Results 11 to 20 of about 20,210 (217)

Inbred Strain-Specific Response to Biglycan Deficiency in the Cortical Bone of C57BL6/129 and C3H/He Mice [PDF]

Journal of Bone and Mineral Research, 2009
Abstract Inbred strain-specific differences in mice exist in bone cross-sectional geometry, mechanical properties, and indices of bone formation. Inbred strain-specific responses to external stimuli also exist, but the role of background strain in response to genetic deletion is not fully understood.
Wallace, Joseph M., Golcuk, Kurtulus, Morris, Michael D., Kohn, David H.   +3 more
openaire   +4 more sources

Differential Effects of Bone Structural and Material Properties on Bone Competence in C57BL/6 and C3H/He Inbred Strains of Mice [PDF]

Calcified Tissue International, 2008
Calcified Tissue International, 83 (1)
Voide, Romain, van Lenthe, G Harry, Müller, Ralph   +2 more
openaire   +7 more sources

Quantitative Trait Loci for Femoral and Lumbar Vertebral Bone Mineral Density in C57BL/6J and C3H/HeJ Inbred Strains of Mice [PDF]

Journal of Bone and Mineral Research, 2001
Abstract Significant differences in vertebral (9%) and femoral (50%) adult bone mineral density (BMD) between the C57BL/6J (B6) and C3H/HeJ (C3H) inbred strains of mice have been subjected to genetic analyses for quantitative trait loci (QTL).
Beamer, W G, Shultz, K L, Donahue, L R, Churchill, G A, Sen, S, Wergedal, J R, Baylink, D J, Rosen, C J   +7 more
openaire   +5 more sources

Mouse models for pseudoxanthoma elasticum: genetic and dietary modulation of the ectopic mineralization phenotypes. [PDF]

PLoS ONE, 2014
Pseudoxanthoma elasticum (PXE), a heritable ectopic mineralization disorder, is caused by mutations in the ABCC6 gene. Null mice (Abcc6(-/-) ) recapitulate the genetic, histopathologic and ultrastructural features of PXE, and they demonstrate early and ...
Qiaoli Li, Haitao Guo, David W Chou, Annerose Berndt, John P Sundberg, Jouni Uitto   +5 more
doaj   +5 more sources

A DIFFERENCE IN SKELETAL TYPE BETWEEN RECIPROCAL HYBRIDS OF TWO INBRED STRAINS OF MICE (C57 BLK AND C3H) [PDF]

Genetics, 1951
E L, Green, W L, Russell
openaire   +4 more sources

Bone Loss and TLR4 Signals Contribute Independently to B Lineage Aging. [PDF]

Aging Cell
The prevailing view is that the age‐related decline of B lymphopoiesis is due to increased inhibitory signals in the marrow environment. Our data show that the loss of salutary ones, such as those from bone, primarily drives the loss of B cell progenitors with age.
Baker E, Montecino-Rodriguez E, Xu S, Tetradis S, Rouault A, Estrada OI, Dorshkind K.   +6 more
europepmc   +2 more sources

Insights Into Complex Murine Models of Allergy and Anaphylaxis: The Central Role of IgE and Mast Cells in Advancing Human Therapies. [PDF]

Eur J Immunol
Murine allergy model outcomes differ by sensitization route, allergen type, and mouse strain, influencing mechanisms such as IgE and mast cell involvement and the therapeutic relevance of each model. Understanding how experimental parameters shape outcomes is essential for selecting appropriate models and effectively translating findings to clinical ...
Nagata Y, Suzuki R.
europepmc   +2 more sources

Lymphatic topology reveals a novel intranodal lympho-venous shunt. [PDF]

J Pathol
Abstract Understanding the lymphatic network is crucial for immunological research. Currently, a complete map of lymphatic drainage in mice is lacking. We present a detailed lymphatic system flow dynamic of two mouse strains with swollen lymph nodes (LNs), using region‐specific tracer injection and high‐resolution micro‐CT imaging to characterize LN ...
Sukhbaatar A, Mishra R, Nakamura A, Mori S, Sugiura T, Kodama T.   +5 more
europepmc   +2 more sources

Mapping genetic determinants of host susceptibility to Pseudomonas aeruginosa lung infection in mice. [PDF]

, 2016
Background: P. aeruginosa is one of the top three causes of opportunistic human bacterial infections. The remarkable variability in the clinical outcomes of this infection is thought to be associated with genetic predisposition.
A Bragonzi, A Bragonzi, A Bragonzi, A Corken, A Darvasi, Alessandra Bragonzi, C Cigana, C Morissette, C Morissette, CC Elbers, Cristina Cigana, CS Haley, D Nguyen, DL Demeo, DM Menge, E Amiel, EE Smith, F Iraqi, F Iraqi, FA Iraqi, FA Iraqi, Fuad A. Iraqi, GA Churchill, GR Cutting, GS Cooke, H Shinohara, I Bianconi, Ida De Fino, J Dupuis, JB Lyczak, JE Pennington, JM Collaco, K Sapru, K Tremblay, Karl W. Broman, KW Broman, L Guillot, LD Hazlett, Lorenza Spagnuolo, M Hernandez-Valladares, M Munoz, M Simone De, M Tam, M Verdrengh, MA Jong de, Maura De Simone, ML Drumm, N Lorè, NI Lore, Nicola Ivan Lorè, R Mashima, R Mashima, R Williams, S Aerts, S Gruenheid, S Worgall, SL Cheng, SL Gellatly, SM Vidal, TT Wu, V DeRose, Y Moreau, Y Zhan   +62 more
core   +3 more sources

Trabecular and Cortical Bone of Growing C3H Mice Is Highly Responsive to the Removal of Weightbearing.

PLoS ONE, 2016
Genetic make-up strongly influences the skeleton's susceptibility to the loss of weight bearing with some inbred mouse strains experiencing great amounts of bone loss while others lose bone at much smaller rates. At young adulthood, female inbred C3H/HeJ
Bing Li, Jeyantt Srinivas Sankaran, Stefan Judex   +2 more
doaj   +1 more source