Results 31 to 40 of about 1,936 (157)

Modified Cross‐Linking, Ligation, and Sequencing of Hybrids (qCLASH) to Identify MicroRNA Targets

Current Protocols, Volume 1, Issue 10, October 2021., 2021
Abstract This protocol was designed to identify microRNA (miRNA) targetomes from smaller‐input samples by performing a simplified workflow of the Cross‐Linking and Sequencing of Hybrids (CLASH) technique developed in the Tollervey group. In this ribonomics‐based technique, Cross‐Linking and Immunoprecipitation (CLIP) of Argonaute (Ago) is combined with
Lauren A. Gay, Peter C. Turner, Rolf Renne   +2 more
wiley   +1 more source

Interleukin 21 signaling in B cells is required for efficient establishment of murine gammaherpesvirus latency. [PDF]

PLoS Pathogens, 2015
The human gammaherpesviruses take advantage of normal B cell differentiation pathways to establish life-long infection in memory B cells. Murine gammaherpesvirus 68 (MHV68) infection of laboratory strains of mice also leads to life-long infection in ...
Christopher M Collins, Samuel H Speck
doaj   +1 more source

Co‐ and polymicrobial infections in the gut mucosa: The host–microbiota–pathogen perspective

Cellular Microbiology, Volume 23, Issue 2, February 2021., 2021
Abstract Infections in humans occur in the context of complex niches where the pathogen interacts with both the host microenvironment and immune response, and the symbiotic microbial community. The polymicrobial nature of many human infections adds a further layer of complexity.
Teresa Frisan
wiley   +1 more source

Vaccination with a Replication-Dead Murine Gammaherpesvirus Lacking Viral Pathogenesis Genes Inhibits WT Virus Infection. [PDF]

Viruses
Gammaherpesviruses are oncogenic pathogens that establish lifelong infections. There are no FDA-approved vaccines against Epstein–Barr virus or Kaposi sarcoma herpesvirus.
Mitra D, Oldenburg DG, Forrest JC, Krug LT.   +3 more
europepmc   +2 more sources

Tracking murine gammaherpesvirus 68 infection of germinal center B cells in vivo.

PLoS ONE, 2012
Infection of mice with murine gammaherpesvirus 68 (MHV68) provides a tractable small animal model to study various aspects of persistent gammaherpesvirus infection. We have previously utilized a transgenic MHV68 that expresses enhanced yellow fluorescent
Christopher M Collins, Samuel H Speck
doaj   +1 more source

Uracil-DNA glycosylase of murine gammaherpesvirus 68 binds cognate viral replication factors independently of its catalytic residues. [PDF]

mSphere, 2023
Herpesviruses are large double-stranded DNA viruses that encode core replication proteins and accessory factors involved in nucleotide metabolism and DNA repair.
Smith KR, Paul S, Dong Q, Anannya O, Oldenburg DG, Forrest JC, McBride KM, Krug LT.   +7 more
europepmc   +2 more sources

Latent gammaherpesvirus 68 infection induces distinct transcriptional changes in different organs [PDF]

, 2013
Previous studies identified a role for latent herpesvirus infection in cross-protection against infection and exacerbation of chronic inflammatory diseases. Here, we identified more than 500 genes differentially expressed in spleens, livers, or brains of
Canny, Susan P, Goel, Gautam, Reese, Tiffany A, Virgin, Herbert W, Xavier, Ramnik, Zhang, Xin   +5 more
core   +2 more sources

Rodent herpesvirus Peru encodes a secreted chemokine decoy receptor [PDF]

, 2013
Viruses have long been studied not only for their pathology and associated disease but also as model systems for understanding cellular and immunological processes. Rodent herpesvirus Peru (RHVP) is a recently characterized rhadinovirus related to murine
Alcami, Alcami, Alcami, Alcami, Alcami, Alejo, Alexander, Alexander-Brett, Arnold, Bahar, Bursill, Cardin, Cyster, D. H. Fremont, D. J. Lenschow, Dabbagh, Epperson, Esko, Graham, Herr, Hileman, Houser, Hughes, Hughes, Jensen, K. Monte, Kelley, Lalani, Lalani, Lateef, Lateef, Lau, Lau, Liu, Loh, Lucas, M. Cella, Maghazachi, Martin, Miley, Moser, Murphy, O. Y. Lubman, Proudfoot, Proudfoot, Pyo, Rice, Ruiz-Arguello, Russo, Seet, Seet, Strockbine, van Berkel, van Berkel, Viejo-Borbolla, Virgin, Wang, X. Wang, Y. H. Huang   +58 more
core   +2 more sources

Murine gammaherpesvirus M2 antigen modulates splenic B cell activation and terminal differentiation in vivo. [PDF]

PLoS Pathogens, 2017
Murine gammaherpesvirus 68 (MHV68) infection of laboratory strains of mice has provided a tractable small animal model for dissecting gammaherpesvirus pathogenesis.
Shariya Terrell, Samuel H Speck
doaj   +1 more source

Tick-Borne Transmission of Murine Gammaherpesvirus 68

Frontiers in Cellular and Infection Microbiology, 2017
Herpesviruses are a large group of DNA viruses infecting mainly vertebrates. Murine gammaherpesvirus 68 (MHV68) is often used as a model in studies of the pathogenesis of clinically important human gammaherpesviruses such as Epstein-Barr virus and Kaposi'
Valeria Hajnická, Marcela Kúdelová, Iveta Štibrániová, Mirko Slovák, Pavlína Bartíková, Zuzana Halásová, Peter Pančík, Petra Belvončíková, Michaela Vrbová, Viera Holíková, Rosemary S. Hails, Patricia A. Nuttall, Patricia A. Nuttall   +12 more
doaj   +1 more source