Results 81 to 90 of about 54,165 (230)

Genetic factors regulating lung vasculature and immune cell functions associate with resistance to pneumococcal infection [PDF]

, 2004
Streptococcus pneumoniae is an important human pathogen responsible for high mortality and morbidity worldwide. The susceptibility to pneumococcal infections is controlled by as yet unknown genetic factors.
Jonczyk, Magda S., Simon, Michelle, Kumar, Saumya, Fernandes, Vitor E., Sylvius, Nicolas, Mallon, Ann-Marie, Denny, Paul, Andrew, Peter W.   +7 more
core   +5 more sources

Susceptibility of inbred mice to Leishmania major infection: genetic analysis of macrophage activation and innate resistance to disease in individual progeny of P/J (susceptible) and C3H/HeN (resistant) mice [PDF]

Infection and Immunity, 1990
We tested the possibility that two phenotypic traits, defective activation of macrophage antileishmanial activities and susceptibility to infection with Leishmania major, were controlled by the same gene. We used P/J (susceptible) and C3H/HeN (resistant) mice to breed F1, backcross (Bx), and F2 mice that were tested individually for both traits, each ...
A H, Fortier, A, Tong, C A, Nacy
openaire   +2 more sources

Differential miRNA expression in inherently high- and low-active inbred mice

Physiological Reports, 2015
Despite established health benefits of regular exercise, the majority of Americans do not meet the recommended levels of physical activity. While it is known that voluntary activity levels are largely heritable, the genetic mechanisms that regulate ...
Michelle Dawes, K. Kochan, P. Riggs, J. Timothy Lightfoot   +3 more
semanticscholar   +1 more source

Transcriptomic Signature of Frailty in Older Patients With Cardiovascular Disease Undergoing Cardiac Surgery or TAVI

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 3, June 2025.
ABSTRACT Background Deterioration of functional capacity mostly determinates frailty in older patients with cardiovascular disease (CVD). Elucidating the pathophysiological mechanisms of physical frailty is an important goal for improving functional health‐related outcomes. Our objective was the determination of the transcriptomic signature of physical
Omar Baritello, Simon H. Sündermann, Kristian Espinosa‐Garnica, Jörg Kempfert, Markus Jähnert, Nick L. Beetz, Dominik Geisel, Jasmin Gaugel, Julia Rominger, Ursula Müller‐Werdan, Catrin Herpich, Kristina Norman, Alexandra Chadt, Hadi Al‐Hasani, Heinz Völler, Annett Salzwedel, Heike Vogel   +16 more
wiley   +1 more source

Strongyloides venezuelensis infection susceptibility of seven inbred strains of mice Susceptibilidade de sete linhagens isogênicas de camundongos à infecções por Strongyloides venezuelensis

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2002
A trial was carried out to investigate the susceptibility of seven strains of mice to Strongyloides venezuelensis primary and secondary experimental infections, in order to provide the basis for genetic studies about resistance.
A.F.T. Amarante, T.C.G. Oliveira-Sequeira   +1 more
doaj   +1 more source

Vaccines against toxoplasma gondii : challenges and opportunities [PDF]

, 2009
Development of vaccines against Toxoplasma gondii infection in humans is of high priority, given the high burden of disease in some areas of the world like South America, and the lack of effective drugs with few adverse effects.
Aliberti J, Angus CW, Aosai F, Aosai F, Awan KJ, Beghetto E, Bommireddy R, Bonenfant C, Boyle JP, Brinkmann V, Buxton D, Bülow R, Caetano BC, Conacher M, Cong H, Cong H, Constant SL, Couper KN, Craig W Roberts, Cui YL, Cuppari AF, Curtsinger JM, Curtsinger JM, Cutchins EC, Darcy F, Dautu G, Debard N, Debierre-Grockiego F, DeGregorio E, Denkers EY, Desolme B, Duquesne V, Echeverria PC, Elisabeth Förster-Waldl, Erik Jongert, Escajadillo A, Eskild Petersen, Fachado A, Fachado A, Flori P, Fox B, Frenkel JK, Garcia JL, Garcia JL, Gatkowska J, Gazzinelli R, Gazzinelli RT, Golkar M, Hakim FT, Igarashi M, Innes EA, Ishii K, Ishii KJ, Ismael AB, Ismael AB, Johnson LL, Jongert E, Jongert E, Jongert E, Kasper LH, Khan IA, Kijlstra A, Kodjikian L, Krahenbuhl JL, Kringel H, Letscher-Bru V, Letscher-Bru V, Leyva R, Lindsay DS, Liu Q, Lourenco EV, Lourenço EV, Martin V, McLeod R, Mishima M, Mishima M, Mohamed RM, Mévélec MN, Mévélec MN, Nicola Gargano, Nielsen HV, Nielsen HV, Petersen E, Petrovsky N, Pettersen EK, Pfefferkorn ER, Qu D, Reikvam A, Roque-Resendiz JL, Sabin AB, Sayles PC, Schaap D, Scorza T, Siachoque H, Sibley LD, Silveira C, Stanley AC, Stockinger B, Supply P, Taneja V, Vandepapelierea P, Velge-Roussel F, Velge-Roussel F, Vercammen M, Vogel N, Vyas JM, Waldeland H, Wang H, Wilkins MF, Williams MA, Xue M, Xue M, Yang CD, Yarovinsky F, Zenner L, Zhang G, Zhang J, Zimmermann S   +117 more
core   +3 more sources

TcMAC21 mouse model recapitulates abnormal vascular physiology observed in humans with Down syndrome

Physiological Reports, Volume 13, Issue 11, June 2025.
Abstract People with Down syndrome (DS) have abnormal vascular physiology, demonstrated by low systolic blood pressure (BP) and low aortic stiffness that are accompanied by endothelial dysfunction. The TcMAC21 mouse model of DS has many features observed in people with DS, although vascular physiology has not been studied.
Xiangyu Zheng, Mostafa Sabouri, Bryan J. Irwin, Joseph Bernardo, Daniel R. Machin   +4 more
wiley   +1 more source

Standardized, systemic phenotypic analysis of Umod(C93F) and Umod(A227T) mutant mice. [PDF]

PLoS ONE, 2013
Uromodulin-associated kidney disease (UAKD) summarizes different clinical features of an autosomal dominant heritable disease syndrome in humans with a proven uromodulin (UMOD) mutation involved.
Elisabeth Kemter, Petra Prückl, Birgit Rathkolb, Kateryna Micklich, Thure Adler, Lore Becker, Johannes Beckers, Dirk H Busch, Alexander A Götz, Wolfgang Hans, Marion Horsch, Boris Ivandic, Martin Klingenspor, Thomas Klopstock, Jan Rozman, Anja Schrewe, Holger Schulz, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabé de Angelis, Eckhard Wolf, Bernhard Aigner   +21 more
doaj   +1 more source

High-Density Genotypes of Inbred Mouse Strains: Improved Power and Precision of Association Mapping. [PDF]

, 2015
Human genome-wide association studies have identified thousands of loci associated with disease phenotypes. Genome-wide association studies also have become feasible using rodent models and these have some important advantages over human studies ...
Churchill, Gary A, Eskin, Eleazar, Lusis, Aldons J, Parks, Brian, Rau, Christoph D, Simecek, Petr, Wang, Yibin   +6 more
core   +1 more source

The impact of cysteine on lifespan in three model organisms: A systematic review and meta‐analysis

Aging Cell, Volume 24, Issue 2, February 2025.
We conducted a meta‐analysis to investigate the impact of cysteine supplementation on lifespan in mice, nematodes, and fruit flies. Positive effects were observed in C. elegans, transgenic flies, and disease model mice, but not in wild‐type flies and wild‐type mice.
Yue Ma, Mengqi Chen, Kaiyao Huang, Wakam Chang   +3 more
wiley   +1 more source