The innate and T-cell mediated immune response during acute and chronic gammaherpesvirus infection
Frontiers in Cellular and Infection Microbiology, 2023 Immediately after entry into host cells, viruses are sensed by the innate immune system, leading to the activation of innate antiviral effector mechanisms including the type I interferon (IFN) response and natural killer (NK) cells.
Viktoria Rex +7 more
doaj +1 more source
British Journal of Pharmacology, Volume 182, Issue 1, Page 26-51, January 2025.G protein‐coupled receptors (GPCRs) are pivotal in cellular signalling and drug targeting. Herpesviruses encode GPCRs (vGPCRs) to manipulate cellular signalling, thereby regulating various aspects of the virus life cycle, such as viral spreading and immune evasion.
Naotaka Tsutsumi +6 more
wiley +1 more source
Suppressing fatty acid synthase by type I interferon and chemical inhibitors as a broad spectrum anti-viral strategy against SARS-CoV-2 [PDF]
, 2022 SARS-CoV-2 is an emerging viral pathogen and a major global public health challenge since December of 2019, with limited effective treatments throughout the pandemic.
Aliyari, Saba R +3 more
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Annals of the Child Neurology Society, Volume 2, Issue 3, Page 235-241, September 2024.Abstract Objective Herpes simplex virus (HSV) encephalitis can be associated with many secondary neurological complications, but having multiple episodes of recurrent neurological complications is rare in an individual. Understanding the course of each complication can reduce time to diagnosis and adequate treatment. Additionally, we postulate the role
Rutu M. Dave +3 more
wiley +1 more source
The contribution of gamma-herpes viruses on the development of CD30+ B cell lymphomas: research and investigation in a mouse model [PDF]
, 2023 EBV and KSHV are two gammaherpesviruses that are known to be highly associated with CD30-positive lymphomas, such as Hodgkin lymphomas. Whether deregulated CD30-signaling cooperates with herpes viral infections in tumorigenesis is not well understood ...
Chew, Zakir Hassan
core
Heterologous immunity triggered by a single, latent virus in Mus musculus: combined costimulation- and adhesion- blockade decrease rejection. [PDF]
PLoS ONE, 2013 The mechanisms underlying latent-virus-mediated heterologous immunity, and subsequent transplant rejection, especially in the setting of T cell costimulation blockade, remain undetermined. To address this, we have utilized MHV68 to develop a rodent model
Jonathan M Beus +11 more
doaj +1 more source
cGAS–STING, an important signaling pathway in diseases and their therapy
MedComm, Volume 5, Issue 4, April 2024.cGAS–STING signaling pathway was discovered in 2013. With so many years of in‐depth research on cGAS–STING, people have realized that cGAS–STING plays a key role in human diseases, particularly DNA‐triggered inflammatory diseases and cancers. This review summarize the ancient origin, triggers, transduction, and regulating mechanisms of the cGAS–STING ...
Qijie Li +5 more
wiley +1 more source
mSphere, 2016 Recent intense investigations have uncovered important functions for a diverse array of novel noncoding RNA (ncRNA) species, including microRNAs (miRNAs) and long noncoding RNAs.
Emily R. Feldman +9 more
doaj +1 more source
Murine Gammaherpesvirus 68 LANA Acts on Terminal Repeat DNA To Mediate Episome Persistence [PDF]
, 2012 Murine gammaherpesvirus 68 (MHV68) ORF73 (mLANA) has sequence homology to Kaposi’s sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA).
Beauchemin, Chantal +4 more
core +2 more sources
Retinoid X receptor α attenuates host antiviral response by suppressing type I interferon. [PDF]
, 2014 The retinoid X receptor α (RXRα), a key nuclear receptor in metabolic processes, is downregulated during host antiviral response. However, the roles of RXRα in host antiviral response are unknown.
Arora, Neda +9 more
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