Results 71 to 80 of about 1,936 (157)

A gammaherpesvirus cooperates with interferon-alpha/beta-induced IRF2 to halt viral replication, control reactivation, and minimize host lethality. [PDF]

PLoS Pathogens, 2011
The gammaherpesviruses, including Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), establish latency in memory B lymphocytes and promote lymphoproliferative disease in immunocompromised individuals.
Pratyusha Mandal, Bridgette E Krueger, Darby Oldenburg, Katherine A Andry, R Suzanne Beard, Douglas W White, Erik S Barton   +6 more
doaj   +1 more source

Targeted Protein Degradation of the Latency‐Associated Nuclear Antigen Evicts Kaposi Sarcoma‐Associated Herpesvirus Episomes From Infected Cells In Vitro

Journal of Medical Virology, Volume 97, Issue 12, December 2025.
ABSTRACT Kaposi sarcoma‐associated herpesvirus (KSHV), a gamma‐herpesvirus, is the main etiological agent of several tumors, including Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL). The large, double‐stranded viral genome of KSHV is maintained as a latent episome in the nucleus of host cells, where a small subset of viral genes is expressed
Sarah McMahon, Maha Amer, Brooke Hall, Ritu Shekhar, Rolf Renne   +4 more
wiley   +1 more source

2020 Annual World Congress of the Pulmonary Vascular Research Institute

, 2021
Pulmonary Circulation, Volume 11, Issue 2, Page 1-75, April-June 2021.
wiley   +1 more source

Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter [PDF]

, 2014
Mammals are coinfected by multiple pathogens that interact through unknown mechanisms. We found that helminth infection, characterized by the induction of the cytokine interleukin-4 (IL-4) and the activation of the transcription factor Stat6, reactivated
Artyomov, M.N., Buck, M.D., Choi, H.S., Goel, G., Huang, S.C., Hufford, M.M., Jezewski, A., Kambal, A., Kaplan, M.H., Liu, C.Y., Murray, P.J., Pearce, E.J., Reese, T.A., Renne, R., Speck, S.H., Virgin, H.W., Wakeman, B.S., Xavier, R.J., Zhang, X.   +18 more
core   +1 more source

Identification of murine gammaherpesvirus 68 miRNA-mRNA hybrids reveals miRNA target conservation among gammaherpesviruses including host translation and protein modification machinery.

PLoS Pathogens, 2019
Gammaherpesviruses, including the human pathogens Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), establish lifelong latent infection in B cells and are associated with a variety of tumors. In addition to protein coding genes,
Whitney L Bullard, Mehmet Kara, Lauren A Gay, Sunantha Sethuraman, Yiping Wang, Shreya Nirmalan, Alim Esemenli, April Feswick, Brett A Hoffman, Rolf Renne, Scott A Tibbetts   +10 more
doaj   +1 more source

Galectin-3 Regulates γ-Herpesvirus Specific CD8 T Cell Immunity

iScience, 2018
Summary: To gain insights into the molecular mechanisms and pathways involved in the activation of γ-herpesvirus (MHV68)-specific T cell receptor transnuclear (TN) CD8+ T cells, we performed a comprehensive transcriptomic analysis.
Manpreet Kaur, Dhaneshwar Kumar, Vincent Butty, Sudhakar Singh, Alexandre Esteban, Gerald R. Fink, Hidde L. Ploegh, Sharvan Sehrawat   +7 more
doaj   +1 more source

T Cell-Specific STAT1 Expression Promotes Lytic Replication and Supports the Establishment of Gammaherpesvirus Latent Reservoir in Splenic B Cells

mBio, 2022
Gammaherpesviruses establish lifelong infections in most vertebrate species, including humans and rodents, and are associated with cancers, including B cell lymphomas.
P. A. Sylvester, C. N. Jondle, D. L. Schmalzriedt, B. N. Dittel, V. L. Tarakanova   +4 more
doaj   +1 more source

Role of Viral miRNAs and Epigenetic Modifications in Epstein‐Barr Virus‐Associated Gastric Carcinogenesis

Oxidative Medicine and Cellular Longevity, Volume 2016, Issue 1, 2016., 2016
MicroRNAs are short (21–23 nucleotides), noncoding RNAs that typically silence posttranscriptional gene expression through interaction with target messenger RNAs. Currently, miRNAs have been identified in almost all studied multicellular eukaryotes in the plant and animal kingdoms.
Aldo Giudice, Giovanni D’Arena, Anna Crispo, Mario Felice Tecce, Flavia Nocerino, Maria Grimaldi, Emanuela Rotondo, Anna Maria D’Ursi, Mario Scrima, Massimiliano Galdiero, Gennaro Ciliberto, Mario Capunzo, Gianluigi Franci, Antonio Barbieri, Sabrina Bimonte, Maurizio Montella, Denis Delic   +16 more
wiley   +1 more source

Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus [PDF]

, 2013
Influenza A virus-specific B lymphocytes and the antibodies they produce protect against infection. However, the outcome of interactions between an influenza haemagglutinin-specific B cell via its receptor (BCR) and virus is unclear. Through somatic cell
Ana M. Avalos, Arwen F. Altenburg, B Manicassamy, B Moltedo, B Moltedo, Chunguang Guo, CI Thompson, DC Wiley, DJ Morgan, Frederick W. Alt, Hidde L. Ploegh, HM Joo, Jessica R. Ingram, JM Antos, Joseph Ashour, Juan Jose Cragnolini, K Simons, M Boes, Marta Barisa, Maximilian W. Popp, MC Pedroso de Lima, MD Witte, MW Popp, MW Popp, NE Harwood, O Kirak, O Kirak, PD Jones, Roos A. Karssemeijer, RT Huang, Rudolf Jaenisch, S Kishigami, S Sehrawat, SA Valkenburg, SJ Stray, SK Dougan, SK Dougan, SL Londrigan, Stephanie K. Dougan, T Eierhoff, T Onodera, VC Chu   +41 more
core   +2 more sources

Global mRNA degradation during lytic gammaherpesvirus infection contributes to establishment of viral latency. [PDF]

PLoS Pathogens, 2011
During a lytic gammaherpesvirus infection, host gene expression is severely restricted by the global degradation and altered 3' end processing of mRNA. This host shutoff phenotype is orchestrated by the viral SOX protein, yet its functional significance ...
Justin M Richner, Karen Clyde, Andrea C Pezda, Benson Yee Hin Cheng, Tina Wang, G Renuka Kumar, Sergio Covarrubias, Laurent Coscoy, Britt Glaunsinger   +8 more
doaj   +1 more source