Results 21 to 30 of about 54,165 (230)

Insights Into Complex Murine Models of Allergy and Anaphylaxis: The Central Role of IgE and Mast Cells in Advancing Human Therapies. [PDF]

Eur J Immunol
Murine allergy model outcomes differ by sensitization route, allergen type, and mouse strain, influencing mechanisms such as IgE and mast cell involvement and the therapeutic relevance of each model. Understanding how experimental parameters shape outcomes is essential for selecting appropriate models and effectively translating findings to clinical ...
Nagata Y, Suzuki R.
europepmc   +2 more sources

The Establishment of the C3H Inbred Strain of Mice for the Study of Spontaneous Carcinoma of the Mammary Gland [PDF]

CA: A Cancer Journal for Clinicians, 1935
become interested in the use of inbred strains of mice for the study of sponta neous neoplasia. This advance has been encouraging to geneticists, who have in sisted, with great reason, that intrinsic or genetic factors do play a very important role in ...
L. Strong
openaire   +4 more sources

Fecal IgA, Antigen Absorption, and Gut Microbiome Composition Are Associated With Food Antigen Sensitization in Genetically Susceptible Mice

Frontiers in Immunology, 2021
Food allergy is a potentially fatal disease affecting 8% of children and has become increasingly common in the past two decades. Despite the prevalence and severe nature of the disease, the mechanisms underlying sensitization remain to be further ...
Johanna M. Smeekens, Johanna M. Smeekens, Brandi T. Johnson-Weaver, Andrew L. Hinton, Andrew L. Hinton, M. Andrea Azcarate-Peril, M. Andrea Azcarate-Peril, Timothy P. Moran, Robert M. Immormino, Janelle R. Kesselring, Janelle R. Kesselring, Erin C. Steinbach, Kelly A. Orgel, Kelly A. Orgel, Herman F. Staats, Herman F. Staats, Herman F. Staats, A. Wesley Burks, A. Wesley Burks, Peter J. Mucha, Peter J. Mucha, Martin T. Ferris, Michael D. Kulis, Michael D. Kulis   +23 more
doaj   +1 more source

Lack of Association between the Tlr4 (Lps^d/Lps^d) Genotype and Increased Susceptibility to Escherichia coli Bladder Infections in Female C3H/HeJ Mice

mBio, 2011
Toll-like receptor 4 is thought to have a primary role in host defense against Escherichia coli bladder colonization, based on mouse models of urinary tract infection using C3H/HeJ female mice. This strain carries a point mutation in the Tlr4 gene, which
Kaleigh A. Suhs, Brodie R. Marthaler, Rodney A. Welch, Walter J. Hopkins   +3 more
doaj   +1 more source

Large-scale albuminuria screen for nephropathy models in chemically induced mouse mutants [PDF]

, 2005
Background/Aim: Phenotype-driven screening of a great pool of randomly mutant mice and subsequent selection of animals showing symptoms equivalent to human kidney diseases may result in the generation of novel suitable models for the study of the ...
Aigner, B., de Angelis, M. H., Klempt, M., Rathkolb, B., Tran, T. V., Wanke, R., Wolf, E.   +6 more
core   +1 more source

Analysis of the sex-specific variability of blood parameters in C3H inbred mice by using data from a long-term, high-throughput project [PDF]

Physiological Research, 2021
Mice are important models for biomedical research by providing the possibility of standardizing genetic background and environmental conditions, which both affect phenotypic variability. Use of both sexes in experiments is strongly recommended because of possible differences in the outcome. However, sex-specific phenotypic variability is discussed with
Aigner, B., Rathkolb, B., Hrabě de Angelis, M., Wolf, E.   +3 more
openaire   +3 more sources

Polyoma virus-induced osteosarcomas in inbred strains of mice: host determinants of metastasis. [PDF]

PLoS Pathogens, 2010
The mouse polyoma virus induces a broad array of solid tumors in mice of many inbred strains. In most strains tumors grow rapidly but fail to metastasize.
Palanivel Velupillai, Chang Kyoo Sung, Yu Tian, Jean Dahl, John Carroll, Roderick Bronson, Thomas Benjamin   +6 more
doaj   +1 more source

A Neuroprotective Locus Modulates Ischemic Stroke Infarction Independent of Collateral Vessel Anatomy

Frontiers in Neuroscience, 2021
Although studies with inbred strains of mice have shown that infarct size is largely determined by the extent of collateral vessel connections between arteries in the brain that enable reperfusion of the ischemic territory, we have identified strain ...
Han Kyu Lee, Sarah E. Wetzel-Strong, David L. Aylor, Douglas A. Marchuk   +3 more
doaj   +1 more source

Cerebellar output controls generalized spike-and-wave discharge occurence [PDF]

, 2015
© 2015 The Authors Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (CC BY-NC-ND 4.0)
Alva, Parimala, Davey, N., De Zeeuw, Chris I., Eelkman Rooda, Oscar, Hoebeek, Freek E., Karapatis, Athanasios, Kros, Lieke, Negrello, Mario, Serdijn, Wouter, Spanke, Jochen, Steuber, Volker, Strydis, Christos, Tolner, Else, van den Maagdenberg, Arn, van Dongen, Marijn, Winkelman, Beerend   +15 more
core   +5 more sources

ForestPMPlot: A Flexible Tool for Visualizing Heterogeneity Between Studies in Meta-analysis. [PDF]

, 2016
Meta-analysis has become a popular tool for genetic association studies to combine different genetic studies. A key challenge in meta-analysis is heterogeneity, or the differences in effect sizes between studies.
Eskin, Eleazar, Han, Buhm, Kang, Eun Yong, Li, Xiao, Park, Yurang, Segrè, Ayellet V   +5 more
core   +3 more sources