Results 21 to 30 of about 1,936 (157)

A Bivalent mRNA Vaccine Efficiently Prevents Gammaherpesvirus Latent Infection. [PDF]

Vaccines (Basel)
Background: It is still challenging to develop effective vaccines against tumorigenic human gammaherpesviruses such as Epstein–Barr virus (EBV). A major obstacle is the lack of a small animal model that reproduces the natural infection course of human ...
Yin Y, Zang J, Shi H, Wang Z, Kuang L, Wang S, Wang H, Li N, Liang X, Huang Z.   +9 more
europepmc   +2 more sources

The infection of murine gammaherpesvirus-68 delays the early embryonic development of zebrafish

Reproduction and Breeding, 2023
Zebrafish is a model animal for aquaculture as well as bio-medicine. Murine gamma-herpesvirus 68 (MHV68) is widely regarded as a model for the study of human gamma herpesviruses such as Kaposi's sarcoma-associated herpesvirus (KSHV).
Jun Yan, Mengdie Chi, Jun Xiao, Meiling Liu, Hao Feng   +4 more
doaj   +1 more source

Gammaherpesvirus infection triggers the formation of tRNA fragments from premature tRNAs. [PDF]

mBio
Transfer RNAs (tRNAs) are fundamental for both cellular and viral gene expression during viral infection. In addition, mounting evidence supports the biological function for tRNA cleavage products, including the control of gene expression during ...
Manning AC, Bashir MM, Rapchak K, Huff CJ, Jimenez AR, Gonzalez S, Woodruff CL, Upton HE, Collins K, Lowe TM, Tucker JM.   +10 more
europepmc   +2 more sources

Animal models of human herpesvirus infection. [PDF]

Animal Model Exp Med
Human herpesvirus can infect humans and other vertebrates, primarily targeting the skin, mucous membranes, and neural tissues, thereby significantly impacting the health of both humans and animals. Animal models are crucial for studying virus pathogenesis, vaccine development, and drug testing.
Jia Z, Zhang D, Zhu L, Xue J.
europepmc   +2 more sources

Regulation of ribonucleoprotein condensates by RNase L during viral infection

WIREs RNA, Volume 14, Issue 4, July/August 2023., 2023
RNase L‐mediated mRNA decay inhibits stress granule assembly and promotes the assembly of RNase L‐dependent bodies. Abstract In response to viral infection, mammalian cells activate several innate immune pathways to antagonize viral gene expression. Upon recognition of viral double‐stranded RNA, protein kinase R (PKR) phosphorylates the alpha subunit ...
James M. Burke
wiley   +1 more source

Murine gamma-herpesvirus immortalization of fetal liver-derived B cells requires both the viral cyclin D homolog and latency-associated nuclear antigen. [PDF]

PLoS Pathogens, 2011
Human gammaherpesviruses are associated with the development of lymphoproliferative diseases and B cell lymphomas, particularly in immunosuppressed hosts.
Xiaozhen Liang, Clinton R Paden, Francine M Morales, Ryan P Powers, Joshy Jacob, Samuel H Speck   +5 more
doaj   +1 more source

25‐hydroxycholesterol inhibits human papillomavirus infection in cervical epithelial cells by perturbing cytoskeletal remodeling

Journal of Medical Virology, Volume 95, Issue 6, June 2023., 2023
Abstract Persistent high‐risk human papilloma virus (HR‐HPV) infection is the main risk factor for cervical cancer, threatening women's health. Despite growing prophylactic vaccination, annual cervical cancer cases are still increasing and show a trend of younger onset age. However, therapeutic approaches towards HPV infection are still limited.
Boning Li, Chen Hua, Pu Tian, Yiou Sha, Lu Zhang, Qian Wang, Lu Lu, Shibo Jiang, Long Sui   +8 more
wiley   +1 more source

Interleukin 16 contributes to gammaherpesvirus pathogenesis by inhibiting viral reactivation.

PLoS Pathogens, 2020
Gammaherpesviruses have evolved various strategies to take advantage of host cellular factors or signaling pathways to establish a lifelong latent infection.
Shuai Liu, Zhangmengxue Lei, Jie Li, Liu Wang, Ran Jia, Zhongshun Liu, Congwei Jiang, Ying Gao, Mu Liu, Linlin Kuang, Zhikang Qian, Dongming Zhou, Samuel H Speck, Xiaozhen Liang   +13 more
doaj   +1 more source

DESIGN AND GENERATION OF A RECOMBINANT GAMMAHERPESVIRUS ENCODING shRNA FROM A NATIVE VIRAL tRNA PROMOTER

Trakya University Journal of Natural Sciences, 2023
Gammaherpesviruses are associated with multiple types of tumor development and understanding the pathogenesis of these viruses has been the subject of various studies.
Scott Tibbetts, Mehmet Kara
doaj   +1 more source

Crosstalk between the Intestinal Virome and Other Components of the Microbiota, and Its Effect on Intestinal Mucosal Response and Diseases

Journal of Immunology Research, Volume 2022, Issue 1, 2022., 2022
In recent years, there has been ample evidence illustrating the effect of microbiota on gut immunity, homeostasis, and disease. Most of these studies have engaged more efforts in understanding the role of the bacteriome in gut mucosal immunity and disease.
Njinju Asaba Clinton, Sodiq Ayobami Hameed, Eugene Kusi Agyei, Joy Chinwendu Jacob, Victor Oyewale Oyebanji, Cyril Ekabe Jabea, Payam Behzadi   +6 more
wiley   +1 more source