Cell Reports, 2012 To study the CD8(+) T cell response against a mouse γ-herpes virus, we generated K(b)-MHV-68-ORF8(604-612)RAG(-/-) CD8(+) T cell receptor transnuclear (TN) mice as a source of virus-specific CD8(+) T cells. K(b)-ORF8-Tet(+) CD8(+) T cells, expanded in the course of a resolving MHV-68 infection, served as a source of nucleus donors.
Sehrawat, Sharvan +8 more
openaire +6 more sources
Pervasive transcription of a herpesvirus genome generates functionally important RNAs [PDF]
, 2014 Pervasive transcription is observed in a wide range of organisms, including humans, mice, and viruses, but the functional significance of the resulting transcripts remains uncertain.
Canny, Susan P +7 more
core +2 more sources
Virus-Encoded MicroRNAs Facilitate Gammaherpesvirus Latency and Pathogenesis
mBio, 2014 Gammaherpesviruses, including Epstein-Barr virus (EBV), Kaposi sarcoma-associated herpesvirus (KSHV, or HHV-8), and murine gammaherpesvirus 68 (MHV68, γHV68, or MuHV-4), are B cell-tropic pathogens that each encode at least 12 microRNAs (miRNAs).
Emily R. Feldman +8 more
doaj +1 more source
Crystal structure of the tegument protein UL82 (pp71) from human cytomegalovirus. [PDF]
Protein SciAbstract Human cytomegalovirus (HCMV) is an opportunistic pathogen that infects a majority of the world population. It may cause severe disease in immunocompromised people and lead to pregnancy loss or grave disabilities of the fetus upon congenital infection.
Eberhage J +9 more
europepmc +2 more sources
An RS Motif within the Epstein-Barr Virus BLRF2 Tegument Protein Is Phosphorylated by SRPK2 and Is Important for Viral Replication [PDF]
, 2013 Epstein-Barr virus (EBV) is a gammaherpesvirus that causes infectious mononucleosis, B cell lymphomas, and nasopharyngeal carcinoma. Many of the genes required for EBV virion morphogenesis are found in all herpesviruses, but some are specific to ...
Adelmant, Guillaume +9 more
core +3 more sources
The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection. [PDF]
, 2015 Journal ArticleTGFβ-ALK5 pro-fibrotic signalling and herpesvirus infections have been implicated in the pathogenesis and exacerbation of pulmonary fibrosis. In this study we addressed the role of TGFβ-ALK5 signalling during the progression of fibrosis in
Alexander, RE +8 more
core +2 more sources
Viral pseudoenzymes in infection and immunity
The FEBS Journal, Volume 287, Issue 19, Page 4300-4309, October 2020., 2020 Viral pseudoenzymes are represented by enzyme‐deficient homologs of glutamine amidotransferase (GAT), kinase, and superoxide dismutase that modulate the signaling output in immune defense, viral genome replication, and cell proliferation, respectively.
Ting‐Yu Wang +4 more
wiley +1 more source
Murine cytomegalovirus protein pM92 Is a conserved regulator of viral late gene expression [PDF]
, 2013 In this study, we report that murine cytomegalovirus (MCMV) protein pM92 regulates viral late gene expression during virus infection. Previously, we have shown that MCMV protein pM79 and its human cytomegalovirus (HCMV) homologue pUL79 are required for ...
Chapa, Travis J +3 more
core +2 more sources
PLoS ONE, 2014 Passage through the eukaryotic cell cycle is regulated by the activity of cyclins and their cyclin-dependent kinase partners. Rhadinoviruses, such as Kaposi's sarcoma-associated herpesvirus (KSHV) and murine gammaherpesvirus 68 (MHV68), encode a viral ...
Francine M Scott, Samuel H Speck
doaj +1 more source
Gammaherpesvirus-driven plasma cell differentiation regulates virus reactivation from latently infected B lymphocytes. [PDF]
PLoS Pathogens, 2009 Gammaherpesviruses chronically infect their host and are tightly associated with the development of lymphoproliferative diseases and lymphomas, as well as several other types of cancer.
Xiaozhen Liang +4 more
doaj +1 more source