Results 51 to 60 of about 54,165 (230)

Pdxdc1 modulates prepulse inhibition of acoustic startle in the mouse. [PDF]

, 2017
Current antipsychotic medications used to treat schizophrenia all target the dopamine D2 receptor. Although these drugs have serious side effects and limited efficacy, no novel molecular targets for schizophrenia treatment have been successfully ...
Boutros, PC, Feldcamp, LA, Fletcher, PJ, Nobrega, JN, Raymond, R, Wong, AHC   +5 more
core   +1 more source

In vivo microscopic voxel-based morphometry with a brain template to characterize strain-specific structures in the mouse brain

Scientific Reports, 2017
Hundreds of inbred mouse strains are established for use in a broad spectrum of basic research fields, including genetics, neuroscience, immunology, and cancer.
Keigo Hikishima, Yuji Komaki, Fumiko Seki, Yasuyuki Ohnishi, Hirotaka J. Okano, Hideyuki Okano   +5 more
doaj   +1 more source

Increased Variation in Body Weight and Food Intake Is Related to Increased Dietary Fat but Not Increased Carbohydrate or Protein in Mice

Frontiers in Nutrition, 2022
A variety of inbred mouse strains have been used for research in metabolic disorders. Despite being inbred, they display large inter-individual variability for many traits like food intake and body weight.
Yingga Wu, Yingga Wu, Yingga Wu, Sumei Hu, Sumei Hu, Dengbao Yang, Li Li, Li Li, Baoguo Li, Baoguo Li, Lu Wang, Lu Wang, Lu Wang, Min Li, Min Li, Min Li, Min Li, Guanlin Wang, Guanlin Wang, Guanlin Wang, Jianbo Li, Yanchao Xu, Xueying Zhang, Xueying Zhang, Xueying Zhang, Xueying Zhang, Chaoqun Niu, Chaoqun Niu, John R. Speakman, John R. Speakman, John R. Speakman, John R. Speakman   +31 more
doaj   +1 more source

Toll-like receptor expression in C3H/HeN and C3H/HeJ mice during Salmonella enterica serovar Typhimurium infection [PDF]

, 2003
Here, we have investigated the mRNA expression of Toll-like receptor 2 (TLR-2), TLR-4, and MD-2 in spleens and livers of C3H/HeN mice (carrying wild-type TLR-4) and C3H/HeJ mice (carrying mutated TLR-4) in response to Salmonella infection.
Bryant, Clare E, Foster, Neil, Kaiser, Pete, Maskell, Duncan J, Tötemeyer, Sabine   +4 more
core   +2 more sources

A dominant X-linked QTL regulating pubertal timing in mice found by whole genome scanning and modified interval-specific congenic strain analysis. [PDF]

PLoS ONE, 2008
BackgroundPubertal timing in mammals is triggered by reactivation of the hypothalamic-pituitary-gonadal (HPG) axis and modulated by both genetic and environmental factors. Strain-dependent differences in vaginal opening among inbred mouse strains suggest
Wangsheng Zhu, Zhongpeng Fan, Chao Zhang, Zhengxia Guo, Ying Zhao, Yuxun Zhou, Kai Li, Zhenghong Xing, Guoqiang Chen, Yinming Liang, Li Jin, Junhua Xiao   +11 more
doaj   +1 more source

Marked mitigation of transplant vascular sclerosis in FasL(gld) (CD95L) mutant recipients. I. The role of alloantibodies in the development of chronic rejection [PDF]

, 1999
Background. In the acute rejection of allografts, the interaction between Fas (CD95) and its ligand (FasL; CD95L) has been shown to be involved in mediating apoptotic cell death.
Aitouche, A, Fung, JJ, Rao, AS, Salam, A, Starzl, TE, Subbotin, V, Sun, H, Valdivia, LA   +7 more
core   +1 more source

Toll-like receptor 4 mutant and null mice retain morphine-induced tolerance, hyperalgesia, and physical dependence. [PDF]

PLoS ONE, 2014
The innate immune system modulates opioid-induced effects within the central nervous system and one target that has received considerable attention is the toll-like receptor 4 (TLR4).
Theresa Alexandra Mattioli, Heather Leduc-Pessah, Graham Skelhorne-Gross, Chris J B Nicol, Brian Milne, Tuan Trang, Catherine M Cahill   +6 more
doaj   +1 more source

A Comprehensive Genetic Analysis of Candidate Genes Regulating Response to Trypanosoma congolense Infection in Mice [PDF]

, 2010
Background: African trypanosomes are protozoan parasites that cause "sleeping sickness" in humans and a similar disease in livestock. Trypanosomes also infect laboratory mice and three major quantitative trait loci (QTL) that regulate survival time after
Amwayi, Peris, Archibald, Alan, Brass, Andy, Gibson, John, Goodhead, Ian, Hall, Neil, Hughes, H., Iraqi, Fuad, Kemp, Stephen J., Limo, Moses, Margaret, A., Noyes, Harry A.   +11 more
core   +4 more sources

Mitochondrial haplotype and sex modulate responses to endurance exercise training

The Journal of Physiology, EarlyView.
Abstract figure legend Using OKC‐HETB/W rats we demonstrate that mitochondrial haplotype influences training responses of endurance exercise. Overall OKC‐HETW rats showed greater responses than OKC‐HETB in exercise tolerance, mitochondrial bioenergetics, mitochondrial DNA (mtDNA) mutation frequencies and motor co‐ordination.
Bumsoo Ahn, Tianhao Wei, Ryan Pettit‐Mee, Eunyoung Kim, Robert V. Musci, Jonathan Wanagat, Hoang Van M. Nguyen, Arlan Richardson, Hyunyoung Kim   +8 more
wiley   +1 more source

Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel candidate genes for pulmonary function

Respiratory Research, 2017
Background Failure to attain peak lung function by early adulthood is a risk factor for chronic lung diseases. Previously, we reported that C3H/HeJ mice have about twice total lung capacity (TLC) compared to JF1/MsJ mice.
Leema George, Ankita Mitra, Tania A. Thimraj, Martin Irmler, Sangeetha Vishweswaraiah, Lars Lunding, Dorothea Hühn, Alicia Madurga, Johannes Beckers, Heinz Fehrenbach, Swapna Upadhyay, Holger Schulz, George D. Leikauf, Koustav Ganguly   +13 more
doaj   +1 more source