Results 61 to 70 of about 1,936 (157)

Breaking Bad:How Viruses Subvert the Cell Cycle [PDF]

, 2018
Interactions between the host and viruses during the course of their co-evolution have not only shaped cellular function and the immune system, but also the counter measures employed by viruses.
Roberto Bruzzone, Roberto Bruzzone, Sumana Sanyal, Sumana Sanyal, Ying Fan, Ying Fan   +5 more
core   +3 more sources

Characterization of omental immune aggregates during establishment of a latent gammaherpesvirus infection. [PDF]

PLoS ONE, 2012
Herpesviruses are characterized by their ability to establish lifelong latent infection. The gammaherpesvirus subfamily is distinguished by lymphotropism, establishing and maintaining latent infection predominantly in B lymphocytes.
Kathleen S Gray, Christopher M Collins, Samuel H Speck   +2 more
doaj   +1 more source

Maternal Herpesviridae infection during pregnancy alters midbrain dopaminergic signatures in adult offspring

Neurobiology of Disease, 2022
Background: Motor symptoms of Parkinson's disease (PD) are apparent after a high proportion of dopamine neurons in the substantia nigra have degenerated.
Amanda R. Burmeister, Juozas Gordevicius, Emmanuel N. Paul, Christina Houck, Sonia George, Martha L. Escobar Galvis, Qiong Sha, Patrik Brundin, J. Andrew Pospisilik, Karen Racicot, Lena Brundin   +10 more
doaj   +1 more source

Viral Takeover of the Host Ubiquitin System [PDF]

, 2011
Like the other more well-characterized post-translational modifications (phosphorylation, methylation, acetylation, acylation, etc.), the attachment of the 76 amino acid ubiquitin (Ub) protein to substrates has been shown to govern countless cellular ...
Jean K. Gustin, Ashlee V. Moses, Klaus Früh, Janet L. Douglas   +3 more
core   +1 more source

Expansion of murine gammaherpesvirus latently infected B cells requires T follicular help.

PLoS Pathogens, 2014
X linked lymphoproliferative disease (XLP) is an inherited immunodeficiency resulting from mutations in the gene encoding the slam associated protein (SAP).
Christopher M Collins, Samuel H Speck
doaj   +1 more source

RNA-guided gene editing of the murine gammaherpesvirus 68 genome reduces infectious virus production.

PLoS ONE, 2021
Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV) are cancer-causing viruses that establish lifelong infections in humans. Gene editing using the Cas9-guideRNA (gRNA) CRISPR system has been applied to decrease the latent load of EBV in human
Hui-Chen Chang Foreman, Varvara Kirillov, Gabrielle Paniccia, Demetra Catalano, Trevor Andrunik, Swati Gupta, Laurie T Krug, Yue Zhang   +7 more
doaj   +1 more source

Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell [PDF]

, 2012
During the primary response, the commitment of the CD8(+) T cell to Blimp-1 expression and the terminal differentiation that Blimp-1 induces must be timed so as not to impair the process of clonal expansion. We determined whether the Hippo pathway, which
A. Hoffmann, Bachmann, Bachmann, Bachmann, Bannard, Camargo, Chai, Choi, Cretney, D. T. Fearon, Dong, Feau, Gong, H. Lingel, Harrington, Hegel, J. E. D. Thaventhiran, Kalia, Kallies, Katagiri, Khanna, Kwon, L. Magiera, Lee, M. Brunner-Weinzierl, M. de la Roche, Nishioka, Pearce, Pipkin, Rao, Russ, Rutishauser, Sabatos, Schlegelmilch, Sun, Taylor, Turner, Voehringer, Waterhouse, Williams, Yeo, Zhao, Zhou   +42 more
core   +1 more source

Phosphoproteomic analyses reveal signaling pathways that facilitate lytic gammaherpesvirus replication. [PDF]

PLoS Pathogens, 2013
Lytic gammaherpesvirus (GHV) replication facilitates the establishment of lifelong latent infection, which places the infected host at risk for numerous cancers. As obligate intracellular parasites, GHVs must control and usurp cellular signaling pathways
James A Stahl, Shweta S Chavan, Jeffrey M Sifford, Veronica MacLeod, Daniel E Voth, Ricky D Edmondson, J Craig Forrest   +6 more
doaj   +1 more source

CD8+ T Cell Response to Gammaherpesvirus Infection Mediates Inflammation and Fibrosis in Interferon Gamma Receptor-Deficient Mice.

PLoS ONE, 2015
Idiopathic pulmonary fibrosis (IPF), one of the most severe interstitial lung diseases, is a progressive fibrotic disorder of unknown etiology. However, there is growing appreciation for the role of viral infection in disease induction and/or progression.
Brigid M O'Flaherty, Caline G Matar, Brian S Wakeman, AnaPatricia Garcia, Carol A Wilke, Cynthia L Courtney, Bethany B Moore, Samuel H Speck   +7 more
doaj   +1 more source

Role of Src homology domain binding in signaling complexes assembled by the murid γ-herpesvirus M2 protein [PDF]

, 2016
γ-Herpesviruses express proteins that modulate B lymphocyte signaling to achieve persistent latent infections. One such protein is the M2 latency-associated protein encoded by the murid herpesvirus-4.
Bustelo, Xosé R., Lopes, Filipa B., McVey, Colin E., Pires de Miranda, Marta, Simas, J. Pedro   +4 more
core   +1 more source