Results 51 to 60 of about 1,936 (157)

RIP1 kinase activity is critical for skin inflammation but not for viral propagation

Journal of Leukocyte Biology, Volume 107, Issue 6, Page 941-952, June 2020., 2020
Inhibiting RIP1 has benefits to skin inflammation but not certain viral infections. Abstract Receptor interacting protein kinase 1 (RIP1) is a critical effector of inflammatory responses and cell death activation. Cell death pathways regulated by RIP1 include caspase‐dependent apoptosis and caspase‐independent necroptosis.
Joshua D. Webster, Youngsu C. Kwon, Summer Park, Hua Zhang, Nick Corr, Nina Ljumanovic, Adeyemi O. Adedeji, Eugene Varfolomeev, Tatiana Goncharov, Jessica Preston, Sara F. Santagostino, Snahel Patel, Min Xu, Jonathan Maher, Brent S. McKenzie, Domagoj Vucic   +15 more
wiley   +1 more source

Epstein-Barr virus IL-10 gene expression by a recombinant murine gammaherpesvirus in vivo enhances acute pathogenicity but does not affect latency or reactivation. [PDF]

, 2014
BackgroundMany viral genes affect cytokine function within infected hosts, with interleukin 10 (IL-10) as a commonly targeted mediator. Epstein-Barr virus (EBV) encodes an IL-10 homologue (vIL-10) expressed during productive (lytic) infection and induces
Greer, Kimberly A, Lindquester, Gary J, Sample, Jeffery T, Stewart, James P   +3 more
core   +1 more source

Regulation of cGAS‐Mediated Immune Responses and Immunotherapy

Advanced Science, Volume 7, Issue 6, March 18, 2020., 2020
The cGAS‐STING pathway is central to innate immunity and must be tightly regulated. cGAS performs essential roles in numerous immune functions such as DNA sensing, antiviral defense, antitumor immunity, senescence, and DNA repair. Aberrant cGAS activation leads to autoimmune and inflammatory diseases.
Abdullah F. U. H. Saeed, Xinglin Ruan, Hongxin Guan, Jingqian Su, Songying Ouyang   +4 more
wiley   +1 more source

Transnuclear CD8 T cells specific for the immunodominant epitope Gra6 lower acute-phase Toxoplasma gondii burden. [PDF]

, 2016
We generated a CD8 T-cell receptor (TCR) transnuclear (TN) mouse specific to the Ld -restricted immunodominant epitope of GRA6 from Toxoplasma gondii as a source of cells to facilitate further investigation into the CD8 T-cell-mediated response against ...
Blanchard, Nicolas, Dougan, Stephanie K, Frickel, Eva-Maria, Jackson, John, Ploegh, Hidde, Sanecka, Anna, Shastri, Nilabh, Yoshida, Nagisa   +7 more
core   +2 more sources

Multiple Roles of 25‐Hydroxycholesterol in Lipid Metabolism, Antivirus Process, Inflammatory Response, and Cell Survival

Oxidative Medicine and Cellular Longevity, Volume 2020, Issue 1, 2020., 2020
As an essential lipid, cholesterol is of great value in keeping cell homeostasis, being the precursor of bile acid and steroid hormones, and stabilizing membrane lipid rafts. As a kind of cholesterol metabolite produced by enzymatic or radical process, oxysterols have drawn much attention in the last decades.
Qin Cao, Zhongzhong Liu, Yan Xiong, Zibiao Zhong, Qifa Ye, Ilaria Peluso   +5 more
wiley   +1 more source

A Novel Peptide-Based SILAC Method to Identify the Posttranslational Modifications Provides Evidence for Unconventional Ubiquitination in the ER-Associated Degradation Pathway. [PDF]

, 2013
The endoplasmic reticulum-associated degradation (ERAD) pathway is responsible for disposing misfolded proteins from the endoplasmic reticulum by inducing their ubiquitination and degradation.
Anania, Veronica, Bustos, Daisy, COSCOY, Laurent, Kirkpatrick, Donald, Lill, Jennie   +4 more
core   +3 more sources

Gammaherpesvirus Co-infection with Malaria Suppresses Anti-parasitic Humoral Immunity. [PDF]

PLoS Pathogens, 2015
Immunity to non-cerebral severe malaria is estimated to occur within 1-2 infections in areas of endemic transmission for Plasmodium falciparum. Yet, nearly 20% of infected children die annually as a result of severe malaria.
Caline G Matar, Neil R Anthony, Brigid M O'Flaherty, Nathan T Jacobs, Lalita Priyamvada, Christian R Engwerda, Samuel H Speck, Tracey J Lamb   +7 more
doaj   +1 more source

The zebrafish xenograft platform-A novel tool for modeling KSHV-associated diseases [PDF]

, 2019
Kaposi\u27s sarcoma associated-herpesvirus (KSHV, also known as human herpesvirus-8) is a gammaherpesvirus that establishes life-long infection in human B lymphocytes.
Berman, Jason N, Coombs, Andrew J, Dellaire, Graham, Druley, Todd E, Ha, Michael N, McCormick, Craig, Melong, Nicole, O\u27Leary, David, Pringle, Eric S, Robinson, Carolyn-Ann, Veinotte, Chansey, Wertman, Jaime, Young, Andrew L   +12 more
core   +2 more sources

Regulation of microRNA biogenesis and turnover by animals and their viruses [PDF]

, 2013
Item does not contain fulltextMicroRNAs (miRNAs) are a ubiquitous component of gene regulatory networks that modulate the precise amounts of proteins expressed in a cell.
A Baccarini, A Giner, A Grishok, A Grundhoff, A Khvorova, A Nayak, A Rybak, A Rybak, A Varble, AA Millar, AA Saraiya, AD Haase, AD Scadden, AE Pasquinelli, AH Buck, AJ Chen, AM Brownawell, AM Burroughs, AM Monteys, Amy H. Buck, AS Flynt, B Berry, B Xhemalce, B Yu, B Yu, BD Adams, BN Davis, BN Davis, BR Cullen, BS Heale, C Cole, C Ender, C Okada, C Xiao, CD Malone, CH Lecellier, CP Singh, CS Sullivan, CY Chen, D Bortolamiol, D Cazalla, D Cazalla, D Cifuentes, D Grimm, D O’Carroll, DG Zisoulis, DJ Luciano, DL Ouellet, DM Burns, DP Bartel, DS Schwarz, E Bernstein, E Bucher, E Koscianska, E Lund, E Piskounova, E Piskounova, E Rooij van, EA Glazov, EG Moss, EJ Chapman, ES Cenik, F Ibrahim, F Jiang, F Ozsolak, F Rau, G Fabozzi, G Hutvagner, G Michlewski, G Michlewski, G Ren, G Schott, G Siegel, G Sun, GB Robb, GM Borchert, GM Schratt, H Cerutti, H Hemmes, H Iizasa, H Li, H Rouha, H Wu, HI Suzuki, HI Suzuki, HP Bogerd, HR Chiang, HW Hwang, I Gy, I Heo, I Heo, I Heo, J Azevedo, J Haasnoot, J Haasnoot, J Han, J Han, J Krol, J Li, J Lin, JA Chao, JB Morel, JC Wolfswinkel van, JE Babiarz, JE Park, JG Ruby, JJ Forman, JJ Gruber, JL Umbach, JM Pawlicki, JM Vargason, JO Westholm, JP Hagan, JS Shapiro, JS Yang, JS Yang, JS Yang, JT Mendell, JT Mierlo van, K Forstemann, K Jazdzewski, K Nishikura, K Okamura, K Okamura, K Saito, K Yamagata, K Ye, KD Kasschau, KH Kok, KW Diebel, L Lakatos, L Lakatos, L Marcinowski, LA O’Neill, LM Kamminga, LR Sabin, M Ballarino, M Ghildiyal, M Grinberg, M Hussain, M Morlando, M Pazhouhandeh, M Trabucchi, MA Newman, MA Newman, MD Horwich, MF Thomas, MG Andersson, MJ Blow, MJ Schmidt, MO Delgadillo, MP Gantier, MR Fabian, MR Jones, MS Ho, MT Blahna, MT Bohnsack, N Baumberger, N Iwai, NJ Lehrbach, NR Choudhury, O Barad, O Voinnet, OS Rissland, P Briata, P Dunoyer, P Landgraf, P Parameswaran, P Rajasethupathy, P Sethi, Pascal Miesen, PS Shah, R Aliyari, R Duan, R Harnprasopwat, R Lu, R Schickel, R Tang, R Triboulet, R Yi, RC Friedman, RF Ketting, RI Gregory, RI Gregory, RL Skalsky, Ronald P. van Rij, RP Kincaid, RP Rij van, RP Rij van, RW Carthew, S Backes, S Bail, S Banerjee, S Chatterjee, S Chatterjee, S Cheloufi, S Diederichs, S Guil, S Hellwig, S Kadener, S Kawai, S Lu, S Lu, S Macias, S Omoto, S Omoto, S Pfeffer, S Qian, S Rudel, S Ruegger, S Sakamoto, SI Ashraf, SK Das, SK Wyman, SL Ameres, SM Hammond, SN Bhattacharyya, SR Viswanathan, SS Soldan, SW Ding, SW Knight, T Csorba, T Csorba, T Fukuda, T Katoh, TC Chang, TP Chendrimada, V Ambros, V Libri, V Ramachandran, Valentina Libri, VN Kim, VS Mahajan, W Yang, WX Li, X Wang, X Zhang, X Zhang, Y Bennasser, Y Bennasser, Y Bennasser, Y Huang, Y Kawahara, Y Kawahara, Y Kawahara, Y Kawahara, Y Lee, Y Lee, Y Lee, Y Nam, Y Tomari, Y Yao, Y Zhao, YK Kim, YS Lee, YT Lin, Z Hu, Z Merai, Z Merai, Z Mourelatos, Z Paroo, Z Yang, Z Zhang, ZS Kai   +263 more
core   +1 more source

Twist: a regulator of epithelial-mesenchymal transition in lung fibrosis. [PDF]

PLoS ONE, 2009
Several studies have implicated viral infection as an important factor in the pathogenesis of IPF and related fibrotic lung disorders. Viruses are thought to cause epithelial cell injury and promote epithelial-mesenchymal transition (EMT), a process ...
Veronika Pozharskaya, Edilson Torres-González, Mauricio Rojas, Anthony Gal, Minal Amin, Sheila Dollard, Jesse Roman, Arlene A Stecenko, Ana L Mora   +8 more
doaj   +1 more source