sclerosis (MS).
Muselman A, Kongara S, Hsu N, Aggarwal A, Yu J, Rajadas J, Engleman EG.   +6 more
europepmc   +2 more sources